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Introduction: Regarding the extensive use of IUD, as contraception. The present study was conduced to evaluate the complications resulting from muliload 375 and T Cu 380A IUD inserted in women referred to the health and treatment settings of Kermanshah medical sciences university in the year 2002.
Materials and Methods: The study was descriptive-analytic, on 122 women using M.L 375 IUD and 245 others using T 380A IUD were fully assessed. The tools used to collect data were questionnaires evaluating the following variables: Pregnancy, bleeding, ectopic pregnancy, uterine perforation, and expulsion, pelvic inflammation disease (PID). To analyze the data, descriptive statistic and X², student-T and Fisher tests were used.
Results: Severe bleeding during menstrual cycle was the most common complication in the two study groups, especially in the multiload 375 IUD group (75% vs. 41.6%; P<0.001). The multiload 375 IUD had a significantly higher dysmenorrhea rate compared to the T cu 380A (%70.8 vs. %40.8; P<0.001). The rate of intera-uterine pregnancy was low for the two device %1.7 vs. %2, and occurrence of ectopic pregnancy in multiload 375 IUD was 0.8% and in T Cu 380A group was not reported. There was no uterine perforation observed for either device.
Conclusion: According to the results gained, the common complications in each group were not dangerous and their severe and threatening complications were uncommon. The most frequent complications were severe bleeding during menstrual period, dysmenorrhea and spotting which were not life threating and could be controlled by supporting and training their users, although these complications were seen more among those using M.L 375 IUD. These two device were effective enough to prevent pregnancy. It seems that using T Cu 380A IUD is more suitable for those who want to have a long-term contraception.

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Introduction: Diabetic neuropathy is a common complication of diabetes, leading to great morbidity and mortality and resulting in a huge economic burden for care of the patient with diabetes. It is the most common of neuropathy in the developed countries of the world, accounts for more hospitalizations than all the other diabetic complications combined, and is responsible for 30% 1075% of nontraumatic amputations.
Materials and Methods: This investigation is a descriptive analytic, cross-sectional study among 40 diabetic patients without symptoms of peripheral neuropathy referred to Aruk Vali-Asr diabetes clinic from March to september of 2003. Patients were referred to one neurologist for study of peroncal and tibial motor nerves and sural sensory nerve conduction velocity in electrodiagnostic clinic of Arak Amir Kabir hospital. The results of this group were compared to the results of 70 age and Gender matched normal control subjects. Independent samples T-Test, Pearson correlation coefficient and Fisher's exact test were used in analysis.
Results: A total of 40 patients were studied with mean age of 42.6 years and mean duration after the first diagnosis of diabetes 5.72 years. Mean investigated nerves conduction velocity in the normal control group was meaningful more than in diabetic patients. Asymptomatic neuropathy was present in 27 (67.5%) of patients. In these patients mean duration after the first diagnosis of diabetes was 6.5±5.16 years.
Conclusion: Asymptomatic diabetic neuropathy is common (67.5%) sural sensory. Nerve conduction velocity is a sensitive test for early diagnosis of diabetic neuropathy.

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Introduction: In developing countries there are various researchable health subjects. However due to low budjet of research programmes in these countries, priority setting of research designs have a special importance.
Materials and Methods: In a descriptive cross-sectional study, a questionnaire consisting of 100 questions was designed. 363 health personl and 302 non-health specialists participated in this study. Questionnaire was coded and analysed by EPI 6 software.
Results: Our results demonstrated that all of the cities of Markazi province had a similar problems, but the amount of people contributions in health activities has altered their health awareness. Furthermore, health problems in view of people and specialists is different. People stated health problems as a global difficulties while specialists had a detailed viewpoints.
Conclusion: This study showed that it is necessary to guide practical researches based on determined health priorities.

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Introduction: Some articles have suggested an increase in the prevalence of oral candidiasis in patients with psoriasis, as well as the potential for exacerbation or chronicity of psoriasis. Therefore, the prevalence of oral candidiasis in patients with psoriasis and its comparison with healthy individuals has been considered.
method: In this cross-sectional study, 43 people with psoriasis and 43 seemingly healthy individuals referred to dermatology clinics affiliated with Isfahan University of Medical Sciences were randomly selected and examined for the presence or absence of Candida albicans in the oral mucosa by direct lam and culture. Were placed.
Results: According to the results of this analytical study, 44.2% of patients with psoriasis with Candida albicans were infected with oral cavity, which was 25.6% for healthy individuals, and this difference was significant (p=0.05). There was also a significant relationship between the severity of psoriasis and the prevalence of oral Candida albicans (p=0.05).
Conclusion: The study found that candida yeast was more common in patients with psoriasis than in healthy people. According to the results of this study, it is recommended that all patients with psoriasis be examined for the presence of Candida albicans in the mouth and, if the test is positive, be treated with antifungal drugs.

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Background: Epileptic seizures are manifestation of epilepsy. Understanding of the mechanisms causing epileptic disorder needs careful analyses of the electroencephalograph (EEG) records. The detection of epileptic form discharges (spike wave) in the EEG is an important component in the diagnosis of epilepsy. Approximately one in every 100 persons will experience a seizure at some time in their life. Already intelligence spike detection method discucsed but purpose of this research is diagnosis of different kind of epilepsy (grandmal and Petitmal) by design of an intelligence diagnosis processing. Methods and Materials: In this descriptive study, 100 EEG signals of brain hemispheres from different person in healthy, interictal and ictal conditions were used. Fifty Hz noise and artifact signals were removed by soft ware procedure then signals separated by expert neurologist to three categories, healthy (frequency band 8-12 Hz), petitmal seizures (typical 3 Hz), grandmal seizures (clonic stage with 4 Hz frequency) and divided each of them to 6 seconds segments. Information of this signals (background alpha, spike and slow, poly spike and poly sharp) were extracted by wavelet transform and classified by soft ware procedure neural network to there groups healthy, ptitmal and grandmal epilepsy. Results: In designed software accuracy of diagnosis ptitmal and grandmal epilepsies was obtained about 80% Conclusion: This method introduced intelligent diagnosis of epilepsy (ptitmal and gradmal) and automatically detected healthy person from epileptic patients. One of the other advantages is help to neurologist for detection of sickness clearly and expendable different kinds of other epilepsy

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Background: Delay in treatment of acute myocardial infarction has an important effect on developing the myocardial damage and the prognosis of the patients. In this study, interval between the onsets of symptoms until hospitalization was studied on patients who reffered to fatemeh Zahra hospital of Bushehr port. Methods and Materials: This is a cross-sectional analytic study, carried out on 120 patients, with acute heart attack in Bushehr hospital by using a sampling during 9 month period. A questionnaire was used consisted of three sections: first demographic information second, questions about time Interval between the Beginning symptoms to hospitalization and third questions about cause of delay that it was completed by inteviwe method. Results: Results showed that the total length of time between the onset of symptoms and hospitalization EU was 273/33±259 minutes. There was significant relation between positive family history, past history of CAD, having insurance, chief complain, going to physician clinic before hospitalization and age with the delay timed (P<0.05). The most common cause of delay was lack of knowledge about symptoms and inattention toward their importance. Conclusion: Time Interval between the onsets of symptoms to hospitalization approximately was 4.5 hours that was not acceptable. Findings indicate developing educational approaches to increasing patient’s knowledge is necessary for better understanding of symptoms in the onset of MI that hereby with the delay time reduces.

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Background: There are not appropriate research about use of saline lock for obtaining blood samples and intravenous drug or fluids. The purpose of this study was compared the biochemistry values obtained by venipuncture and saline lock after intermittent administration of solution and medication. Methods and Materials: This quasi-experimental prospective study was done on 63 patients who were admitted in Cardiac ward Amir-Kabir educational hospital. The sampling method was convenience. A tourniquet was tied above the saline lock, the first 0.5 ml of blood withdrawn was discarded, then 5 ml blood was obtained. Simultaneously, 5 ml sample was drawn from the opposite arm. The samples were analyzed for FBS, Chol, TG, HDL, LDL, BUN, Cr, Na, K, CPK & LDH. Results: 53.9% participants were male. Mean of age was 63.52±12.63 years. There were no significant differences in mean of biochemistry values in blood obtained by venipunctures saline locks (p>0.06). Conclusion: Nurses can use saline lock after intermittent intravenous drugs and fluids, in order to determine blood sample for evaluating blood biochemistry value. This method relieve pain, due to blood sampling.

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Abstract Background: One of the most important effective factors on students’ learning is their learning style. This study was done to determine learning styles of students in Arak University of Medical Sciences in 2008. Materials and Methods: In a descriptive cross sectional study, 241 first semester students in Arak University of Medical Sciences were selected by census sampling method. The data gathering tool was a questionnaire containing demographic questions and Kolb's learning style questionnaire. Results: The most students learning style was assimilating (58.1%), Converging (25.31%), diverging (10.37%) and accommodating styles (6.22%) were followed. In all fields the most prevalent learning style was assimilating, too. The majority of operating room (56.2%), battle health with disease (57.9%), environment health (53.6%), nursing (43.9%), medical (72.4%), laboratory science (73.1%), midwifery (64.3%) and anesthesia students (65%) were this style. Conclusion: Considering the assimilator and converging learning styles among students, it is recommended to use lecture and self learning, visual methods, diagrams, teacher’s handouts, and face to face learning methods. Also, communication skills of medical science students must be supported, because, assimilating and converging have less interest to communicate with others.

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Background: Colorectal cancer is one of the most important and most common fatal types of cancer in the world. Identifying new agents which individually or in combination with other agents induce apoptosis in tumor cells is surely of great significance in treatment of colon cancer. The aim of the present study was to assess the effectiveness of applying lovastatin and α-tocopherol individually or in combination with each other in the induction of apoptosis in human colorectal cancer cells. Materials and Methods: In this trial, HT29 cells were exposed to various concenterations of lovastatin (5, 10, and 20 μmol) and/or alpha tocopherol (10, 20, and 25, and 30 μmol). After cell count, these cells were examined through trypan blue method and DNA fragmentation technique. Results: The findings of DNA fragmentation technique showed that each of the two drugs could induce apoptosis at all of the given concentrations. In the combination of 10 μmol concentration of lovastatin and 5 and 10 μmol concentrations of α-tocopherol, induction of apoptosis was not observed. Conclusion: Based on the extensive effects of statins, the concentration of lovastatin is seen as determining in its apoptosis function, and its combination with tocopheroles in high concentrations, by inducing apoptosis, can provide novel effective strategies for prevention of human colorectal cancer.

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Background: Due to concerns over the negative impacts of PCB compounds on environment and their persistence, their production, use, and import has been banned in some countries. More recently, the Chemical Treaty on Persistent Organic Pollutants (POPs) has listed PCBs among priority chemicals for eventual elimination by 2025. The aim of this study was to determine the effect of solvents on the photodegradation of askarel oils using photolysis for reducing their hazards. Materials and Methods: The photochemical reactor, used in this experimental trial, was based on photolysis through UV/ H2O2 with a 500 ml beaker and low-pressure mercury lamp with a wavelength of 254 nm. The lamp was immersed in the beaker. The temperature and PH of the samples were constantly monitored. The experiments were repeated three times. Askarel oils were analyzed by GC/ECD. Results: The means of degradation of total PCBs due to the use of lamp for ethanol solvent and isooctane were 88% and 77%, respectively. The mean degradation of total PCBs in terms of the applied solvent ratio to the oil transformer for 1:1, 2:1, and 3:1 values for ethanol and isooctane were 55%, 85%, and 88%, and 40%, 77%, and 78%, respectively. Conclusion: Photolysis of PCB compounds in the presence of ethanol solvents, isoocatnes with strong oxidants such as H2O2, indicated their degradation or reduction in oil transformers with lower energy, and no yield of toxic byproducts. There was a significant difference in the employment of ethanol solvent and isooctane in degradation of askarel oil.

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Background: Diabetes is the sixth main cause of mortality in the world, and its both types are accompanied with eye complications in a way that the risk of blindness in diabetic patients is 25 times more than normal people. Hence, this study was conducted to determine diabetic patients’ awareness of the eye complications associated with this disease. Materials and Methods: In a cross-sectional study, 200 diabetic patients referring to the eye clinic of Amir Kabir Hospital of Arak in 2008 were evaluated. Data collection was done through questionnaire and referral interviews. Then some of the factors affecting patients’ awareness of eye complications associated with diabetes were analyzed. Results: The level of awareness of eye complications associated with diabetes in 40% of the patients was average. Also, significant relationships were observed between the level of awareness and age, job, education, type of retinopathy, type of treatment, and the history of referring to ophthalmologist (p<0.001), whereas no significant relationships were observed between the level of awareness and gender, familial history of diabetes, and controlling the diet (p>0.05). Conclusion: This study showed that a higher level of awareness in diabetic patients does not necessitate that they observe a proper diet, but it can lead to patients’ greater care in preventing the development of diabetes

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Background: Hospital wastewater usually contains pathogenic micro-organisms, drugs, radio active materials, and toxic chemical elements that in case of being disposed without filtration, will result in pollution and spread of diseases. Therefore, evaluating the status of wastewater disposal in hospitals is necessary for proper planning. Materials and Methods: In a cross-sectional descriptive study in 2008, data collection was done by means of interviews, observations, and questionnaires in all hospitals of Markazi Province. Noticing the 33 items in the questionnaire, the overall conditions of the hospitals and the methods of using the sewage system were studied, and at the same time, filtration installations and wastewater disposal systems were inspected. Results: Of all the 19 hospitals, 10 used a conventional method of direct disposal of sewage to subterranean shafts, and of the 4 hospitals with filtration installations, three were practically out of order or were not efficient. Five of the hospitals were directly linked to the city sewage system without any pre-filtration. None of the hospitals had a specialized operator of sewage filtration and disposal system. Conclusion: Wastewater disposal in hospitals of Markazi Province is not desirable therefore, such acts as conducting more specific surveys, creating a positive attitude in planners, and providing sufficient funds for filtering wastewater in some of the hospitals are suggested.

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Background: Guillain-Barré syndrome (GBS) has several variant signs and it often presents as an acute monophasic paralyzing illness provoked by a preceding infection. Campylobacter jejuni infection is the most commonly identified cause of GBS while cytomegalovirus, Epstein-Barr virus, and human immunodeficiency virus (HIV) infections have also been associated with GBS. Case: A 55-year-old villager man who was an animal keeper was admitted to Vali-Asr Hospital with symptoms of general weakness, fever, and night sweats. With positive serology of brucellosis (Wright=1:1280, 2ME =1:640), the patient was treated with rifampin, doxycyclin, and tereptomycin (1g/daily). Having received 9 injections of streptomycin, with weakness in the right extremity, the patient was hospitalized. Brain MRI and CT-Scan were reported normal. Within two days, however, the extremity weakness progressed and spread to 4 extremities (2.5 at the proximal and 3.5 in the distal). Generalized areflexia occurred and, three days later, impaired swallowing and facial weakness ensued. Streptomycin was discontinued upon admission. EMG indicated acute and severe demyelinating polyradiculoneuropathy. CSF analysis confirmed Guillain Barre Syndrome while Wright test for CSF was negative. The patient was admitted to the ICU and underwent intubation with progressed paralysis of four limbs, the patient died in 8 days after hospitalization. Conclusion: In endemic areas, brucellosis should be considered in patients with Guillain Barre syndrome.

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Background: H.pylori is one of the most common chronic bacterial infections in population so more than 85 percent are infected in Iran. H.pylori can cause different gastrointestinal disease like gastritis, peptic ulcers and even cancer. One of the effective factors in pathogenesis of bacteria is cytotoxin associated with gene A (cagA). Strains with cagA gene are more virulent. The aim of this study was to determine the frequency of cagA gene of H.pylori in patients with gastric disorders who were admitted to Imam Hossein Hospital, Tehran. Materials and Methods: In this descriptive study, DNA was extracted from 84 paraffin- embedded tissues using QiaAmp tissue kit. H.pylori was verified with PCR of 16sRNA sequences specific for Helicobacter spices and cagA gene was determined using specific primer by the PCR method. The prevalence of cagA gene in three clinical groups gastritis, gastric ulcer, and atrophic patients was compared. Results: Among 84 H.pylori positive isolates ,72 biopsy samples were positive for 16sRNA (85.7%) and 46 (63.9%) for cagA. The prevalence of cagA positive strains in peptic ulcer patients (43.5%) was greater than in those with gastritis (30%). Conclusion: Results showed that Helicobacter pylori strains with cagA are more common in patients with peptic ulcer and cancer.

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Background: Age-related macular degeneration is the most common cause of irreversible central visual loss in individuals over 50 years old. The aim of this study was to assess visual loss due to age-related macular degeneration and some of its associated risk factors. Materials and Methods: This case-control study was conducted on 150 patients with age-related macular degeneration and 150 controls, both aged over 50. A questionnaire on demographic and medical information was completed for each participant and an ophthalmological examination was performed. The results were recorded andthe data were analyzed using SPSS software version 16. Results: Mean age of the subjects in the case and control groups was 78.38 and 79.28 years, respectively.In a multivariable model, hypertension(p=0.003), diabetes(p=0.006), light iris color(p=0.05), hypercholesterolemia (p=0.036), lens opacity (p=0.029), and previous cataract surgery(p=0.029) were significantly associated with age-related macular degeneration. There was not a significant relationship between body mass index (p=0.11) and refractory errors (p=0.94) andage-related macular degeneration. Conclusion: Age-related macular degeneration is associated with hypertension, diabetes, hypercholesterolemia, light iris color, lens opacity, and previous cataract surgery.

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Background: Cataract is the leading cause of blindness and visual impairment. This study was performed to compare effects of two different incision types in cataract surgery on dry eye symptoms and diagnostic test values. Materials and Methods: In this clinical trial, 300 patients with cataract requiring phacoemulsification were studied. The patients were randomly divided into two operative method groups: limbal and clear corneal (anterior to the vascular arcade) incision. A complete set of ophthalmic examinations and tear related tests were done for all of the patients before surgery and one week and one month after surgery. The collected data were analyzed using SPSS and EPI-Info softwares. Results: Overall, 149 men and 151 women were enrolled in this study. On the first postoperative week, the means of symptoms, and TBUT and TMH values in both groups significantly decreased compared with the preoperative values. These values returned to the preoperative levels one month postoperatively which werein contrast to the changes of debri, PEE, corneal and conjnnctival staining. There were statistically significant differences between the results of pre- and post-operative symptoms, PEE, debri, TBUT, conjunctival and corneal staining. Except for TBUT, the results of these tests were not statistically different according to incision location. Conclusion: Phacoemulsification cataract surgery affects dry eye symptoms and diagnostic test values. In addition, except for TBUT, the location of incision had no effect on other test results and symptoms.

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Background: Anthrax is a common disease among human and livestock which is caused by Bacillus anthracis. Bacillus anthracis has two strong immunogenic proteins: Protective antigen (PA) and lethal factor domain I (LFD1) that have always been considered as vaccine candidates against Bacillus anthracis. The aim of this study is to express and purify the lethal factor domain I (LFD1) in Escherichia coli and produce polyclonal antibody against it in mice. Materials and Methods: In this experimental study, LFD1 gene was amplified with BamH I and Xho I restriction site by PCR. After isolation, the gene was cloned to the expression vector pET28a (+). This vector was transformed to E. coli-BL21 (DE3) PLysSto to express LFD1 gene. The expression of LFD1 gene was induced by IPTG. After protein purification by affinity chromatography, the produced antigen was injected into mice for four times. Then the produced polyclonal antibody in mice serum was evaluated. Results: The cloned LFD1 gene in pET28a (+) vector was confirmed by PCR, enzymatic analysis, and sequencing. The expressed and purified recombinant protein was confirmed by SDS-PAGE and Western blotting. Finally, the isolated polyclonal antibody from mice serum was evaluated and confirmed by ELISA test. Conclusion: Noticing the appropriate expression, easy purification of LFD1, and the titer of produced polyclonal antibody against LFD1 in mice due to its immunogenicity, it can be considered as a good vaccine candidate against anthrax.

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Background: The general method for paraclinic diagnosis of epilepsy is electroencephalography that is performed by visual analysis by experienced neurologist. However, due to false detection and impossibility of evaluating electrodes and brain areas coherence, it is not uniquely used for seizure detection. In recent years, Quantitative Electroencephalogram (QEEG) has become a strong instrument for detection of brain disorders. Hence, studies in the field of EEG performance improvement and brain mapping images analysis corresponding to new methods that contain 2-D and 3-D output images and automatic epilepsy diagnosis are necessary.

Materials and Methods: In this cross-sectional study, through extracting epilepsy feature by computing the energy of each EEG channel, brain map pattern of each patient was plotted using cubic interpolation and generalized and partial patterns and potential center of epilepsy were diagnosed by LVQ artificial neural network using image processing combination methods.

Results: In the proposed algorithm, 11 epilepsy brain mapping patterns, including 1 generalized and 10 partial seizure patterns, were automatically diagnosed.

Conclusion: Since seizure detection in the EEG signals is a complex procedure and the number of expert neurologists is small, this schema can be used for epilepsy diagnosis as an intelligent diagnosis method so that generalization of this method can help detect various brain disorders.

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Background: Cotonary artery illneses are the common heart illness that there is treatment methods now, many patients need the coronary artery bypass graft. Anxiety is a common phenomenon after all surgical operation. Anxiety in coronary artery bypass graft causes to increase metabolic rate, decrease immunity of body, and increases activity of heart coronary and gastrointestinal. This study was perfound to assess the effects of metatarsus foot reflexology on state anxiety levels after coronary artery bypass graft in Imam Ali Hospital Kermanshah.

Methods and Materials: This clinical trial included 88 patients that they were divided in to the intervention and control group based on the randomly. The intervention group received a 10 minute right foot massage one day on third and fourth day after coronary artery bypass graft and control group received no intervention, only at the time mentioned, score anxiety was measured with standard questionnaire spielberger.

Results: Patients state anxiety significanty decreased in the intervention group in the third day comparison with the control group, but no difference were not observed in the control group.

Conclusion: The finding of the study showed foot reflexology to be effective and simple that complication and damages are low that is used in reducing patients anxiety in treatment-health centers.