Background and Aim: Breast cancer is the most common cancer among women which leaves a profound impact on their psychosocial health and pain experience. The aim of this study was to determine the effect of group psychotherapy based on Acceptance and Commitment Therapy (ACT) on pain-related anxiety and cognitive emotion regulation of women with breast cancer. 
Methods & Materials: In this quasi-experimental study, subjects were 68 women with breast cancer refereed to Shahid Ghazi Hospitalin Tabriz, Iran who were selected using a convenience sampling method. Then, they were randomly assigned into two groups of intervention (n = 34) and control (n = 34). The intervention group underwent eight 90-min sessions of ACT-based group therapy, while the control group received no any intervention. They completed Pain Anxiety Symptom Scale Short Form and Cognitive Emotion Regulation Questionnaire before and one week after treatment. Collected ata were analyzed by using t test, chi-square test, ANCOA and MANCOVA. 
Ethical Considerations This study has obtained its ethical approval from the Research Ethics Committee of Tabriz University of Medical Sciences (code: IR.TBZMED.REC.1397.287) and has been registered by Iranian Registry of Clinical Trials (code: IRCT2017100615590N5).
Results: The ACT-based intervention improved the dimensions of pain-related anxiety (8.44±1.5) and cognitive regulation of negative (8.40±3.5) and positive (8.39±7.5) affects (P<0.001).
Conclusion: ACT-based intervention can help breast cancer patients to accept their negative thoughts and current conditions. 

Background and Aim: Diabetes is one of the most common chronic diseases in children and adolescents. Due to its specific problems, it can sometimes lead to substance abuse in adolescents through reduced health and increased depression and stress. The present study aimed to investigate the relationship of substance abuse with depression and stress in diabetic adolescents mediated by conflict resolution and problem solving skills.
Methods & Materials: This is a descriptive/correlational study. The study population consisted of all diabetic adolescent members of Urmia Diabetes Association and those referred to Imam Khomeini Hospital and diabetes specialists in Urmia city in Spring 2019. Of these, 206 were selected using a purposive sampling method. data collection tools were Substance Abuse Subtle Screening Inventory - Adolescents Version (Miller & Lazowski, 2001), Beck’s Depression Inventory (Beck et al, 1988), The Perceived Stress Scale (Cohen et al, 1983), Problem Solving Inventory (Heppner & Petersen, 1982) and Conflict Resolution Style Inventory (Weeks, 1994). Collected data were analyzed by using Pearson correlation test and structural equation modeling in SPSS and LISREL applications.
Ethical Considerations All ethical principles were considered in this study,.
Results: Depression and stress directly had a negative and significant effect on conflict resolution and problem solving skills, but had no significant effect on substance abuse. Conflict resolution and problem solving skills directly had a negative and significant effect on substance abuse. Moreover, depression and stress indirectly had a significant effect on substance abuse through medication by conflict resolution and problem solving skills (P<0.05).
Conclusion: Depression and stress can lead to increased substance abuse in diabetic adolescents by decreasing conflict resolution and problem solving skills. Therefore, in order to reduce substance abuse in these patients, it is recommended to hold training workshops to reduce their depression and stress and improve conflict resolution and problem solving skills.

Introduction: Sleep quality is one of the effective variables in other psychological characteristics, especially in multiple sclerosis patients. As a result, the present study was conducted with the aim of determine the role of interpersonal problems and illness perception in predicting sleep quality with mediating distress tolerance in multiple sclerosis patients.
Methods: This was a cross-sectional correlational study. The research population was all patients who were members of the Multiple Sclerosis Association of Urmia township in the first quarter of 2021 year. The sample size was estimated 315 people who were selected by available sampling method. The research data were collected by Barkham et all short version of interpersonal problems inventory (1996), Broadbent et all brief illness perception questionnaire (2006), Buysse et all Pittsburgh sleep quality index (1989) and Simons & Gaher distress tolerance scale (2005) and were analyzed by Pearson correlation coefficients and path analysis methods in SPSS-19 and PLS-3 software. This research with the IR.IAU.URMIA.REC.1400.022 ethics code is approved by the ethics committee in biomedical research of Islamic Azad University of Urmia branch.
Results: The results showed that the increase of interpersonal problems and negative perception of illness led to decrease the distress tolerance and loss of sleep quality and an increase of distress tolerance improved sleep quality. In addition, the decrease of interpersonal problems and negative perception of illness with mediating distress tolerance led to improved sleep quality (P<0.01).
Conclusions: According to the results, to improve the sleep quality of multiple sclerosis patients can be increased the rate of their interpersonal problems and illness perception and decreased their distress tolerance.