Showing 5 results for Vaziri
Hassan Izanloo, Mohammad Ahmadi Jebelli, Shahram Nazari, Navid Safavi, Hamid Reza Tashayoe, Gharib Majidi, Mohammad Khazaei, Vahid Vaziri Rad, Behnam Vakili, Hussein Aghababaei,
Volume 17, Issue 9 (12-2014)
Abstract
Background: This study aimed to examine the antibacterial effect of Polyamidoamine-G4 dendrimer on Escherichia coli, Enterobacter cloacae, Bacillus subtilis and Staphylococcus aureus.
Materials and Methods: In this experimental study, the antibacterial effects of Polyamidoamine-G4 dendrimer were studied by disc diffusion and micro-dilution method. Different concentrations of Polyamidoamine-G4 inoculated onto blank disks and were placed in Mueller-Hinton agar media. Zone of inhibition was investigated by bacterial inoculation according to the McFarland standard 0.5. Minimum inhibitory concentration and minimum bactericidal concentration of Polyamidoamine-G4 dendrimer were determined by micro-dilution method in nutrient broth culture.
Results: Zone of inhibition in concentration 500 &mug/ml of Polyamidoamine-G4 dendrimers for Escherichia coli, Enterobacter cloacae, Bacillus subtilis and Staphylococcus aureus were 14, 0, 35 and 29mm, respectively. Concerning the Zone of inhibition in gram negative bacteria with gram positive ones was p<0.05 and had significant difference. The minimum inhibitory concentration of Polyamidoamine-G4 dendrimer for Escherichia coli, Bacillus subtilis and Staphylococcus aureus were 1250, 2.5, and 1 &mug/ml, respectively. The minimum bactericidal concentration of Polyamidoamine-G4 dendrimer belonged to Escherichia coli, Bacillus subtilis and Staphylococcus aureus were 2500, 5 and 5 &mug/ml, respectively. Polyamidoamine-G4 dendrimer had not bacteriostatic and bactericidal effects on Enterobacter cloacae.
Conclusion: According to the results, Polyamidoamine-G4 dendrimer can eliminate Escherichia coli, Staphylococcus aureus and Bacillus subtilis effectively. It is suggested in the rest of this study that the probable toxicity of nanostructured compounds examined in drinking water and, economic studies is done for synthesis and their applications in case of prevention of using.
Zakieh Ghorbani, Hamid Reza Vaziri, Ziba Zahiri,
Volume 18, Issue 2 (5-2015)
Abstract
Background: Nowadays, the decline in birth rate is one of the most important social problems in developing societies. Infertility is defined as a failure to conceive in a couple trying to reproduce after one year of regular intercourse without contraception. Leptin have been implicated in maintaining normal female reproductive functions, including lactation, folliculogenesis, ovarian steroidogenesis, the maintenance of mammary gland morphology, the development of dominant follicles and oocytes, the maturation of the uterus endometrium, and menstrual cycle regulation. Sinyle-nucleotide polymorphism T>C found in exon 3 leads to substitution of Arg>Trp at codon 1.5 (R105W). In this case-control study, we aimed to evaluate the association of this polymorphism and the risk of female infertility in the population of Guilan.
Materials and Methods: Blood Samples were collected from 86 patients diagnosed with female infertility and 60 control subjects, and genotyped by allele-specific PCR (AS-PCR). To estimate the association between genotype and allele frequencies in cases and controls, Chi-Square analysis was used.
Results: Analysis revealed no significant differences were found in genotype and allele distributions of LEP Arg105Trp between infertility cases and controls (p=0.21, p=0.2) in this population.
Conclusion: Our findings indicated no significant association between the Arg105Trp polymorphism and female infertility risk (p=0.21). While, more studies are needed to confirm the results.
Sheyda Jodeiry, Hamid Reza Vaziri, Ziba Zahiri,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Infertility is a multifactorial disorder with genetic and non-genomic factors. It is estimated that female infertility factors accounts for more than 40%. Estrogen is one of the effective hormons in fertility. Its crucial actions on target tissues are mediated via binding to estrogen receptors(ESR). The ESR1 gene is located on chromosome 6q25.1 and encodes α estrogen receptor. The aim of this study was to analysis of ESR1 rs104893956 polymorphism in female infertility.
Materials and Methods: In this case-control study, of 60 infertiles and 55 healthy controls, blood samples were attained. After the extraction of genomic DNA from peripheral blood leukocytes, Allele Specific-PCR (AS-PCR) method was applied for determining the codon polymorphism. Statistical analysis was performed using the MedCalc software (Version 12.1).
Results: The frecuency of T allele was significantly higher in patients (58%) than the controls (44%). There was higher frequency of TT genotype of the polymorphism in patients (18.33%) compared with controls (1.8%). Our findings revealed that the patients carrying the TT genotype had a significant increased risk of infertility.
Conclusion: The results of this study suggests that ESR1 rs104893956 polymorphism may affect the increased susceptibility to female infertility in Guilan province. The results may be different in other genetic pools or large-studied population.
Haniyeh Mozafari, Farah Lotfi Kashani, Shahram Vaziri, Mohammad Ismail Akbari,
Volume 27, Issue 3 (7-2024)
Abstract
Introduction: The present study was conducted to analyze the focal relationship of the contribution of mental adaptation to cancer, health literacy, and perceived threat in predicting the early diagnosis of breast cancer.
Methods: This study was a descriptive correlational research. The statistical population of the present study included all women with breast cancer under treatment at Shohadaye Tajrish Hospital Cancer Treatment Center in 2023, and 310 people were determined to participate in the research using G*Power software and the available sampling method. They responded to Williams, Templin, and Hines's breast cancer literacy questionnaires, Champion's perceived threat questionnaire, Watson's mental adaptation to cancer and early diagnosis questionnaire. The data were also analyzed using a focal correlation test and multiple regression.
Results: The results showed that there is a significant relationship between the contribution variables of mental adaptation, perceived threat, and health literacy with the components of early cancer diagnosis (knowledge, attitude, and actions) (P ≤ 0.01). Also, the results showed that health literacy was 4.8%, mental compatibility was 3.4 percent and perceived threat 18.7% alone predicted the variance of early diagnosis of breast cancer. The perceived threat share is 38.9%, higher than all other variables.
Conclusions: Based on the statistical results, it can be said that increasing mental adaptability, perceived threat, and health literacy play a role in early disease diagnosis, and the importance of perceived threat is more significant than mental adaptability and health literacy, which should be considered.
Fatemeh Sadat Fatemi, Aezam Vaziri Nasab, Dr Farshid Khosropour,
Volume 28, Issue 5 (12-2025)
Abstract
Introduction: Today, marital infidelity has a significant prevalence among couples, necessitating appropriate interventions to address this destructive behavior. Therefore, the present study was conducted with the aim of comparing the effectiveness of reality therapy (RT) and acceptance and commitment therapy (ACT) on depression and anxiety in women affected by marital infidelity.
Methods: The current research was a semi-experimental study employing a pretest-posttest design with a control group. The statistical population included all women affected by marital infidelity who referred to counseling centers in Kerman city in the first half of 2024. Among these women, 45 were selected as a sample and were randomly assigned to two experimental groups and a control group (15 participants each) by drawing lots. The first experimental group received reality therapy intervention and the second group received ACT intervention, both comprising eight 60-minute sessions. The research instruments were the the Lovibond and Lovibond (1995) depression and anxiety questionnaires. Data were analyzed using repeated measures ANOVA and Bonferroni post-hoc tests.
Results: The results showed that both Reality Therapy and Acceptance and Commitment Therapy were effective in reducing depression and anxiety. Furthermore, Acceptance and Commitment Therapy demonstrated significantly greater effectiveness than Reality Therapy in reducing depression and anxiety among women affected by infidelity (P < 0.001).
Conclusions: The findings of the present study showed that Bonferoni therapy is a more appropriate approach to reduce the harm caused by marital infidelity in women. The main emphasis of this therapy is on cognitive dissonance, the exercises of which make thoughts less anxiety-provoking.
