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Introduction: Glutatathion  s-transferases  (GST)  are  enzyme  encoded  by  a  multigene  family  and  have  important  roles  in  detoxification  of  some  strong  carcinogens. Human  GSTs are  categorized  into  four  groups.  Namely  π، μ، α، θ GSTM!  Is  a  member  of  GST  m  previous  studies  revealed  that  absence  of  GSTM1  protein  associates  with  increased  risk  of  development  of  several  malignancies.
Material  and  Method:  In  the  current  study, the  relationship  between  GSTM1  genetic  polymorphism  and  the  susceptibility  for  being  involved  by  gastric  carcinoma  was  explored.  Forthy  patients  with  gastric  carcinoma  and  80  normal  individuals  (control  group)  were  studied.  GSTM1  genetic  polymorphism  between  exons  5  and  6  was  explored  using  a  PCR  technique. For  each  patient  a  questionair  including  gender, age, cigarette  smoking, habit, and  history  of  neoplasia  in  first-degree  relatives  was  completed.
Results:  The  relative frequencies  of  null  genotype  in  the  control  group  and  gastric  cancer  were  31.25  and  60%  respectively. There  was  a  statistically  significant  (x2=9.21; p<0.05)  assessment  between  GSTM!  Null  genotype  and  development  of  gastric  carcinoma.
Conclusion: Not  mentioning  the  GSTM1  genotype,  cigarette  smoking  and  a  positive  family  history  had  significant  correlations  with  development  of  stomach  malignancy.

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Background and Aim: Diabetes is a well-known disease with such complications, as retinopathy, nephropathy, and gastropathy. This study aimed to investigate the effects of thiamine and lead acetate on the colon of induced-alloxan diabetic rats; the effects of which become obvious in the treatment or reduction of tissue complications caused by diabetes.
Methods & Materials: In this study, 63 rats weighing 200 g were divided into 9 groups, as follows: 1) Group of diabetes+pb acetate 200 ppm; 2) Group of thiamin+pb acetate 200 ppm; 3) Group of thiamine+pb acetate 1000 ppm; 4) Group of diabetes+thiamine+Pb acetate 1000 ppm; 5) Diabetes group; 6) Group of diabetes+thiamine; 7) Group of diabetes+thiamine+acetate 200 ppm; 8) Group of diabetes+pb acetate 1000 ppm, and 9) the control group. After 20 days, the study samples were removed from the abdominal cavity and the slides were prepared by routine tissue method. Then, the slides were evaluated for stereological and histomorphometric studies.
Ethical Considerations: This study was approved by the Faculty of Veterinary Medicine, Shahrekord University (Code: GRN1M1903). Moreover, all methods used in the present study, including facilitation, were conducted per the ethical principles of animal restraint.
Results: The mean thickness of mucosa-sub-mucosa suggested significant differences in groups 6 and 7, compared to other treatment groups. There was a significant difference in the thickness of the muscle layer between the control and all treatment groups except for groups 2, 6, and 7. There was no significant difference in the mean thickness of advantia layer in groups 1, 7, and 8, and the control group. The obtained results also indicated a significant difference concerning different layers of colon tissue between group 1 and controls.
Conclusion: Based on the present research results, thiamine presented enhancing effects on muscle layer thickness and adventitia layer thickness. Furthermore, the area of the mucosal layer was not affected by the improving effects of thiamine.