Ali Fani, Parisa Fani, Mohammad Rafiei, Navid Reza Mashayekhi, Reza Shahmirzaei, Khosro Minavand,
Volume 13, Issue 1 (4-2010)
Abstract
Background: Aspirin (ASA) and helicobacter pylori infection are two major known risk factors for peptic-ulcer. This research aims to examine the interaction between helicobacter pylori and low dose ASA in inducing gastro-intestinal complications. Materials and Methods: The target group consisted of patients with cardiovascular disease who were under low dose ASA therapy. Patients, who had symptoms of dyspepsia, were placed in the case group and those who did not have these symptoms were placed in the control group. 5cc blood samples, required for conducting ELISA Ab., were taken simultaneously in both of the groups. ELISA positive patients underwent UBT test. UBT positive patients were categorized as helicobacter pylori positive and those with negative UBT were placed in the helicobacter pylori negative group. Finally, the ratio of dyspepsia incidence probability to Aspirin usage and helicobacter pylori infection was analyzed. Results: Of the 129 individuals present in the control group and 71 individuals who were in the case group, 72(36%) were UBT positive, and the rest were UBT negative. Of all the patients, 35.5% had dyspepsia and there was a significant difference between UBT positive and UBT negative individuals (p=0.001, OR=6.54). of 43 patients who had signs of intensified dyspepsia 23 persons under went endoscopy assessment which 20 of them were diagnosed with peptic ulcer. Eighty percent of the patients who had developed peptic ulcer, were UBT positive which revealed a significant difference with UBT negative (p=0.001, OR=8.86). Conclusion: In order to reduce gastro-intestinal complications, it is suggested that long term low dose Aspirin takers be subjected for screening and to receive treatment in terms of infection with helicobacter pylori and clinical manifestations.
Reza Shahmirzaei, Saeed Sadrnia, Hassan Solhi, Ali Ghasemi,
Volume 13, Issue 2 (6-2010)
Abstract
Background: Positive electrocardiogram (ECG) changes in patients with unstable angina or non-ST elevation myocardial infarction are well known, but problem arises when no specific changes in ECG are identified. The aim of this study is to evaluate the prevalence of these changes in hospitalized patients at Amir Kabir Hospital of Arak. Materials and Methods: This study was a cross-sectional one that was conducted on 124 patients hospitalized at the heart emergency ward of Arak Amir Kabir Hospital with unstable angina and non-ST elevation myocardial infarction. ECG changes and serum cardiac enzyme levels were analyzed on admission and 12 hours after admission. Results: According to patients’ history and serum cardiac enzymes, 62 patients had undergone myocardial infarction without ST segment elevation, 98.4% of whom had ECG changes and 1.5% showed no ECG changes. Of the 60 patients, who had been hospitalized with unstable angina, 90% showed ECG changes and the rest 10% revealed no such changes. Conclusion: In comparison to other studies reporting that 50% of patients with unstable angina and non ST elevation myocardial infarction reveal no ECG changes, a high percentage of patients referring with a chest pain to the heart emergency ward of Amir Kabir Hospital, had no significant changes in their ECG and were not hospitalized.
