Showing 9 results for Sadrnia
Vahid Goharian, Mohammad Sadegh Rajaei, Saeid Sadrnia,
Volume 2, Issue 7 (Summer 1999)
Abstract
The aim of this study is to determining the prevalence of cigarette smoking and the causes of initiation in boy students of medical science in Arak university. Declining of smoking depends to recognizing risk factors specially in young age group and the results of this study use to evaluate the plans. This descriptive study was done with convenience sampling and studied all boy medical students in Arak university with self-administered questionaires in 77-78 curiculum. This survey instrument contained age, course of study, passed semesters, smoking bahaviour family history, praying and living site .The smoker also answered to question about time of initiation, mean of cost family information and the number who giving up the habit of smikong. 98.7% (n=475) of students with mean of age 23.06 years answered to question 34.3% had smoking bahaviour. The prevalence of smoking was the lowest among those who were married and negative family history. The prevalence of smoking in students who prayed was 1.4 of others. The most common cause of initiation were being resident with friends, stress life and initiation. Lowering we must improve the "NAMAZ" task and marriage accompaniment with lowering stress life and teaching for friend selecting and determining a suitable pattern for students in Arak university.
Saiid Sadrnia, Ali Chehreii,
Volume 9, Issue 3 (9-2006)
Abstract
Introduction: Hypertension is a common asymptomatic and usually easy to treat disease. Regarding the fact that genetic, social and nutritional factors responsible for inducing hypertension are not the same in different societies, it is necessary to performe a study to introduce a model of hypertention which includes laboratory measures as risk factors of hypertension at Arak city in 2004. Materials and Methods: This is a case-control study. Study samples were 1000 persons (263 patients with hypertension and 737 healthy people). Samples were selected using multi-stage method in which the population ratio in city and village in both groups was considered. Laboratory findings and ECG results were documented. Data was analyzed using descriptive statistics and logestic regression. Results: In this study hepertensive patients were compared to healthy people. Some risk factors in this study were LVH (p<0.0001), high triglyceride, hypercholesterolemia and hyperglycemia. Also a model was made based on ECG results and laboratory findings to predict the probability of hypertension. Conclusion: By educating physicians about the determined risk factors in this study, they can control them better and decrease hypertension complications in heart, brain, kidney and eye. On the other hand the obtained model can be used in determination of the propable hypertension in people with positive family history
Saeid Sadrnia, Ali Chehrei,
Volume 11, Issue 1 (3-2008)
Abstract
Introduction: Left ventriculor hypertrephy (LVH) is one of the complicotions of systemic hypertension. LVH increases probabiltis of cardiac arrhytmia and cardiovasculer event in hypertensive patiants. In addition to hypertension other factors such as dyslipidemia, hyperglicemia and renal failure can cause LVH. This study was designed to investigate the effects of Body Mass Index (BMI) and some laboratory factors on LVH. Materials and Methods: This is a case-control study in which patients in case group (hypertensive patients with LVH) and patients in control group (hypertensive patients without LVH) were compared for BMI, dyslipidemia, hyperglycemia, and elevated Blood Urea Nitrogen (BUN) and Creatinin. Data was analyzed using Chi square test and logistic regression. Results: BMI with, high blood glucose with, high BUN and Creatinin signiticant affect in LVH presentation in hypertensive patiants. Dyslipidemia had not signiticant affect. Conclusion: In this study BMI, hyperglicemia, high BUN and Creatinin affected LVH presention in hypertensive patiant. So it is recommended that these factors be carfuly monitored and and treated.
Reza Shahmirzaei, Saeed Sadrnia, Hassan Solhi, Ali Ghasemi,
Volume 13, Issue 2 (6-2010)
Abstract
Background: Positive electrocardiogram (ECG) changes in patients with unstable angina or non-ST elevation myocardial infarction are well known, but problem arises when no specific changes in ECG are identified. The aim of this study is to evaluate the prevalence of these changes in hospitalized patients at Amir Kabir Hospital of Arak. Materials and Methods: This study was a cross-sectional one that was conducted on 124 patients hospitalized at the heart emergency ward of Arak Amir Kabir Hospital with unstable angina and non-ST elevation myocardial infarction. ECG changes and serum cardiac enzyme levels were analyzed on admission and 12 hours after admission. Results: According to patients’ history and serum cardiac enzymes, 62 patients had undergone myocardial infarction without ST segment elevation, 98.4% of whom had ECG changes and 1.5% showed no ECG changes. Of the 60 patients, who had been hospitalized with unstable angina, 90% showed ECG changes and the rest 10% revealed no such changes. Conclusion: In comparison to other studies reporting that 50% of patients with unstable angina and non ST elevation myocardial infarction reveal no ECG changes, a high percentage of patients referring with a chest pain to the heart emergency ward of Amir Kabir Hospital, had no significant changes in their ECG and were not hospitalized.
Saeid Sadrnia,
Volume 15, Issue 4 (September 2012)
Abstract
Background: Left main coronary artery divides into left anterior descending and circumflex arteries. Total occlusion of the left main coronary artery without extensive MI and cardiogenic shock is a rare finding. Case: The patient is a 50-year-old man that had referred to doctor’s office with history of exert ional chest pain two months earlier. Although he did not have history of rest angina, he had history of smoking as well as positive family history for coronary artery diseases. Exercise test with echocardiography revealed significant S-T depression. Hence, coronary angiography was done for the patient which showed total occlusion of the left main and originated left circumflex artery from right coronary artery and left anterior obliq filled from right coronary artery. The patient was candidate for coronary artery bypass graft. Conclusion: Total occlusion of the left main coronary artery without cardiogenic shock and death is a rare finding. This phenomenon occurs when occlusion is chronic and it is followed by right coronary artery with well-developed collateral which might be presented with stable angina. The mainstay treatment for total occlusion of the left main coronary artery is coronary artery bypass graft
Maryam Sadrnia, Mohammad Arjomandzadegan,
Volume 17, Issue 6 (9-2014)
Abstract
Background: Nowadays, with the development of drug resistance, the use of herbs as an alternative to chemical drugs is considered by researchers. In this work, effects of Aloe vera extracts on clinical isolates was studied.
Materials and Methods: Aloe vera plant medicinal plants were obtained from a greenhouse. Three extracts including essential oils, extracts and no essential oils and essential oil extraction method also includes a complete extract of Aloe vera were prepared Percolation total. To investigate Microbiology extracts of two strains of Staphylococcus aureus and Staphylococcus epidermidis clinical strain of Gram-positive and Gram-negative isolates of Klebsiella pneumoniae and Escherichia coli strains Staphylococcus aureus ATCC25923 were used as well. Evaluate the effect of two methods: Kirby-Bauer disk with the minimum inhibitory concentration (MIC) was performed using microplate dilution. Turbidity was determined by an ELISA reader apparatus.
Results: All extracts of aloe vera on Klebsiella with a diameter of 32±2 mm mg/ml 285.7 concentration with microplate dilution method was 2.23 mg/ml. Staphylococcus aureus and MIC zone diameter of 30±2 mm and mg/ml 2.23, Staphylococcus epidermidis and Escherichia coli mg/ml4.46 mm 17.85 mm 30±5 mg/ml 17.85 respectively. Similar concentration of 17.85 mg ml Aloe Vera with a circle formed by the disk mc/ml 10 gentamicin was shown. This effect is similar to other bacteria antibiotics gentamicin, clindamycin, erythromycin, and Cefixime compared with Aloe Vera extract has been proven. Essential oils made from all parts of the same whole extract of aloe vera, but not essential extracts, bacteria studied were ineffective.
Conclusion: In this study the effects of similarity and some excess water Asrsarh Aloe Vera with common antibiotics on bacteria causing the infection was confirmed. Therefore, by production of appropriate pharmaceutical plant drugs with fewer side effects, bacterial infections couled be treated properly.
Maryam Sadrnia,
Volume 21, Issue 1 (4-2018)
Abstract
Abstract
Background: Aflatoxins are natural fungal toxins produced by Aspergillus species such as A. flavus. The toxins are poisoning and can cause tissue necrosis and liver cancer. The aim of this study was to determine the control of Aflatoxin B1 production by extracts and essential oils.
Materials and Methods: Aqueous extracts were prepared by heating and essential oil by Clevenger's apparatus. Antifungal activity of essential oil and aqueous extract of Mentha pulegium and Satureja hortensis were determined by disc diffusion and microplate dilution methods. Production control of Aflatoxin B1 was investigated with concentrations under MIC(Minimum inhibitory growth concentration) of two materials and were determined by HPLC method.
Results: The most zone of inhibition was 10% belonging to Satureja essential oil and its aqueous extracts with diameters of 26mm and 12mm, respectively. These values for Mentha extract and 10% essential oil were 18mm and 8mm respectively. MIC of the aqueous extract of Satureja and Mentha were 0.031 and 0.063mg/ml respectively, and 1% essential oil of two materials was 0.039 and 0.078 mg/ml, respectively. Aflatoxin B1 produced by A. flavus in concentrations of 1%, 2% and 10% Satureja essential oil were 122, 113 and 134 ppb, in 1%, 2% and 10% Mentha were 163, 168 and 171 ppb, respectively. The aqueous extracts of 1% Satureja reduced the production of toxin as 58.1 and the 1% aqueous extract of Mentha as 39.6.
Conclusion: The results of this study showed that both Satureja hortensis and Mentha pulegium have the ability to inhibit the growth of Aspergillus flavus fungus, as well as control of aflatoxin B1 production in low concentrations and recommended for further studies.
Maryam Sadrnia, Ghasem Habibi, Mohammad Arjomandzadegan,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: In this study, the effect of Myrtus extracts on 25 methicillin resistant Staphylococcus aureus (MRSA) and Escherichia coli ESBL strains isolated from patients were compared by two methods.
Materials and Methods: 15 methicillin-resistant Staphylococcus aureus (MRSA) and 10 Escherichia coli ESBL isolates were used in this study. Fresh Leaves of Myrtus were collected from the herbal medicine farm. Extraction was performed using a reflux distillation. The effect of concentrations 0.195-100 micrograms per ml of Myrtus extract on clinical isolates was analyzed in disk diffusion method compared with micro broth dilution method and with MTT in 545 nm on an ELISA reader apparatus.
Findings: Inhibition zone diameter for the minimum effective concentration of 50 micrograms per milliliter in all isolates of ESBL and MRSA were as 8±1 mm and 11±1. Minimum Inhibitory Concentration (MIC) was 6.25mic/ml and Minimum Bactericidal Concentration (MBC) was determined 12.5mic/ml for E. coli ESBL. Furthermore, the amounts for MIC and MBC was determined as 12.5 and 25 mic/ml, respectively for Staphylococcus aureus.
Conclusion: The results of this study showed compliance of two methods in evaluation of drug-resistant clinical isolates. It was proved that the disk diffusion method could be determining range of effective concentration but micro broth method determines the effective concentration carefully. It is recommended that results obtained from disk diffusion not to be basis for final decisions in traditional medicine studies. Bacterial behavior in the broth and determination of the point of death greatly increases the accuracy of the results.
Ahmad Sahabzamani, Dr. Maryam Sadrnia, Dr. Majid Akbari, Dr. Sasan Saki,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and Aim The efflux pump in Pseudomonas aeruginosa inhibits the effect of ciprofloxacin by releasing quinolones out of the cell. It is important to find compounds to inactivate or inhibit its activity to continue using the antibiotics. The present study was done to investigate using sertraline as an efflux pump inhibitor in P. aeruginosa to reduce antibiotic resistance.
Methods & Materials P. aeruginosa strains were isolated from clinical sources and identified by routine microbiological methods. Resistance of the isolates to ciprofloxacin was evaluated by Kirby–Bauer test. Resistance breakdown was investigated by adding sertraline to the Moller Hinton agar medium and determining the zone of inhibition of ciprofloxacin. Minimum inhibitory concentration (MIC) by microplate dilution method and Minimum bactericidal concentration (MBC) by culture and MTT method were done for the isolates and ATCC 27853. The presence of the efflux pump was evaluated by the phenotypic method using sertraline and serial dilution method of the liquid medium in a microplate, on ciprofloxacin-resistant strains. The presence of the producing gene of this pump was determined by the genotyping method in resistant strains by performing PCR. The standard PAO1 strain of P. aeruginosa was used as a positive control.
Ethical Considerations This study was approved by the Ethics Committee of the Faculty of Medical Sciences of Islamic Azad University, Brojerd Branch (Code: IR.IAU.B.REC.1401.011).
Results Based on Kirby–Bauer test results, three strains were considered resistant to ciprofloxacin. MIC of drug-resistant strains was between 32 and 64 mg/ml and MBC was between 16 and 32 mg/ml. By performing electrophoresis on the PCR products, it was determined that the tested strains contained the mexA gene encoding the efflux pump. In the agar medium without sertraline, the zone of inhibition around the ciprofloxacin disc was zero, but after adding sertraline, the diameter of the halo increased to 25 mm. The minimum inhibitory concentration of ciprofloxacin in the isolates before adding 25 µg of sertraline was 128 µg/ml and after adding sertraline, it was 4 µg/ml.
Conclusion It was concluded that sertraline inhibited the efficiency of the efflux pump in resistant P. aeruginosa isolates and reduced ciprofloxacin resistance.
