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Introduction: Alimentary  parasitic  infections  are  still  one  of  the  main  problem  in  developing  countries, and  their  relation  with  environmental  factors  are  important.  Since  children  are  more  vulnerable  to  these  infections, in  basic  researchers  this  group  is  more  targeted.
Materials  and  Methods:  This  descriptive-analytical  cross-sectional  study  was  carried  out  on  1-13  years  children  who  were  living  in  Shahrak-e-Valiasr  Arak.  Simple  random  sampling  was  used  for  selecting  385  children.  Three  days  collected  feces  samples  from  each  person  were  examined  using  formaline-ether  concentration  technique. Data  were  analyzed  by  Chi  square  method.
Results:  The  results  showed  a  prevalence  of  42.3%  of  intestinal  parasitic  infections  in the  children. From  these, 17.4%  were  pathogen  parasits. The  highest  prevalence  was  reported  for  Giardia  lambia  (16.6%).  Girls  were  more  infected  than  boys.  The  level  of  infection  was  significantly  increased  by  age. The  prevalence  of  the  infection  was  more  in  orphans  or  in  children  who  had  uneducated  parents.
Conclusion:  Since  date  indicated  of  a  high  prevalence  of  intestinal  parasitic  infections  in  the  children. It  is  suggested  to  use  washed  and  clean  vagetables   and  fruits  and  also  emphasize  on  personal  and  environmental  hygiene.

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Introduction: Saffron (crocus sativus L.), an important spice rich in carotenoids, is used in folk medicine to treat numerous diseases. This study examines the effects of saffron consumption on innate and humoral immunity of healthy male students.
Materials and Methods: 41 healthy volunteered university students in two control and case groups were included in this study and consumed respectively milk and milk containing saffron for 6 weeks. Blood samples were collected from the subjects at weeks 0, 3 and 6. Innate immunity was evaluated by determining the percentage and counts of monocytes, neutrophils, eosinophils, basophils, platelets and the total white cells, CRP concentration and C3 and C4 concentrations and humoral immunity was assessed by deterning the percentage of lymphocytes and the concentrations of IgG, IgM and IgA.
Results: Three weeks after saffron consumption, monocytes percentage and IgG concentration increased significantly (P<0.05, P=0.01). Total white blood cells and platelets count also reduced significantly (P<0.05). After 6 weeks, monocytes percentage and IgG concentration reduced significantly (P<0.05, P< 0.001) and platelets count increased significantly (P<0.05) as compared with week 3.
Conclusion: This investigation demonstrated that saffron consumption enhances innate and humoral immunity systems and has anti-inflammatory effects. These effects depending on the duration of saffron consumption.

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Introduction: The protein-energy malnutrition is the most prevalent cause of malnutrition and always occures in infants and children under 5 years old. According to the harmful effects of malnutrition, such as high mortality, inability of learning and decrease of mental and physical ability, reconnoite and study of malnutrition qualification is very important.
Material and Methods: This analytic cross-sectional study was carried out on 811 children under 5 years old who were living in rural zone of Arak. Based on health files, clinical inspections and interview with mothers a checklist was fulfilled for every child. Data were analysed by EPI6 software
Results: In this study, none of the children had stricken with Kwashiorkor or Marasmic-Kwashiorkor. Undernourished were seen in 7.39% and Marasmus were also seen in 1.1% of subjects. The prevalence of malnutrition was 7.5% in Wellcome, 33.55% in Waterlow-Stunting, 23.05% in Waterlow-Wasting and 30.94% in Gomez classification. There was statistically correlation between malnutrition and respiratory infection rate, milstones, birthweight, maturity and begning of helpfood (P<0.05).
Conclusion: Considering the results, the most rate of malnutrition in each classification was mild. It is suggested that increasing of familial awareness is an important factor for preventing from next damages and additional treatment costs.

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Introduction: Previous studies indicated that children, who acquired conversation concept, produce adjectives better than other mental retarded.
Other studies showed that Down syndrome children have lower linguistic abilities than other mental retarded children. The main goal of this research was to study the effects of Down syndrome on production of semantic skills.
Materials and' Methods: This analytic cross-sectional study was conducted on girls who studied in exceptional primary schools of Semnan city.
Samples were chosen systenlaticaly. At first, 38 Down syndrome girls, who were monolingual and with no sign of sensory and motor deficits, were selected.
Then, 37 mental retarded girls (non-Down syndrome), that mental retardation had no specific ethiology, were matched on date of birth, educational level, failuer in previous classes, parent's job and education. These 75 pupils participated in operative tests and those who were able to comprehend the concept of conversation were examined by Raven Colourd Progressive Matrices. At final stage, 30 educable girls were participated in production test.
Results: Our findings showed that:
1. The production of nominal and superlative adjectives were equivalent between two groups, but Down syndromes had lower ability in production of comparatives;
2. The simplisity of adjectives were as fallow: nominal> comparative> superlative, and big-small> tall-short> thick-thief> wide-narrow.
3. There were few samples able to produce superlatives.
Conclusion: This investigation revealed that girls suffering from Down syndrome have lower ability on production of semantic skills.

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Introduction: Hidden hepatitis B is a condition in which the surface antigen of hepatitis B in the patient's serum is negative but the DNA of the hepatitis B virus is detected in the serum or liver tissue. In this study, the prevalence of latent hepatitis B in chronic hepatitis C patients and their biochemical and histological changes were investigated.
method: In this descriptive study, target sampling was performed so that 27 chronic hepatitis C patients whose HBsAg was negative and during 2001 and 2002 to two hepatitis centers of Tehran and Research Center for Gastrointestinal and Liver Diseases of Shahid University of Medical Sciences Beheshti came in and underwent liver sampling. On the hepatic paraffinic block of these patients, polymerase chain reaction tests were performed for the presence of HBVDNA, as well as immunohistochemical tests for the presence and detection of HBsAg and central hepatitis B antigen.
Results: Of the 27 PCR samples examined, patients reported positive HBVDNA in 5 cases (19%). In all of these patients, IHC tests were reported to be negative for HBsAg and HBcAg. Histological changes of cirrhosis and irreversible cirrhosis symptoms were seen only in the HBVDNA group.
Conclusion: The prevalence of latent hepatitis B is relatively high in patients with hepatitis C. In these patients, latent hepatitis B can exacerbate liver damage and accelerate the progression of cirrhosis.

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Introduction: Sexual instinct which is the cause of numerous changes in one’s life could be influenced by numerous factors such as menopause and aging. This study was focused on comparison of women’s sexual functioning disorders before and after menopause. Materials and Methods: This is an analytic cross sectional study in which data related to before and after menopause sexual activities of 174 married women (living with their spouses), referring to health centers in Isfahan in 2003 was collected and investigated. Data was collected by a self constructed sexual dysfunction inventory in which reliability and validity were reached by content validity and α chorenbach index. Findings were analysed through descriptive and inferential (MC-Nemar) statistics. Results: Findings showed that relative frequency of sexual functioning disorders in productive period was 38% and in menopausal period 72.4%. There was a significant association between sexual functioning disorders before and after menopausal period (P < 0.001). Frequency distribution of sexual functioning disorders in productive period of these women according to severity of disorders were: sexual desire disorder (49/2%), dyspareunia (34/3%), arousal dysfunction (26/8%), orgasmic dysfunction (23/8%), and vaginismus (16/4%). Frequency distribution of sexual functioning disorders in menopausal period of these women were: arousal dysfunction(75/3%), sexual disire disorder (62/6%), orgasmic dysfunction (56/3%), dyspareunia (34/9%) and vaginismus (15/8%).
Conclusion: As revealed by the findings of the study,a high percentage of women experience sexual functioning disorders in productive and menopausal periods. Menopause can be a cause to occur, or continue these disorders. The role of health care professinals in conselling and education is emphasized.

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Introduction: Dysmenorrhea is one of the most prevalent complaints of women which is due to Prostaglandin release and is treated by chemical drugs. Today regarding side effects of these drugs, scientists are increasingly moving toward using herbal drugs. This study is planned to comparison the effects of Thymus Vulgaris and Mefenamic acid on primary dysmenorrhea.
Materials and Methods: This is a clinical trial study. Target population was women suffering from primary dysmenorrhea and study population was women reffering to marriage consulting center. Based on α=0/5, β=0/20, sample size was calculated 214 which were divided into two groups randomly. Samples were asked to determine their pain severity before using the drug, by a visual scale (0-10cm). In the study group each sample cosumed 15 grams Thyme leaf brewed in a glass of water and in control group samples used 250mg Mefenamic acid capsules. Then pain severity was determined again 1, 2 and 3 hours after using drugs. Data was analysed by mean and standard deviation indexes and K-S, man-whitney and chi-square tests. Helsinki declaration was regarded at all stages of the research.
Results: Pain severity mean, before using the two drugs had no significant difference between groups. In each group, pain severity was significantly decreased before and after using the drug (p=0.05). But the rate of decreasing pain between the two groups showed no significant difference.
Conclusion: Regarding results, it seems both Mefenamic acid and Thymus Vulgaris decrease pain at the same level which seems to be due to Thyme,s antiprostaglandin and antispasmodic effects.

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Introduction: Many research demonstrate the effect of margarine trans fatty acids on many physiological mechanisms in both human and animals. The purpose of this research was to evaluate the effects of margarine oil on reproduction in Wistar rat. Materials and Methods: ‏This is an experimental study in which 46 Wistar female and male rats were divided into 4 groups. Male and female rats in group 1 were fed by 3% Margarine oil and standard food, in group 2 only female rats and in group 3 only male rats had Margarine oil with the standard food. Male and female rats in group 4 (as control group) had only standard food. Administration was started one month pre mating and continued during mating, gestation and lactation periods. After delivery, the pups were assessed for overall number, sex ratio, body weight, and mortality. One way analysis of variance was used for data avalysis. Results: ‏Results showed that weight and female ratio of pups were significantly increased in group 2 as compared to group 1 and control. Also the comparison of pups’ mortality in the four groups showed that pups mortality was increased in group 2 as compared to the other groups. On the other hand there was no significant difference in number of pups in the four groups. Conclusion: The results showed that dietary Margarine oil administration to female rats can significantly increase weight, ratio of female pups and mortality of pups.

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Introduction: Prolonged labor is an important problem during labor which can have undesirable effects on both maternal and fetal health. Shortening the duration of labor has always been one of the aims of obstetricians. Hence, the purpose of this research was to investigate the effect of massage on the duration of labor in women attending to Bentolhoda Maternity Unit in the city of Bojnord, Northern Khorasan, Iran in 2005. Materials and Methods: In this clinical tial study, 62 primiparous women with normal pregnancy were participated. The indications of normal pregnancy included a gestational age of 37-42 weeks, single tone, and vertex presentation. Sampling was done by purposive method. Women were randomly allocated in two groups. The experimental group (n=32) received a 30-minute directional, reasonably firm and rhythmic effleurage massage in the back in each of the three phases of labor. The control group (n=30), did not receive any form of massage and received a routine 30-minutes nursing care in each of the three phases. Measurements were then made for strength, interval and frequency of contractions and the duration of each phase. Data were analyzed using student t, Chi-square and Mann-Whitney tests. Results: Findings showed a significant decrease in the duration of labor after massage sessions. The mean duration of labor for the massage group was 5.75 hourse and for the routine nursing care group 9.15 houres (p=0.001). Conclusion: According to the above results, there was a significant decrease in duration of the first phase of labor in pregnant women receiving massage sessions. Therefore, this method can be used to decrease the period of hospitalization.

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Introduction: Urinary tract infection is one of the most common nosocomial infections that mainly occur after instrumentation in urinary tract, particularly after urinary catheterization. This study was conducted to assess disinfection's effects of meatus and urinary catheter with 10% Povidone Iodine ointment on incidence of bacteriuria in hospitalized patients of neurological unit of Shohadaye Tajrish hospital in iran. Methods and Materials: This study , is a randomized clinical trail which is done on Seventy stroke's patients that were catheterized by urologic expert's selected on convenience sampling and randomly divided to tow groups (Experimental group: 35 patients, Control group: 35 patients). In the experimental group, meatus and catheter drainage tube junction were disinfected daily and spigot was disinfected tow times a day by PVP10% ointment. In the control group the cares were done by normal saline. In days: 2,5,8,11,14 a urine sample was sent to lab for culture. The maximum period of study was 14 days. Results: Incidence of bacteriuria in experimental and control groups were 20% and 42.9%, respectively. Relative risk was 2.14. In patients with positive urine cultures: puri was 85.7% in experimental group and 86.6% in control group. Clinical symptoms of UTI were seen in 28.6% in experimental group and 33.3% in control group. Conclusion: This study showed that application of povidone-iodine 10% ointment for disinfection meatus and catheter drainage tube junction is effective to prevent catheter-associated urinary tract infection in male patients.

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Introduction: Cataract is a type of tarnish observable opacity in different layers constituting the lens and will cause light occlusion or scattering. Necessity for treatment of Cataract via surgery and its close relation with corneal astigmatism, when we applied a new method in cutting and type of cataract surgery, led us to measure the post-operation corneal astigmatism changes in frown incision Phacosection. Materials and Methods: This interventional study has been done on 73 eyes(58 patients). These patients were gone under Cataract surgery via no stitch frown incision scleral tunnel phacosection method. In this study we have 7mm external scleral incision with no suture. They were Keratometerized in four separate periods including pre-operation, one week, one month and three months post- operation. Data was analyzed using independent and paired t-tests. Results: Age, sex and left or right eye had no influence on astigmatism. Mean pre- operation astigmatism was 0.84 ± 0.87D, mean astigmatism 1 week post- operation was 0.27 ± 0.88 D, 1 month post- operation 0.06 ± 0.82 D, and three months post-operation was -0.03 ± 0.85 D (P= 0.0001). Before operation, 80% of the patients did have an astigmatism rate less than 1D that increased to 94.5% in three months period after operation and in 89% of the cases, the ultimate change in astigmatism has been found lower than 1D. The obtained information revealed that there is a meaningful difference between pre-operation astigmatism and the same after one week, one month and three months post-operation(P= 0.0001). Independent sample t and paired t-test were used to analyse data. Conclusion: Our study indicated that the no stitch frown incision scleral tunnel phacosection surgery can reduce pre-op corneal astigmatism, and because of induction of the slight controlled astigmatism we can apply this technique for all cataractic patients

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Background: Pain is an unpleasant feeling which humans experience. It is a warning sign of the damaged tissue. Due to the awful sense of pain, scientists always attempt to relieve it. Retinoic acid (RT), an active metabolite of natural vitamin A has important roles in modulation of the inflammatory responses. The aim of the present study was to analyze the pain threshold of rats which had microinjections of RT, applying acute and chronic models. Methods and Materials: In this study, the tail flick and formalin tests were used to determine pain threshold. In each test, the acute and chronic pain thresholds of 252 Wistar male rats (275 ± 25 gr) were assayed. The druge were injected in the acute model one-dose30 minutes before behavioral testing and in chronic model two-dose for one or two-weeks. The rats of both models divided randomly into six groups (n=7). In four treatment groups retinoic acid (RT) intra cerebro ventricular (i.C.V) were injected as dosagc of 0.5, 3 and 6 (µg/kg) micrograms per kilogram. In control group, was microinjected by ACSF. In vehicle group injected RT solvent (DMSO+ Distil water). Results: The resuits Showed acute injection of RT did not change pain thresholds in the tail-flick methd, but the chronic administration of RT (0.5, 1, 3, 6 µg/kg) reduced tail-flick latencies of the rats (p<0.05) in compare to DMSO group. The threshold of pain in the first phase of formalin test was reduced after injection of 3µg/kg of RT for two weeks. Conclusion: It was concluded that chronic i.c.v. injections of RT can induce significant hyperalgesia in rat.

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Background: According to the report of Iranian Center of Disease Control, in the summer of 2005 an outbreak of cholera (Inaba serotype) occurred in Iran. The outbreak lasted the mid of September. The aim of this study was to use the result of different studies performed during this period to determine source of infection. Methods and Materials: This is a meta-analysis study, which studies performed in Qum, Arak, Karaj, Golestan and Ghazvin were eligible. All of these studies were case control ones performed during the August 2005. The total of cases were 531. Pooled odds ratios was used to estimate by fixed and random method. All computations were performed by Stata 8 software. Results: The estimated pooled odds ratios resulted from 5 differemt studies were used in the meta-analysis as the following: travelling (1.64 95% CI: 0.98-1.88), non-pasteurized ice cream (0.88 95%CI: 0.48-1.61), post toilet hand washing (3.72 95% CI: 0.86-16.05), eating meal outside home (2.38 95% CI: 1.46-3.90), raw fruit eating (0.98 95% CI: 0.42-2.18) and raw vegetables use (5.36 95%CI: 2.4-12). Conclusion: According to the results of this study raw vegetable use and having meal outside home were significantly associated to the cholera in mentioned provinc

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Background: Sensory signals and intrinsic activity of the neuronal circuits deeply influence on developing the sensory systems in early life. Light deprivation of animals is known as an established method in assessment of environmental signals in development of the nervous system. Methods and Materials: In this experimental study eighteen male rats at 75 days of postnatal age were used. The animals were divided in two groups, one reared in a cycle of 12light/12dark (light reared-LR) and the other keep in darkness since birth through experiment (Light deprived- LD). The animals were trained in a Morris water maze for spatial memory. They must navigate the maze until finding a platform hidden 1 cm below of water. Then, the time required and the distance spent to find the platform were measured for assessment of the animal behavior. Each animal was given 4 trials/day and the experiment lasted for 6 days. This stage was followed by probe and postprobe tests to evaluate how the learning is consolidated. Results: The results indicated that, compared to their LD counterparts, the LR group was superior in finding the platform where they required a noticeable shorter time to hit the platform(p<0.009). Also, animals in the LR group steered a shorter distance to find the target than did the LD animals(p<0.034). While the two groups elicited a considerable difference during the first half of the experiment both LR and LD rats demonstrated a similar behavior over the second half of the study. Conclusion: The light deprivation negatively influences the spatial navigation in water maze so that the visually deprived rats show less ability in searching the maze based on the spatial cues.

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Background: Skin cancer is one of the most important cancers in the world. This cancer is more common in men than women. We survey chromosomal changes in DMBA-induced skin cancer in SD rat strains. Methods and Materials: In this fundamental study, 20 SD rat strains were randomly divided into case and contal group. DMBA (2.5 mg) was injected to SD rat strains subcutaneously therefore skin cancer model for studies was created. Tumors became subjects for cell culture and metaphase chromosomal were prepared. Finally G-banding were stained. We have also transmitted genomic information from rat to human using suitable databases and Gene were determined. Results: Data showed numerical and frequent structural changes in different number of chromosomes. For example gain in chromosomes number 1, 15, 17 and loss in 1, 7, 15, and also structural changes like deletion was seen in chromosomes number 1, 4, 8, 10, 15, 17, and addition in chromosome number 15. Discussion: It is predicted that CST6، PRKCDBP، PTCH1، DKK3، ، BRMS1، CDKN1C، CD81، DMP1، CDKN2B ، EEF1A1 ، HRAS، CASP2، KLF4 probably cause skin cancer.

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Abstract Background: Different studies have shown the inability of traditional lecture method to active teaching method in concept transmitting of higher learning domain. The aim of this study was comparing the effects of feedback lecture method and conventional lecture method on learning and quality of teaching. Materials and Methods: In quasi-experimental study, 27 Arak medical science midwifery students who were in fourth semester, randomly, were divided to two groups of “teaching by feedback lecture” and “teaching by conventional lecture”. Desired topic were presented by one teacher as a 90- minute lecture in control group and as two 35-minute lectures with 10-minute discussion after each part in case group. Informational form, and post test and student' opinion form were used respectively to identify the demographic characteristics, short tem and long term learning and quality of teaching form. Results: Demographic characteristics, quality of teaching form student’s opinion, total scores of pre and post test were similar in two groups. Results of teaching score in post test in knowledge and perception level were similar. But there was a significant difference between application and analysis level in two groups(p=0.011). Also, total and domain scores of post test after a month were not different in both groups. Conclusion: Results indicated that learning by feedback lecture can be more effective than conventional lecture method in application and analysis domain.