Journal of Arak University of Medical Sciences

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The comparison between two treatment methods for H. pylori eradication with two-week sequential regimens

Majid Moghadaszadeh, Ebrahim Fattahi, Mohamad Hosein Somi, Manochehr Khosh Baten, Toraj Rosta,
Volume 15, Issue 2 (June-July 2012)

Abstract

Background: H. pylori infection is common worldwide involving 50% of the general population. The aim of this study was to compare the effect of two sequential regimen therapies on the eradication of H. pylori. Materials and Methods: In this clinical trial, 150 patients were allocated to two groups of 75 each: group A and group B. The eradication of H. pylori in groups A and B was based on azithromycin and ofloxacin sequential regimens, respectively, and the results were compared between the groups. The data were analyzed by t-test, Chi-square test, and Fisher’s exact test using SPSS software version 16. Results: Mean of the patients’ age was 39.3± 1.2 within the age range of 18 to 85 years. There were not significant differences between the two groups considering the type of peptic ulcer. In group A, Urea Breath Test (UBT) was negative in 67 (89.3%) patients while in group B, it was only positive in 8 (10.7%) patients. In group B, there were 64 (85.3%) negative and 11 (14.7%) positive UBT test results. There were no significant differences in H. pylori eradication rates between the two groups (P=0.31). Conclusion: Noticing the absence of a significant difference between the two groups in terms of H. pylori eradication, it can be concluded that ofloxacin-based drug regimens have no superiority over azithromycine-based regimens and each regimen can be prescribed considering drug complication rates in different patients.

The Effectiveness of Combined Treatment Based on Virtual Reality and Mindfulness on Cortisol Levels in Individuals with Generalized Anxiety Disorder

Toktam Masomi, Doctor Gholamreza Manshaee, Doctor Hadi Farhadi,
Volume 26, Issue 5 (December & January 2023)

Abstract

Introduction: This research aimed to investigate the effectiveness of combined treatment based on virtual reality and mindfulness on cortisol levels in individuals with generalized anxiety disorder.
Methods: The study employed a semi-experimental design with a pre-test-post-test control group and a two-month follow-up period. The study population included all individuals with symptoms of generalized anxiety disorder who referred to the clinics of the Psychological Services Center and Counseling in Region 3, the Counseling and Psychological Services Center of Welfare in Region 6, and the Aryaz Counseling and Psychological Services of Region 6, Tehran, from April 2022 to the end of autumn 2022.
Results: The sample consisted of 30 individuals (10 males and 20 females) with generalized anxiety disorder, selected purposefully and randomly assigned to a treatment group based on virtual reality and mindfulness (15 individuals) and a control group (15 individuals). Pre-test, post-test, and follow-up cortisol levels were measured, and the Generalized Anxiety Disorder 7-item scale (GAD-7) was used as the entry criterion. Subsequently, the experimental group received an eight-session, 17-minute weekly treatment based on virtual reality and mindfulness. Participants in this group, while immersed in a virtual environment, watched 360-degree virtual reality videos, "Walking by the Beach" and "Pebbles in the Lake," accompanied by mindfulness audio contemplation, "Being Present and Breathing," and "Wise Mind," using a VR headset and VR-ARBOX. The control group received no treatment.
Conclusions: After completing the interventions, post-tests and two-month follow-ups were conducted. The data were analyzed using repeated measures analysis of variance (ANOVA) with SPSS23 software, revealing that the combined treatment based on virtual reality and mindfulness was effective in reducing cortisol levels. It is suggested that this combined method is used as a clinical intervention in order to reduce the level of anxiety and cortisol of people suffering from generalized anxiety disorder alone or along with other psychological and pharmaceutical interventions.

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