Showing 5 results for Siavash
Afsane Talali, Masoud Amini, Maryam Zare, Mansour Siavash,
Volume 10, Issue 3 (6-2007)
Abstract
Introduction: Dehydroepiandrostrone (DHEA) and its sulfate form is an adrenal hormone and is the most common steroidal hormone in body and despite of other adrenal hormones increases with age, so it is called youth fountain. Recently, DHEA is noticed increasingly because of its multiple effects. Its effect on insulin sensitivity is controversial. In this study the relation between Dehydroepiandrostrone (DHEA) level and Insulin sensitivity is investigated. Materials and Methods: In this cross-sectional analytical study, samples were selected among female relatives of diabetic patients referring to Isfahan Endocrine Research Center. They were divided into three groups including diabetic, impaired glucose tolerance and normal glucose tolerance, each 30 persons. In these groups blood sugar, lipid, CBC, Insulin and DHEA-S levels were evaluated and the rate of Insulin sensitivity was determined using Homeostatic Modle Assessment- Insulin Resistance (HOMA-IR) and the relation between insulin sensitivity rate and DHEA in the three groups was compared. Data was analyzed using one way analysis of variance and t-tests. Results: The mean of variables in the three groups of diabetic, impaired glucose tolerance and normal glucose tolerance for DHEA-S was 127, 113, 129 mcg/dl Insulin 7.7, 1.10, 8.3 mcg/ml HOMA-IR 1.6, 3.5, 1.8 and fasting blood sugar 86, 135, 89 mg/dl respectively. Comparison of mean of variables showed that the difference between DHEA-S in groups was not significant. Also there was no meaningful relationship between DHEA-S and blood sugar. In the group with normal glucose tolerance, DHEA-S with HOMA-IR and insulin had a partial meaningful relation (p<0.06). Conclusion: Overally DHEA has no meaningful relation with insulin sensitivity and HOMA-IR, but this relation is meaningful in the three groups and the relation between DHEA-S with HOMA-IR in the group with normal glucose tolerance is partially meaningful.
Masoud Motamedi, Abbas Atari, Mansour Siavash, Fereshte Shakibaii, Mohamad Masoud Azhar,
Volume 10, Issue 4 (12-2007)
Abstract
Association between biological factors and disruptive behaviors in children and adolescents is important to investigate. Antisocial, aggressive and delinquent behaviors in adults often begin early in life. Basal cortisol is a valuable biological characteristic of children with disruptive behavior disorder (DBD). In this study the effect of family training on basal salivary cortisol in children with DBD was investigated. Materials and Methods: This is a clinical trial study. Basal salivary cortisol levels were studied in 19 children between 8-13 years old with DBD, before and 2 months after intervention (family training). The disruptive behavior of the child was assessed with child behavior checklist (CBCL). Cortisol levels and score of behavior were compared before and after intervention. Data was analyzed using descriptive statistics, paired t-test and pearson correlation. Results: Salivary cortisol before family training was 7.9±4.6 nmol/L and after that was 10.46±3.84 nmol/L which was significantly different (p<0.001). Behavior score before intervention was 72.05±10.10 and after that was 49.361±1.89 that was also significantly different (p<0.0001). Children with lower basal salivary cortisol had a better response to intervention. Conclusion: Parent training is an effective method for behavioral modification in DBD. Salivary cortisol can be considered as a predictive factor for severity of disruptive behavior, also a factor to assess the response to parent training in children with DBD.
Siavash Fazelian, Ahmad Saedi Someeh Olia, Mrayam Mirftahi, Mostafa Hoseini, Haleh Sadrzade Yegane, Javad Heshmati, Nazli Namazi,
Volume 16, Issue 9 (12-2013)
Abstract
Background: Considering that pre-diabetes is one of disorders that increases developing of diabetes, this study was performed to investigate the effect of L-Arginine supplementation on antioxidant enzyme activity, total antioxidant capacity, and body composition in patients with pre-diabetes.
Materials and Methods: A double-blinded randomized clinical trial was performed on 46 pre-diabetic patients. Patients in intervention (n=23) and placebo groups received 3g/day L-arginine and placebo (three 1gr L-arginine capsules), respectively for 8 weeks. Anthropometric, body composition, and dietary intake assessments, and also biochemical tests were done at baseline and end of study. Total Antioxidant Capacity (TAC), glutathione peroxidase enzyme and superoxide dismutase activity were measured. Paired t-test, independent t-test and ANOVA were used to analyze quantitative variables.
Results: Thirty eight patients (19 subjects in each group) completed the study. After adjusting confounding factors, no significant difference in body composition, anthropometric indices and dietary intake was observed at the end of study (p<0.05 in all factors), but a significant difference in TAC level was observed in the intervention group at the end of study (p<0.001).
Conclusion: Supplemenation with 3gr/day L-arginine for 8 weeks led to raised serum TAC level without changes in body composition in pre-diabetic patients.
Narges Ensan, Isaac Rahimian Boogar, Siavash Talepasand, Fariborz Estilaee,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Multiple Sclerosis (MS) is an unpredictable disease that can change individuals' lifestyle. The purpose of this study was to investigate the effect of a Mindfulness-Based Stress Reduction (MBSR) program on functional disability of patients with MS.
Methods & Materials The is an experimental study with pre-test/post-test/follow up design using control group. The study population consisted of all male and female patients with MS living in Neyshabur county, Iran. Of these, 47 were selected using a convenience sampling technique and randomly assigned into two groups of intervention (n=22) and control (n=25). The intervention group received MBSR therapy for 8 sessions, while the control group received no intervention. The follow-up was performed after one month. Subjects’ functional disability was measured by using the World Health Organization Disability Assessment questionnaire. The collected data were analyzed using SPSS v.21 software usingrepeated measurements Analysis of Variance (ANOVA).
Ethical Considerations This study obtained its ethical approval from the Research Ethics Committee of Neyshabur University of Medical Sciences (code: IR. NUMS.REC.1397.004)
Results The results of univariate ANOVA showed the significant effect of time and the interaction effect of time and group on functional disability of samples. The results of between-group ANOVA a significant difference between the intervention and control groups in functional disability (p <0.05). Pairwise comparison of the interaction effect of time and group showed a significant difference between the pre-test, post-test and follow-up scores (P = 0.001), but no significant difference was reported between the post-test and follow-up scores.
Conclusion The MBSR program could reduce the functional disability in patients with MS due to ease of treatment, faster patient education, and the short duration of intervention sessions.
Ahmad Ansarifar, Isaac Rahimian-Boogar, Siavash Talepasand,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: Sociodemographic factors and perceived anxiety have a significant impact on the development of somatic symptom disorder. This study aimed to investigate the role of demographic characteristics, social isolation, and perceived anxiety in predicting somatic symptom disorder.
Methods: In a cross-sectional descriptive study among adults aged 18 to 60 in Tehran in 2023, 437 participants were selected based on convenience sampling. The participants completed the Somatic Symptom Disorder Questionnaire (SSEQ), Social Isolation Questionnaire, and Perceived Anxiety Questionnaire. Data were analyzed using Pearson’s correlation and multiple regression analysis.
Results: The results indicated that social isolation and perceived anxiety have a positive and significant correlation with somatic symptoms disorder (P < 0.01). There was no correlation between demographic characteristics (age, gender, marital status, education, and employment status) and somatic symptoms (P <0.01). Multiple correlation and regression coefficients among research variables were statistically significant (P < 0.01).
Conclusions: The examined model was almost able to predict 22% of the somatic symptoms of the disorder. The results have implications for formulating interventions based on social isolation and perceived anxiety in controlling somatic symptoms. It is essential to pay attention to social isolation and perceived anxiety in the formulation and implementation of interventions and educational programs for the prevention and improvement of somatic symptom disorder.
