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Showing 2 results for Saraei

Jamal Saraei, Zahra Esmaeli, Zahra Tajari, Shadi Khodayarnezhad, Aref Nekofar, Mahdieh Abbasalizad Farhangi,
Volume 18, Issue 10 (1-2016)
Abstract

Background: Under-nutrition has multiple negative impacts on child's growth and development and it has a high prevalence among hospitalized children. Assessment of the food insecurity status is one of the most important indicators of malnutrition among communities, therefore the aim of the current study is to evaluate the prevalence of food insecurity and its social, economical and nutritional determinants among children hospitalized in Tabriz pediatric hospital.

Materials and Methods: The current cross-sectional study was carried out among 236 hospitalized children in Tabriz pediatric hospital. Demographic information including age, weight, height, household size, child order and household income were gathered by face to face interviews with parents. Food security was assessed by a Household Food Security questionnaire. Statistical analysis was performed by Excel 2007, Epi-info and IBM SPSS Statistics 21 software.

Results: The prevalence of food insecurity among hospitalized children in Tabriz pediatric hospital was 44.9%, while 26.3% and 18.6% had moderately and severely food insecurity, respectively. Its prevalence in females was more than in males. Low household income, low educational attainment of parents, rural residency and household size were potent determinants of food insecurity(p<0.05). All indices of nutritional status in food insecure group were lower than in secure group. Although this difference did not achieved significant threshold.

Conclusion: In the current study, a high prevalence of food insecurity in hospitalized children in hospital has been reported. Therefore the need for suitable interventions to reduce its prevalence has been warranted.


Bozorgmehr Imani Pirsaraei, Najmeh Ranji, Leila Asadpour,
Volume 21, Issue 2 (5-2018)
Abstract

Abstract
Background: Pseudomonas aeruginosa is an opportunistic gram-negative bacterium that is a major cause of nosocomial infections such as severe burns. Curcumin is the main component of turmeric (Curcuma longa) that has anti-cancer and anti-inflammatory effects. The aim of this study was to evaluate antibacterial effect of curcumin in ciprofloxacin resistant isolates of Pseudomonas aeruginosa through mexC and mexD gene expression.
Materials and Methods: In this descriptive-analytical study, Pseudomonas aeruginosa strains were obtained from hospitals and laboratories in Guilan province. After disc difusion and MIC tests, four ciprofloxacin resistant strains of Pseudomonas aeruginosa were treated by ciprofloxacin (1/2MIC) only (control sample) and in the combination with curcumin encapsulated in micelle nanoparticles (test sample). After 24h, RNA extraction and cDNA synthesis was performed. Then, the expression of mexC and mexD genes was evaluated quantitatively by Real-time PCR method in curcumin treated and un-treated cells
Results: This study showed that combination of ciprofloxacin (1/2 MIC) with curcumin encapsulated in micelle nanoparticles led to approximately 50% of growth inhibition in Pseudomonas aeruginosa. In treated cells with curcumin and ciprofloxacin compared to treated cells with ciprofloxacin alone, mexC and mexD genes were significantly (p<0.05) downregulated >0.65 fold in three isolates and >0.1 fold in four isolates, respectively.
Conclusion: Our results suggested that curcumin encapsulated in micelle nanoparticles combined with 1/2 MIC value of ciprofloxacin inhibits the growth of Pseudomonas aeruginosa through reducing mexC and mexD expression.


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