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Showing 4 results for Yousefichaijan
Online Conductivity Monitoring, despite underestimating hemodialysis adequacy: Still a reliable practical tool
Mahnaz Edalat-Nejad, Rezvan Sadeqi, Parsa Yousefichaijan, Mahdie Qaffari,
Volume 15, Issue 9 (February 2013)
Abstract
Background: Adequately delivered hemodialysis dose has been shown to have a distinct impact upon the morbidity and mortality of patients on chronic dialysis therapy. Online conductivity monitoring (OCM) using sodium flux as a surrogate for urea allows for repeated measurement of hemodialysis adequacy in each treatment session. Materials and Methods: In this cross-sectional study, 156 treatment sessions in patients undergoing chronic hemodialysis were assessed by measurement of the conductivity performed by Diascan in AK 96 dialysis machines. Dialysis adequacy was measured by daugirdas logarithmic estimates of single-pool Kt/V. Values of calculated Kt/V and simultaneously obtained online Kt/V were compared. Statistical analysis was performed using paired sample t-test. Results: There was a statistically significant difference between calculated Kt/V and online Kt/V in this study. The mean calculated Kt/V was 1.1±0.18 and mean online Kt/V was 0.77±0.32 (p<0.001). There was a moderate correlation between calculated Sp Kt/V and on-line Kt/V (r =0.44, p=0.012). Conclusion: Despite the underestimation of hemodialysis adequacy by online conductivity monitoring in comparison with Sp Kt/V, it is a useful tool in clinical practice.
Comparison between Antipyretic Effects of Acetaminophen and Ibuprofen Monotherapy with Alternative Regimen of Both Drugs in Children Aged 6 Months to 12 Years
Parsa Yousefichaijan, Mahdieh O Sadat Ghafari, Hasan Taher Ahmadi, Leila Farajzadeh, Azam Zamamiyan,
Volume 17, Issue 4 (7-2014)
Abstract

Background: Pediatricians frequently confront with elevated body temperature in children and subsequent anxious parents. They practice several approaches in management of fever. A recently addressed issue is administration of alternating doses of acetaminophen and Ibuprofen. This method is relatively common , despite lack of sufficient evidence in this field.

Materials and Methods: This study is a randomized clinical trial. A total of 240 children, aged 6 months to 12 years suffering from gastroenteritis was recruited in this research. Children were classified in 3 groups. First group received Acetaminophen, second group received Ibuprofen and third group were treated with acetaminophen – Ibuprofen every other day alternately.

Results: 240 child were taken apart in this research . 112 ones were female (46.66%) and 128 were male (53.33%). The mean time of lowering fever in the first group was 2.07 days. This figure in the second and third groups were 1.82 and 1.87 respectively. Average doses in the first, second and third groups were (in order) 9, 8.17 and 7.13 doses. Medication in the first group minimum effectiveness rather than two other groups.

Conclusion: The alternating regimen of Acetaminophen – Ibuprofen is more effective than monotherapy in reduction of fever in infants and children between 6 months to 12 years.


Nephrotic Syndrome in Children with This Condition
Masoud Rezagholizamenjany, Parsa Yousefichaijan,
Volume 21, Issue 7 (2-2019)
Abstract
Nephrotic syndrome
Nephrotic syndrome is a manifestation of glomerular disease as a proteinuria in the nephrotic and triad of hypoalbuminemia, edema, hyperlipidemia, and high protein in the urine. Nephrotic proteinuria is defined as protein excretion of more than 40 mg/m2 of body surface per hour or protein to creatinine ratio of more than 2-3 at the first morning urine sample. Its annual incidence in most western countries is 2-3 cases per 100000 children per year, and in developing countries it is often higher due to malaria (1). New findings in this area are often about treatment, which are evaluated and reviewed in following.

Protective Effects of Vitamin C Concomitant Treatment on Deferasirox-induced Renal Toxicity in Rats
Taha Fereydouni, Saeed Hajihashemi, Parsa Yousefichaijan, Ali Rahbari,
Volume 23, Issue 6 (February & March 2020)
Abstract
Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression. Deferasirox, due to oxidative stress and increased cell apoptosis causes the dysfunction of renal tubules and renal toxicity. According to its antioxidant and anti-inflammatory properties, the present study explored the effect of vitamin C on deferasirox-induced kidney damage.
Methods & Materials: This study was performed on 30 Wistar rats in 3 groups of control, deferasirox, and deferasirox plus vitamin C. To induce the nephrotoxicity, the intra-peritoneum injection of deferasirox (75 mg/kg/day) was used. After taking plasma from the blood samples of the explored rats, we determined the values of Cr, Na+, K+, Mg+, osmolality, and BUN in the obtained plasma and urine samples. The creatinine clearance, as well as the relative and absolute excretion of sodium and potassium, were also calculated. After separating the two kidneys, they were used for the histologic study with Hematoxylin and Eosin (H&E) staining, as well as Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP)  biochemical studies.
Ethical Considerations This study was approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1396.309).
Results: Cotreatment with deferasirox and vitamin C reduced renal tissue MDA and relative and absolute Na and K excretion and urine osmolarity; this method also increased creatinine clearance and renal tissue FRAP.
Conclusion: The co-administration of vitamin C presented a significant protective effect on the renal toxicity induced by deferasirox. The protective property of deferasirox is because of the antioxidant impacts of vitamin C in reducing oxidative stress and lipid peroxidation. 

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