Showing 10 results for Safari
Mahmood Reza Baghinia, Abolfazl Safari, Afsaneh Akhondzadeh, Mahmood Ebrahimi,
Volume 8, Issue 1 (Spring 2005)
Abstract
Shirin Iran Far, Taravat Fakheri, Firozeh Safari, Shirin Amir Fakhri, Mansour Rezaie,
Volume 8, Issue 2 (7-2005)
Abstract
Introduction: Considering the importance of diagnosing fetal distress and knowing diagnostic methods with minimum cost and time and high diagnostic value, this study was performed to evaluate the vibroacoustic stimulation test ( VAST) value in predicting fetal distress in women in active phase of labor, reffering to Motazedi hospital, Kermanshah, 2004.
Materials and Methods: This clinical trial study was carried out on women in active phase of labor (dilatation >3-4), full term, single fetus, cephalic presentation, without previous diseases and also abnormal fetus. At first FHR was monitored for 15 minutes, then vibroacoustic stimulation was done for 3 seconds using an artificial larynx of Seimens Servox with high - pitch intensity equal to 105 dB. Results were recorded as non reactive and reactive FHR ( twice 15 beats acceleration for 15 seconds). Other variables such as type of delivery, 1 and 5 minutes Apgar, meconium passing and nuch cord were documented. Data was analyzed by descriptive statistics and diagnostic value test.
Results: Age of women was 25.2 ±5.8, number of pregnancy 1.94 ± 1.33 and 51.8% of them had one pregnancy. FHR before VAST was 61.1% reactive and 26.3% suspicious and after VAST 60.8% reactive and 5.3% suspicious. In VAST method sensitivity, specificity and diagnostic value were 88.3%, 70% and 75.5% respectively and in nonVAST method 68.3%, 66.5%, 23.6%.
Conclusion: This study showed that VAST can assist to reduce suspicious cases of FHR.The prognostic value of VAST in predicting fetal distress was high. It is recommended to carry out further researches about duration and intensity of sound and using periodic FHR
Salman Ahmady Asbchin1, Moein Safari, Hosein Moradi, Vahid Sayadi,
Volume 16, Issue 6 (9-2013)
Abstract
Background: The most important pathogen in nosocomial infections are microorganisms in the patient's body. 90 percent of nosocomial infections caused by bacteria. Medlar is an medicinal plant that its therapeutic effects has historically been emphasized. The aim of this study was to evaluate the antibacterial effect of methanolic and ethanolic leaf extract of medlar against bacteria isolated from hospital environment.
Materials and Methods: In this experimental study, the Nosocomial bacteria were obtained from Shahid Mostafa Khomeini hospital, Ilam, Iran. Soxhlet extraction method was used for medlar leaf extract. Disk diffusion method was used to study the effect of antimicrobial and broth microdilution method were used to determine the minimum inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC).
Results: Two strains of Pseudomonas aeruginosa, three strain of Staphylococcus aureus and five strains of Escherichia coli were isolated from hospital. The results showed that the methanolic extract of Medlar leaf inhibited the growth of all strains of pseudomonas aeruginosa and four strain of Staphylococcus aureus and also inhibits the growth of all strains of Escherichia coli strains except E4 strain. The maximum antimicrobial activity was against E2 strain that zone diameter around it was 19/67 Millimeters. Quantities of minimum inhibitory concentration for all three strains P1, P2 and P3 and E2, E3, E5, S1, S2 and S3 strains was equals with 125 mg/ml.
Conclusion: Medlar leaf methanolic extract possesses significant antibacterial activity against bacteria causing nosocomial infections and so this extract can be considered in the control of infectious diseases.
Farzad Ebrahimzadeh, Ebrahim Hajizadeh, Abdolkarim Shadmehr, Nasim Vahabi, Ezatollah Fazeli Moghadam, Javad Nasseryan, Mehdi Safari,
Volume 18, Issue 10 (1-2016)
Abstract
Background: Height and weight growth failure are among the most important health disorders affecting children less than two in the developing countries. Failure to treat this disorder can lead to the development of serious conditions including increased mortality and types of disability. The aim of the present study is to investigate the factors affecting the height and weight growth of children less than two years old.
Materials and Methods: This historical cohort study was conducted on a sample of 2030 children less than two in Khorramabad who were selected using stratified and cluster sampling methods. Based on household records, data related to the height and weight were recorded as quantitative variables and finally were modeled using a longitudinal marginal model, identity link functions and the R software.
Results: Based on the marginal model, the effect of such variables as child's age, child's gender and mother's educational attainment were significantly related to the child's height and weight. Moreover the child's birth order had significant relationship with only the child's height. However, the variable of exclusive breastfeeding during the first six months was no significantly related to weight and height growth of the children.
Conclusion: Given the results, it seems that monitoring the growth of the children of the illiterate mothers, specially the girls and the children with first birth orders are the most important approaches to deal with growth disorders among this population.
Mohabbat Jamhiri, Zeinab Hafizibarjin, Mojtaba Ghobadi, Ali Moradi, Fatemeh Safari,
Volume 20, Issue 4 (7-2017)
Abstract
Abstract
Background: Oxidative stress plays an important role in the pathogenesis of hypertension- induced cardiac hypertrophy. Plants are a rich source of antioxidant compounds. Thymol is a natural monoterpen phenol which is plentiful in some plants and shows many biological effects. The aim of the present study was to assess the effects of thymol on activity of antioxidant enzyme catalase, malondialdehyde (MDA) level and the activity of the inhibition of free radical DPPH (2,2-Diphenyl-1-picryl-hydrazyl), following left ventricular hypertrophy in rats.
Materials and Methods: In this experimental study, rats were divided into hypertrophied group without any treatment (H group) and rats pretreated with 25 and 50 mg/kg/day of thymol (Thy25+H and Thy50+H groups, respectively). Intact animals were served as control (Ctl). Animal model of left ventricular hypertrophy was induced by abdominal aortic banding. Serum catalase (CAT) activity, malondialdehyde (MDA) level and the activity of inhibition of free radicals DPPH were determined by the biochemical methods.
Results: In Thy25+H and Thy50+H groups, the CAT activity was increased significantly in serum (p<0.01, vs. Ctl). Also, serum level of MDA was decreased significantly compared to the group H in Thy25+H and Thy50+H groups (p<0.05 and p<0.001, respectively). The effect of inhibiting DPPH free radicals was increased significantly in Thy25+H and Thy50+H groups compared to the group H (p<0.001 and p<0.05, respectively).
Conclusion: The findings of this study suggest that thymol as an antioxidant causes cardioprotective effects and as well as prevents left ventricular hypertrophy via augmentation of serum antioxidant capacity.
Mohsen Dalvandi, Hyder Farahani, Ramin Safari Rad,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Low Back Pain is one of the most common complains of Human societies. LDH (Lumber Disk Herniation) is one of the relatively common causes of Low Back Pain. This study aimed to assay serum zinc cofactor in patients compared to healthy group.
Materials and Methods: Sixty patients which were diagnosed as a "known case of LDH" by the specialist and based on tests were chosen by simple selection method (30 men and 30 women). Also, 57 people were chosen as a control group (29 men and 28 women). measurement was done based on single reagent direct calorimetric method using the kit made by "Ziestchem diagnostics company, Iran".
Findings: Total, 117 objects were observed in case and control groups. Serum zinc level was measured in all of them. Obtained results were analyzed by Student t-test, and ꭕ2, by using SPSS software with the confidence interval of 95 percent. Results showed that 21.7% of patients with LDH were having high physical activity and 36.7% having low physical activity.
Conclusion: There was a significant difference between the mean serum zinc levels in patients with LDH compared to control group. Decrement in serum zinc may be considered as an distruption factor in the activity of enzymes involved in proteins biosynthesis.
Nasim Karimi, Maliheh Safari, Ghodratollah Roshanaei, Jalal Poorolajal,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Acquired immunodeficiency syndrome is caused by body contamination with human immunodeficiency virus. Several factors affect the survival of people with AIDS, which are often examined using Cox regression models. The default is to use the Cox model as a proportionate hazard, which in case of a violation, this model does not have the required performance. Therefore, the aim of this study was to determine the effective factors on survival of AIDS patients using the developed Cox model.
Materials and Methods: In this cohort study, 1050 patients with AIDS who referred to Imam Khomeini and Zamzam Behavioral Counseling Centers in Tehran Province during the years 2004 to 2014 were studied. The effect of clinical and demographic factors on survival of patients has been investigated using extended Cox model.
Findings: 79% of patients were men. The mean age of the patients was 34.84 ± 10. 21 years old. The mean of the diagnosis time to AIDS was 23.64 ± 15.53 months. 76% of patients were cencored. Age at diagnosis, transmission modes, ART, CD4 count, and time to diagnosis of AIDS in univariate and multivariate analysis were significant
(p <0.05).
Conclusion: Several clinical factors have implications for the survival of AIDS patients. The most important of these factors is the use of ART and early detection of the disease, which greatly increases the chance of survival of the affected population. Therefore, it seems necessary to provide screening and treatment services for high-risk individuals.
Azadeh Safari, Mehdi Moradi, Mojtaba Khansooz,
Volume 23, Issue 2 (June & July 2020)
Abstract
Background and Aim: The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and the consumption of kefir dough on anthropometric indices, plasma lipid profile and blood pressure in overweight non-athletic women.
Methods & Materials: This quasi-experimental study was performed on 32 non-athletic women with overweight in Arak, Iran (mean age= 33.94±8.58 years, mean height= 1.59±0.05 cm, mean weight= 70.15±6.88 kg, and body mass index= 27.35±1.50 kg/m2) who were voluntarily selected and randomly divided into four groups of 8 (control, exercise, exercise + supplement, and supplement). The control group had a normal diet without exercise; the supplement group received 100 ml kefir dough three meals a day for 8 weeks; the exercise group performed aerobic exercise for 8 weeks, 3 sessions per week, each for 50 minutes. The exercise + supplement group received both aerobic exercise and kefir dough. Blood and anthropometric variables were measured at the beginning and at the end of the intervention. Paired t-test was used to examine the within-group variations and one-way ANOVA to examine the between-group variations. All statistical tests were performed at the significant level of P<0.05.
Ethical Considerations: This study has obtained its ethical approval from the Research Ethics Committee of Qom University (Code: IR.QOM.REC.1398.01).
Results: The combination of kefir dough supplementation and aerobic exercise significantly reduced the mean blood pressure (P=0.003) and BMI (P=0.03) but had no significant effect on total cholesterol (P=0.27), triglycerides (P=0.61), high-density lipoprotein (P=0.16), low-density lipoprotein (P=0.30) and waist-to-hip ratio (P=0.24).
Conclusion: Overweight women can benefit from the aerobic exercise combined with kefir dough supplementation to reduce their blood pressure and BMI. Further studies are recommended to determine the effect of aerobic exercise and kefir supplementation on serum total cholesterol, triglyceride, low- and high-density lipoproteins, and waist-to-hip ratio.
Fatemeh Sharafi Bajgan, Reza Safari, Maryam Nejat Dehkordi,
Volume 24, Issue 4 (October & November 2021)
Abstract
Background and Aim: Tamoxifen is a group of drugs of selective estrogen receptor modulators, and is one of the drugs effective in the prevention and treatment of some cancers (such as breast cancer). In this study, the interaction of tamoxifen with DNA is investigated experimentally. Also, the electronic structure (at atomic scale) of the molecular system of tamoxifen was theoretically investigated, using atom in molecule (AIM) theory.
Methods & Materials: First, in the experimental section of this study, the interaction of Tamoxifen with DNA were investigated by UV-ViS technique and hydrodynamic method (Viscometry). In addition, the analysis of the experimental results shows the obvious effect of concentration on the mechanism of how the tamoxifen molecule binds to DNA. Then, in the theoretical part of this research, using computational biophysical chemistry methods, some properties of tamoxifen molecular system, such as electronic Density of States (DOS), boundary orbital’s energy (HOMO/LUMO), Electrostatic Potential Energy (EPS) and electronic contour maps of the electron density and its Laplacian, will be calculated.
Ethical Considerations: This article is a meta-analysis with animal sample.
Results: Result of the UV-ViS spectroscopy technique and viscometry indicated hyperchromism and hypochromism effect. In addition, the result were depend on the concentration of the drug and affected the kind of binding of Tamoxifen to DNA. the analysis of computational studies on the drug tamoxifen suggests that the mechanism of the local charge/energy distribution in the molecular system of tamoxifen plays an important role in how this drug binds to DNA.
Conclusion: Based on the experimental results of UV-ViS technique and viscometry, as well as the electronic/vibrational properties of the tamoxifen molecular system, it was defined that the Tamoxifen interacts significantly with all the binding sites of DNA.
Dr Mehdi Asghari, Dr Gholamabbas Fallah Ghalhari, Dr Marzieh Abbasinia, Dr Farbod Ebadifard Azar, Dr Fahimeh Shakeri, Dr Mohammad Javad Ghanadzade, Mr Gholam Heidar Teimori, Dr Sanaz Karpasand, Dr Hossein Safari,
Volume 26, Issue 3 (August & September 2023)
Abstract
Introduction: One of the biggest environmental challenges of the 21st century is the phenomenon of climate change and global warming, which can cause numerous health problems. One significant health issue associated with climate change is the increase in the prevalence of heat stress, particularly in occupational encounters in hot outdoor environments. So this study aimed to predict and model temperature and humidity indices in the coming decades in a dry climate.
Methods: This study obtained daily atmospheric parameters, including minimum temperature, maximum temperature, and relative humidity of Kerman station, representing a dry climate, for a period of 30 years (1965 to 2005) from the meteorological organization. Modeling of these parameters and calculation of the Temperature and Humidity Index (THI) were performed using the atmospheric general circulation model HadGEM2-ES and the CORDEX dynamic microscaler model. Three different radiative forcing scenarios, including optimistic (RCP 2.6), intermediate (RCP 4.5), and pessimistic (RCP 8.5), were considered for the coming decades (three 30-year periods from 2011 to 2099). The Ethics Committe of Iran University of Medical Sciences (IUMS) approved the present study (Code: IR.IUMS.REC.1400.020).
Results: The results of the study showed an increasing trend for minimum and maximum temperature parameters in all three time periods using the three scenarios considered. Moreover, the increase in temperature in the decades of 2099-2071 was more pronounced compared to the previous decades. The results also demonstrated an increasing trend in the THI index based on all three scenarios. The average results obtained using these scenarios showed an increase of 2.11, 2.53, and 3.3 degrees Celsius, respectively, in this index until the end of the last century compared to the base decades.
Conclusions: Overall, the increase in temperature and the investigated THI index in the studied station, based on all three scenarios, will lead to changes in thermal comfort. Higher levels of thermal discomfort will not only occur in hot months and seasons but also in other seasons. Therefore, proper planning should be implemented to address the adverse effects of climate change on people's health.
