Showing 4 results for Zargar
Dr Mohammad Ali Zargar Shooshtari, Dr Abolfazl Golmohammadi, Dr Meysam Jamshidi, Dr Hormoz Salimi,
Volume 9, Issue 1 (3-2006)
Abstract
Introduction: Renal cell carcinoma can be presented with extension of thrombosis to renal vein and inferior vena cava. Management of these patients consists of radical nephrectomy and thrombectomy. In this study we reviewed approach to these patients. Materials & Methods: This is a case series report. During 1379 to 1384, 148 patients diagnosed with renal cell carcinoma (RCC) limited to Gerota’s fascia (stage T3 or less) were admitted to Hasheminejad hospital. Fourteen patients had inferior vena cava (IVC) involvement. Radical nephrectomy as well as thrombectomy was performed in 8 patients. This investigation is done on these 8 patients. Results: Patients' average age was 51.4 years. Six patients were male (75%) and 2 female (25%). The most common symptoms were flank pain (75%), gross hematuria (62.5%) and structural symptoms (50%). All patients had tumors limited to Gerota’s fascia without any distant metastasis. Infrahepatic involvement of IVC was seen in 6 patients and in 2 patients thrombosis extended above the hepatic vein (infrahepatic). No perioperative mortality was seen. Postoperative complications were atelectasia in 2 patients and deep vein thrombosis in one which was treated with conservative management. Conclusion:By skillful surgical approach in patients with RCC and IVC involvement, thrombosis can be completely excised without increasing the rate of complications and longterm survival could be expected.
Parsa Zargar, Esmaeel Ghani, Farideh Jalali Mashayekhi, Ebrahim Eftekhar,
Volume 19, Issue 3 (6-2016)
Abstract
Background: A small percent of patients with colorectal cancer (CRC) respond to 5-Fluorouracil (5-FU), as a first line of chemotherapy. In this study in, in order to design a new chemotherapy protocol, the effect of 5-FU and acriflavine (ACF) cotreatment on mortality rate of CRC cell lines was investigated.
Materials and Methods: Cytotoxicity of 5-FU and ACF against CRC cell lines (LS174T, SW480 and HCT116) was detected using MTT assay. Cells were treated with different concentrations of 5-FU (0.5-64 µM) or ACF (0.07-5 µM) for 72 hours and then cell viability and drugs IC50 was calculated. To assess the effect of ACF on anticancer activity of 5-FU, cells were cotreated with different concentrations of 5-FU and IC30 concentration of ACF.
Results: ACF and 5-FU suppress the viability of CRC cell lines in dose-dependent manner. 5-FU and ACF have most cytotoxic effect on LS174T and the lowest cytotoxic effect on SW480 cells. Cotreatment of ACF with 5-FU could not significantly change the sensitivity of cells against 5-FU (p>0.05).
Conclusion: In this study, the fatal and cytotoxic effect of ACF on three CRC cell lines was shown. However, cotreatment of ACF with 5-FU could not improve the anticancer activity of 5-FU.
Ailar Sabbaghi, Mohsen Zargar, Amir Ghaemi, Farahnaz Motamedi-Sedeh, Mohammad Reza Zolfaghari,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim We need the next-generation of whole-inactivated influenza vaccines to create stronger cross-protection against different influenza subtypes. This research aimed to apply the inactivation process of the influenza virus through gamma radiation as a candidate for the development of whole-inactivated vaccines.
Methods and Materials The influenza virus strain A/PR/8/34 (A/Puerto Rico/8/34 [H1N1]) was propagated in Madin-Darby Canine Kidney (MDCK) epithelial cells. After ultrafiltration, the virus infectivity titer was calculated by 50% Tissue Culture Infectious Dose (TCID 50%) method based on the Karber formula. Alternatively, the gamma cell-220 was applied for virus inactivation via gamma rays. The D10 value factor and optimum dose of virus inactivation were calculated based on the dose/survival curve and the initial viral titer. In addition, antigenic properties of irradiated viruses compared to un-irradiated viruses and complete inactivation of the irradiated samples with optimum dose were also evaluated by hemagglutination assay and safety test, respectively.
Ethical Considerations The Research Ethics Committee of Islamic Azad University, Tehran Medical Branch, Iran approved this study (Code: IR.IAU.TMU.REC.1397.309).
Results According to the concentrated virus titer (TCID50: 105.75/ml) and dose/survival curve, the D10 value factor and optimum dose of virus inactivation were calculated at 4.878 and 28.048 kGy, respectively. On the other hand, owing to the results obtained from the safety test and hemagglutination assay, the optimum dose of virus inactivation was determined to be 28 kGy by maintaining the antigenic properties.
Conclusion Gamma radiation appears to be a good candidate for vaccine development through maintaining the antigenic structures.
Phd Zahra Akhavisamarein, Mis Shirin Ahmadi, Mis Rana Pourzargar,
Volume 26, Issue 1 (April & May 2023)
Abstract
Introduction: Considering the destructive effects of the prevalence of infectious diseases such as Covid-19 and the resulting social crisis on physical and mental health, a leading study was conducted to investigate Pattern of structural relationships of Covid-19 epidemic anxiety based on self-control mediated by emotional resilience.
Methods: The method of this research was descriptive-correlational and the statistical population of the present study included all students of Mohaghegh University in the academic year 2021-2022. Corona, resilience, completed the self-control questionnaire. Pearson correlation coefficient tests and structural equation modeling using Spss.25 and Lisrel 8.8 software were used to analyze the data.
Ethic: This research has been approved by the ethics code IR.ARUMS.REC.1400.045 in the ethics committee of Ardabil University of Medical Sciences.
Results: The results showed that coronary anxiety was negatively associated with self-control and emotional resilience. Emotional resilience is also positively associated with self-control. Model fit indices also confirmed the path of self-control over coronary anxiety mediated by emotional resilience.
Conclusions: According to the results of the current study, psychiatric clinics, counseling centers and health networks can use the findings of the research in the field of mental health and to face the covid-19 epidemic.
