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Background and Aim: Exercise aerobic is associated with increased creatine kinase and blood lactate immediately after exercise, leading to increased muscle damage and undesirable changes in many cellular markers including serum creatine kinase. In such situations, consuming nutrients and supplements such as coenzyme Q10 may prevent metabolic stress damage by increasing buffering power. However, comprehensive studies have not been performed on the effects of this nutrient on the index of muscle injury and fatigue caused by exercise.
Methods & Materials: For this purpose, 20 inactive volunteer men were randomly divided into two groups of 10-person Coenzyme Q10 supplement (2.5 mg/kg body weight) and quasi-drug (2.5 mg/kg body weight Dextrose). All subjects participated in the Bruce test exercise contract after 14 days of supplementation. Blood sampling was performed in four stages including baseline, after supplementation, immediately after exercise and two hours after exercise. Creatine kinase, lactate and cortisol indices of both groups were measured during these four stages. Data were analyzed by means of standard deviation and repeated measures ANOVA, Bonferroni post hoc and Independent T-test using SPSS V. 17 at the significant level of 0.05.
Ethical Considerations: This article has been approved by the ethics committee of Tabriz School of Medical Sciences with the ethics code IRCT 201203104663N8.
Results: The results showed that 14 days of Coenzyme Q10 supplementation had a significant effect on cortisol level (P<0.05). In addition, one session of exhausting aerobic activity increased creatinine kinase and lactate (P<0.05). On the other hand, creatinine kinase did not differ significantly after exercise (P>0.05). 
Conclusion: According to the results of the present study, 14-day supplementation of Coenzyme Q10 may reduce the cellular damage induced by exhaustive aerobic activity in inactive men and prevent an increase in blood lactate levels.

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Introduction: Reducing physical activity as well as consuming more calories than the body needs increases obesity and its related disorders, such as metabolic syndrome. Therefore, this study aimed to determine the effect of eight weeks of high-intensity interval training (HIIT) and resistance training (RT) on brain tissue gene expression of AKT2 and insulin resistance in obese Wistar rats.
Methods: 30 male rats weighing 160 to 185 grams were fed a high-fat diet for 12 weeks. After the approval of the obesity protocol of increasing the weight of the rats, which to be more than 300 grams, the rats were divided into three groups, including the control group (n = 10), HIIT group (n = 10), as well as RT group (n = 10). Until the end, the rats continued to eat a high-fat diet. HIIT was performed for eight weeks and five sessions per week, with an intensity of 80 to 95% of maximum oxygen consumption on a treadmill. Moreover, RT was performed with an intensity of 40-60% of a maximum repetition on the ladder. After eight weeks of training interventions, the expression level of the AKT2 gene in brain tissue was measured by the real-time PCR method.
Results: The results of the present study demonstrated a significant increase in AKT2 gene expression of HIIT and RT groups compared to the control group (P < 0.05). Furthermore, the results illustrated that the insulin resistance of rats in both training groups was significantly reduced (P < 0.05).
Conclusions: According to the findings of the present research, it could be concluded that HIIT, as well as RT interventions, probably causes an increase in AKT2 gene expression and could be effective in reducing insulin resistance and improving glucose profile.