Showing 15 results for Salimi
Saeid Changiz Ashtiani, Saeid Khameneh, Hamid Salimi Khaligh,
Volume 2, Issue 7 (Summer 1999)
Abstract
Arterial baroreflexes are the most important mechanism of cardiovascular control. These reflexes compared with other reflexes act so rapidly that can respond to rapid blood pressure changes during daily activities. In this study we have assessed the cardiac responses of cardiac baroreflexes dynamic exercise , and compared the results with acute response during rest exercise. It was 50% of calculated maximum force. Experiments were performed on 12 young male healthy sedentary volunteers isometric exercise(protocol B) and dynamic exercise (protocol C). In order to stimulate the carotid baroreceptors neck suction device Eckberg model was used , ECG were taken continuously during experiment. In protocol A (control group) after stimulation the cardiac cycle (R-R interval) from baseline reached to acute responses in the first beat induction baseline in the forth beat P<0.003 and in the protocol C reached acute response compared with baseline in the eighth beat after induction P<0.001. If the observed acute responses during test are compared and concluded that shorting R-R interval in response to isometric due to vagal withdrawal combined with an subtle sympathetic stimulation. This phenomenon is observed more strongly in dynamic exercise.
Saeid Changizi Ashtiyani , Saeid Khameneh, Hamid Salimi Khaligh ,
Volume 3, Issue 2 (Summer 2000)
Abstract
Arterial baroreflexes are the most important mechanism of cardiovascular system that can respond to rapid blood pressure changes during everyday activities. In this study we have assessed adaptive responses of carotid baroreflexes during isometric & dynamic exercise and compared the results with acute response during rest. The applied work loud in dynamic exercise was 100 watts and in isometric exercise it was 50% of calculated maximum force. Experiments were performed on 12 young male healthy sedentary volunteers aged between 21-28. This study was done in three exercises. In all three protocles, adaptation process during stimulation was assessed by studying of beat to beat R-R interval of ECG. In order to stimulate the carotid baroreceptors neck suction device Eckberg model was used and duration of stimulation was 10 seconds. ECG was taken carefully. Examination of adaptive process during stimulation showed maximal response achieved in resting state is statistically significant compared with that of isometric and dynamic exercise respectively (P<0.038, P<0.007). where as, comparison of adaptive response of rest state with isometric exercise and dynamic exercise was not statistically significant. There is no significant relation between maximal and adaptative response in dynamic and isometric exercises, although in general adaptative process in resting state compared with isometric and dynamic exercise was more pronounced. This observation confirmed that Vagal withdrawal with alimited degree of sympathic stimulation are challenged in this phenomenon. In other words the Sa response to vagal stimulation is related by sympathic stimulation.
Dr Mohammad Ali Zargar Shooshtari, Dr Abolfazl Golmohammadi, Dr Meysam Jamshidi, Dr Hormoz Salimi,
Volume 9, Issue 1 (3-2006)
Abstract
Introduction: Renal cell carcinoma can be presented with extension of thrombosis to renal vein and inferior vena cava. Management of these patients consists of radical nephrectomy and thrombectomy. In this study we reviewed approach to these patients. Materials & Methods: This is a case series report. During 1379 to 1384, 148 patients diagnosed with renal cell carcinoma (RCC) limited to Gerota’s fascia (stage T3 or less) were admitted to Hasheminejad hospital. Fourteen patients had inferior vena cava (IVC) involvement. Radical nephrectomy as well as thrombectomy was performed in 8 patients. This investigation is done on these 8 patients. Results: Patients' average age was 51.4 years. Six patients were male (75%) and 2 female (25%). The most common symptoms were flank pain (75%), gross hematuria (62.5%) and structural symptoms (50%). All patients had tumors limited to Gerota’s fascia without any distant metastasis. Infrahepatic involvement of IVC was seen in 6 patients and in 2 patients thrombosis extended above the hepatic vein (infrahepatic). No perioperative mortality was seen. Postoperative complications were atelectasia in 2 patients and deep vein thrombosis in one which was treated with conservative management. Conclusion:By skillful surgical approach in patients with RCC and IVC involvement, thrombosis can be completely excised without increasing the rate of complications and longterm survival could be expected.
Raziyeh Khalesi, Jafar Salimian, Shahram Nazarian, Zahra Ehsaei , Ali Asghar Rahimi, Nafiseh Amini, Seyed Mohammad Moazzeni,
Volume 15, Issue 1 (April-May 2012)
Abstract
Background: Enterotoxigenic Escherichia coli bacterium is the most important bacterial agent causing diarrhea. Specific virulence factors, such as enterotoxins and colonization factors, distinguish ETEC from other classes of diarrheagenic E.coli. In this study, heat-labile toxin was purified which could be utilized for anti-toxin assay in GM1 gangelioside receptor-ELISA based method and for identification of ETEC producing toxin.
Materials and Methods: In this experimental study, bacterial strain producing heat-labile toxin was first cultivated for production and purification of toxin. Then supernatant soluble proteins were precipitated with ammonium sulfate and purified using biochemical methods. Finally, purified protein was dialyzed against Tris 0.02 mM pH 8 and analyzed on gel electrophoresis. GM1 gangelioside receptor-ELISA based method was used for detection and assessment of the purified toxin. Through this method, the effect of anti-recombinant heat-labile toxin B subunit neutralization on heat-labile toxin was investigated.
Results: Toxin purification was revealed by the presence of 12 and 28 KD protein bands. This study demonstrated that anti-recombinant heat-labile toxin B subunit antibody can detect the purified toxin and can inhibit its binding to GM1 receptor up to 80%.
Conclusion: Purification of heat-labile toxin and gangelioside receptor-ELISA assay can be used for accurate detection and epidemiological study of clinical isolates.
Manizheh Jozpanahi , Afsaneh Karami, Firoozeh Salimi ,
Volume 16, Issue 11 (2-2014)
Abstract
Background: The Infections that are related to vascular access, are regarded as Important factor in mortality and morbidity in the patients with immune deficiency including hemodialysis patients. Staphylococcus aureus is the most common and most Important organism involved in this regard and it cause bacteremia and its complications in the patients is important. This organism can cause carriage states and its most frequent carriage source is in the nose. The aim of this study is determination of staphylococcal carriage states in the Zanjan hemodialysis patients and control group.
Materials and Methods: This cross sectional study is designed in the patients with chronic renal disease who were referred to the hemodialysis wards. Nasal samples were collected with sterile swabs. Then they were inoculated in the blood agar culture media and incubated at (35-37) degree for (24-48) hours. This method was taken for control group too. The collected data were analyzed with SPSS and Chi-Square statistically methods.
Results: Based on this study, 7.4 percent of patients and 11.1 percent of the control group were nasal carriers of staphylococcus aureus. The results did not show any meaningful statistically difference between the cases and control groups. But a meaningful statistically difference was observed in the Staphylococcus hemolyticus carriages and the nasal carriage of this organism was more common in the women of case group.
Conclusion: Based on our study, we don't find high prevalence rate of nasal staphylococcus aureus carriage among our case group, and It seems this organism isnot an important agent in our hemodialysis wards.
Pouran Karimi, Roshanak Bayat Makou, Parvin Dehghan, Mohamad Reza Salimi Movahed,
Volume 17, Issue 1 (4-2014)
Abstract
Background: Selenium is a unique trace element which is benefit on inflammatory underlining diseases. MAPK (Mitogen-activated protein kinase) pathways regulate several cellular functions including inflammation, cell differentiation, migration, and apoptosis. Objective: This study aimed to find out the pathway(s) by which Selenium modifies inflammatory events in oxidative or thrombotic induced stress in platelet.
Materials and Methods: This is a basic -experimental study on Human platelets obtained from 30 healthy individuals (age 35±12) .The phosphorylation rate of P38MAPK , c –JNK (c-Jun N-terminal Kinase), and ERK1/2(Extracellular signal-regulated kinases1/2) as three important proteins in MAPK family and P-selectin were measured in presence or absence of selenium by ELISA( solid phase sandwich Enzyme Linked-ImmunoSorbent Assay). Pharmacological inhibition is done by inhibitors of P38MAPK, ERK1/2 and c- JNK in order to compare with selenium effects. The percentage of ratio of phosphorylated to total protein was used for normalizing the phospho protein contents of platelets.
Results: Selenium significantly reduced P-selectin expression (p<0.05), P38MAPK (p<0.05) and c- JNK phosphorylation (p<0.05) induced by cu2+oxidized LDL in platelets but Se couldn’t significantly reduce Thrombin induced P-selectin despite of decreasing in mentioned phospho-proeins.
Conclusion: Our results indicated that Selenium can reduce inflammation via suppression of p38MAPK-dependent signaling pathway. These results may provide insights related to development of novel Selenium therapies in atherosclerosis.
Narges Barzegar, Alireza Saliminia, Esmat Danesh, Roghieh Nooripour,
Volume 17, Issue 10 (1-2015)
Abstract
Background: Celiac disease (CD) is an immune-mediated inflammation of the small intestine which caused by sensitivity to dietary gluten and related proteins in genetically sensitive individuals. This research aimed to investigate of comparison big five factors of personality and early maladaptive schemas among celiac people and normal people.
Materials and Methods: The research method was ex post facto and statistical population included all people with Celiac whose 108 patients were selected by convenient sampling and 108 normal people were selected by convenient in 4 universities of nursing, psychological, literature and accounting of Azad University in Karaj city. Both groups responded brief five factors questionnaire of NEO personality characteristics and Yang’s early maladaptive schemas. Data were analyzed by using independent t-test, analysis of variance and Multivariate Analysis of Variance, Ben Frooni test, Landa test Wickelz and SPSS version 19.
Results: Results indicated that from five main factors of personality, score of psycho -lesion of patient with celiac were more than normal people. Also, patient’s scores in early maladaptive schemas (emotional baffling, lack of trust, fault/shameless, social recluse/ strangeness, attachment/inefficiency, vulnerability toward loss or sickness, not self –maturing/ engaged, failure, fitness/modesty, self-denial, insufficient self-discipline, servitude, self –sacrifice/ aggressive criteria, extreme criticize and emotional inhibition) were higher in comparison with normal people.
Conclusion: This study revealed that according to influence of early maladaptive schemas on celiac sickness, psychological training courses and schema therapy in order to improve emotional and cognitive patterns of these patients.
Morteza Salimi Avansar, Abdolsaleh Zar,
Volume 20, Issue 2 (5-2017)
Abstract
Abstract
Background: The prevalence of obesity among children is alarmingly rising. Obesity in a chronical inflammatory condition accompanies with inflammatory markers such as Chemerin and CRP; therefore, the aim of this following study is to compare the affection of Endurance & High Intensity Interval Trainings on levels of Chemerin & Protein of C-reactive plasma in obese children.
Materials and Methods: This experimentation included 21 obese children (average weight 61.46±2.5 kg and BMI 7.1±4.31) aging 9-12 years old who were randomly divided into three groups of endurance, HIIT and control (n=7). The training groups performed regular exercises for 8 weeks long (3 sessions in every week). The differences between groups were evaluated using covariance analysis. (p<0.05).
Results: In both training groups, there was a more significant decrease in weight, BMI and body fat percentage than there was before workouts. In HIIT group, we witnessed a significant reduction in level of Chemerin (p=0.016) than before. CRP level was also decreased in both groups, but the changes were not significant.
Conclusion: In summary, 8 weeks of HIIT exercises compared to endurance trainings have greater effect on Chemerin and CRP levels in obese children.
Ehsan Bakhshi, Reza Kalantari, Nooshin Salimi,
Volume 20, Issue 2 (5-2017)
Abstract
Abstract
Background: Evaluation of performance is one of the hardest aspects of management responsibilities. Today, performance evaluation process is a characteristic of work world that can be useful in making workforce more effective. This study aimed to assess the job performance and its determinants in healthcare workers.
Materials and Methods: This cross sectional and descriptive –analytical study conducted in capitation way on all workers in healthcare centers and health houses of Islamabad-e Gharb city in 2016. Data collection tools were questionnaires of demographics and job performance of Hersey and Goldsmith. Descriptive statistics, one way ANOVA and Independent sample T-test used in order to data analysis.
Results: The mean and standard deviation of job performance score was 52.5± 9. There was a significant relationship between job performance with sex and education level (p<0.05). Also, there were significant relationships between feedback and environment with sex, and support aspect with type of employment (p<0.05).
Conclusion: Success and progress of each organization is based on high levels of job performance in its employees. Solutions such increasing salary and providing good physical environment, can be useful to improve job performance of employees.
Zahra Salimi , Lotfollah Khajehpour , Farshad Moradpour , Ahmad Ali Moazedi , Ali Pourmotabbed ,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: Nilutamide is a pure non-steroidal antiandrogen that is used in the treatment of advanced-stage (metastatic) prostate cancer and acts as a potent and selective antagonist of the androgen receptors. Previous studies showed that there must be relationship between androgen receptors and cognitive aspects of the brain. Therefore, it seems that nilutamide affects spatial learning and memory through effect on androgen receptors. The aim of this study is to evaluate the effect of nilutamide on spatial localization in the Morris Water Maze and synaptic plasticity at the hippocampus CA1 area of male adolescent rats.
Materials and Methods: In this experimental study, male Wistar rats were randomly divided into 4 groups (n=9). Experimantal groups received vehicle (DMSO 10%) as control groups and different doses of Nilutamide (5, 10 and 15µg/2.5µl). Drug and vehicle were injected for 4 days before training.
Ethical Considerations: This study with research ethics code
EE/ 97, 24, 3061300/ scu.ac.ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz.
Findings: Analysis showed that escape latency and traveled distance for finding hidden platform in the group which received nilutamide (15µg) were significantly lower than of control group at first (p < 0.05) and second (p < 0.01) training days. The results of field potential recording showed that nilutamide had not any significant effect on fEPSP and PS.
Conclusion: The results of peresent study releaved that i.c.v microinjection of nilutamide improved spatial learninig in first and second days, wherease increase of treatment (4 days) not affected spatial learning.
Yalda Mirmoeini, Hamid Sarlak, Shima Normohammadi, Afrooz Nakhostin, Zohreh Salimi,
Volume 23, Issue 2 (June & July 2020)
Abstract
Background and Aim: Parental acceptance is an important parameter in selecting the proper behavior management technique during pediatric dental treatment. The present study aimed to compare the effects of different informing methods on acceptance of parents about behavior management techniques used in pediatric dentistry.
Methods & Materials: This quasi-experimental study was conducted on one 162 parents of 3-7-year-old uncooperative children who were candidates for dental treatment. They were randomly divided into three groups. Their acceptance about six behavior management techniques including general anesthesia, voice control, hand-over-mouth, parental separation, active and passive physical restraint were assessed by a questionnaire. After determining the level of acceptance, the information about the techniques was presented through three ways include writing, verbal and visual methods. Finally, their acceptance of each technique and the reasons for non-acceptance were re-evaluated. Data were analyzed in SPSS v.23 software using ANOVA and t-test.
Ethical Considerations: This study obtained its ethical approval from the Research Ethics Committee of Arak University of Medical Sciences under code: IR.ARAKMU.REC.1398.102.
Results: The informing methods significantly increased the parents’ acceptance about behavior management techniques. According to the ANOVA results, the effect of visual presentation method in general anesthesia technique was significantly lower than that of other methods (P<0.05), while its effect in active physical restraint technique was significantly greater than that of other methods (P<0.05). There was no statistically significant difference between the effects of informing methods in other behavior management techniques.
Conclusion: Informing parents about pediatric behavior management techniques increase their acceptance. Informing by visual presentation is the most effective method for increasing their acceptance of physical restraint technique, while in their acceptance of general anesthesia technique other informing methods are more effective
Kurosh Farhadtoski, Mojtaba Bayani, Hamid Sarlak, Zohreh Salimi,
Volume 23, Issue 2 (June & July 2020)
Abstract
Background and Aim: Chronic periodontitis is the most prevalent form of periodontitis and it generally considered as a progressive inflammatory disease. Environmental and systemic factors can alter the immune response to biofilm and lead to progressive degenerative disease. Chronic periodontitis is defined as an infectious disease that causes inflammation in the tooth-supporting tissues, periodontal attachment loss, and bone loss. Identification of risk factors for this disease is important. Hence, this study aims to evaluate the risk factors for chronic periodontitis.
Methods & Materials: This case-control study was conducted on 120 periodontitis patients and 120 healthy controls in Arak, Iran. A questionnaire was used to estimate their Socio-Economic Status (SES) and survey demographic and risk factors. For the diagnosis of chronic periodontitis, the identification of plaque accumulation site and clinical examination were performed. To investigate the association of chronic periodontitis with study variables, multilevel logistic regression analysis was used in STATA V. 11 software.
Ethical Considerations: This study obtained its ethical approval from the Research Ethics Committee of Arak University of Medical Sciences under code: 1397.145.
Results: The Odds Ratio (OR) of chronic periodontitis in adults aged above 30 years was 2.91 (95% CI: 1.01-8.73). Compared to subjects with low SES, the OR of chronic periodontitis was 2.28 (95% CI: 1.22- 4.27) in those with moderate SES and 0.89 (95% CI: 0.79-0.98) in those with high SES. Compared to patients who did not brush their teeth, the OR of chronic periodontitis was 0.67 (95% CI: 0.39-0.89) in patients reported toothbrushing. Compared to those who reported changing toothbrush sooner than 3 months, the OR was 4.96 (95% CI: 2.27-11.3) in those their changed their toothbrush for more than 6 months interval. The OR of chronic periodontitis in current smokers was 3.09 (95% CI: 1.52-4.76).
Conclusion: Cigarette smoking, alcohol consumption, tooth brushing, and SES are the risk factors associated with chronic periodontitis.
Andia Seyedi Moghaddam, Mahdieh Salimi, Najmeh Ranji, Hossein Mozdarani,
Volume 25, Issue 1 (April & May- 2022)
Abstract
Background and Aim MicroRNAs (miRNAs) are a class of small non-coding RNAs (17-25 nucleotides) that have been studied in many diseases. miRNAs studies in different cancers have shown that miRNAs may be considered oncogene or tumor suppressor. So far, many studies have shown that miR-17-5p and miR-93-5p are important regulatory molecules in some biological processes, such as cell proliferation, associated with cancer formation. This study aimed to investigate and compare the tissue and plasma expression levels of miR-17-5p and miR-93-5p in patients with ductal carcinoma breast cancer with the normal control group.
Methods & Materials The total RNA (including miRNA) was extracted from breast and plasma tissue samples of cancerous and normal samples. The RNA concentration and purity were confirmed using optical absorbance measurements. cDNA was synthesized, and the expression levels of miR-17-5p and miR-93-5p were assessed semi-quantitatively by SYBR Green-based real-time RT-PCR assay in plasma and breast tissues of ductal carcinoma breast cancer compared with the control normal samples with SNORD47 as internal normalizer. Data were statistically evaluated using GraphPad Prism 8.0.2.
Ethical Considerations This study was approved by the Ethics Committee of the institute (IRAN 52d/4922, 6.10.2016). All study individuals signed a consent form to use their clinical samples and personal data under the physician’s supervision.
Results The expression level of miR-17-5p showed significantly higher expression in tissues and plasma of the cancer group compared with the control group (P<0.0001). It was also significantly associated with tumor stage and lymph node, and ER (estrogen receptor) and PR (progesterone receptor) status (P<0.0001). While decreased expression of miR-93-5p in plasma and tumor tissues was shown to be significantly associated with tumor stage and lymph node involvement (P<0.0001).
Conclusion The data revealed that high expression of miR-17-5p and low expression of miR-93-5p in both plasma and breast tumor might be associated with poor prognosis in breast cancer. However, miR-17-5p, due to the greater change in expression and ease of plasma detection, may serve as a possible non-invasive biomarker for breast cancer’s poor prognosis. Further follow-up studies are required to confirm this finding.
Faezeh Ezati, Ehsan Bakhshi, Elaheh Ezati, Nooshin Salimi,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and Aim Oral and dental health plays an important role in people's general health and is affected by various factors such as knowledge and attitude of a person regarding oral and dental health. Improving people's Knowledge and attitude in this regard will lead to more attention towards oral and dental health. therefore, the present study was conducted to determine the rate of tooth decay and its relationship with knowledge, attitude and performance in high school students in the Islamabad-e-Gharb city.
Methods & Materials This study was a cross-sectional study conducted among 348 high school students in Islamabad-e-Gharb. Which were selected through sampling in two stages, cluster and random. Data were collected using clinical examination and standard questionnaire and analyzed using descriptive statistics, independent t-test, one-way analysis of variance, Sheffe post hoc test and Spearman's correlation coefficient at a significance level of less than 0.05 using SPSS software, version 22.
Ethical Considerations This study was approved by the Ethics Committee of the Kermanshah University of Medical Sciences (Code: IR.KUMS.REC.1397.548).
Results The Mean Decay-Missing-Filled Teeth (DMFT) index 6.07±3.47 and Mean teeth decayed were 5.31± 2.90 respectively and 96.3 percent of the students had dental carries. Both DMFT index (r=-0.124, P=0.021) and teeth decay (r=-131, P=0.015) had a significant relationship with students' performance regarding oral and dental health. There was no significant difference between DMFT index and the number of teeth decayed with students' knowledge and attitude regarding oral and dental health (P<0.05). No significant relationship were found between either DMFT index (P=0.749) and teeth decay (P=0.614) with gender.
Conclusion In this study, DMFT index and teeth decay were relatively high and this shows the need to design educational interventions in adolescents to prevent teeth decay.
Zohreh Salimi, Hamid Sarlak, Mojtaba Bayani,
Volume 28, Issue 1 (3-2025)
Abstract
Introduction: Pain of anesthesia injection in children is necessary and one of the most painful local anesthetics is palatal infiltration anesthesia. So, the purpose of this study was to compare the effect of needle gauge on pain and anxiety during palatal infiltration anesthesia injection in children 4-8 years.
Methods: This triple-blind cross-over clinical trial study was performed on 60 children 4-8 years candidates for pulpotomy and SSC treatment of both maxillary first molar teeth. Based on the sequence of using 27- and 30-gauge needles, children were treated during 2 sessions. The anxiety level of children during palatal infiltration local anesthesia was measured using pulse rate (PR) and the pain level of patients was measured using SEM and FPR (objective and subjective criteria).
Results: Anxiety during palatal anesthesia injection with gauge 27 was higher than gauge 30 (treatment effect < 0.001). In subjective and objective criteria, the injection pain in the palatal mucosa with a 27-gauge needle was higher than 30-gauge needle (treatment effect < 0.001). There was no significant difference between earlier and later injection of palatal infiltration with different gauges during treatment sessions (P < 0.05) and according to 0.021 for the period effect, it can be said that the period of receiving two needle gauges had an effect on the average heart rate difference.
Conclusions: The pain of injection in the palatal mucosa with a 27-gauge needle is higher than with a 30-gauge needle, and the use of a 30-gauge needle in the palatal injection of children 4-8 years causes less discomfort than a 27-gauge needle.
