Showing 15 results for Rajabi
Akram Ranjbar, Hajar Rajabian, Yhya Jand, Elahe Mirza Zadeh, Akram Esmaili , Sara Ghasemi Nejad , Ali Akbar Malekirad,
Volume 7, Issue 3 (Autumn 2004)
Abstract
Introduction: Disturbance between production of free radicals and antioxidant defense is named oxidative stress. One of the main sources of free radicals is smoking that induce oxidative stress.
Materials and Methods: This is a cross sectional study in which questionnaires including information such as age, sex, education, history and number of smoking and history of special disease were filled. Case group were smokers (n=43) who were smoking at least 5 years and their mean age was 37.7 year. The control group was consisted of 43 nonsmokers which were matched for age and sex. They were evaluated for oxidative stress markers including thiobarbituric acid reactive substance (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total thiol (SH) groups and gammaglutamyl transferase (GGT) levels in blood.
Results: Results showed that induction of oxidative stress in smokers as revealed by decreased FRAP (1.89±0.03 vs 2.24±0.04, p=0.01) and plasma Sh groups (0.22±0.08 vs 0.81±0.48, p=0.01) in comparison to those of controls. The activity of GGT and level of LPO increased but were not significant . Also the correlation between history of smoking and oxidative stress was not significant.
Conclusion: It is concluded that smoking have decreased FRAP and SH groups which may put smokers at future consequences of oxidative stress. It seems that improving antioxidant system in smokers is effective.
Mohammad Reza Palizvan, Hajar Rajabian, Elahe Mirzazadeh, Yahya Jand, Ehsan Alah Ghaznavi Rad,
Volume 11, Issue 4 (12-2008)
Abstract
Background: Although the roles of steroid hormones in the activation and maintenance of reproductive function are proved well, emerging evidence indicated that these steroids influence on performance of learning and memory. These effects are complex and vary with task, gender, and age, as well as the regimens of steroid exposure. This study was carried out in order to assess the role of progesterone administration in newborns rats on Morris water maze learning ability after adolescence.
Methods and Materials : This experimental study was carried out on 36 newborns Wistar rats. Rats were divided randomly into 6 groups female progesterone, male progesterone, female sesamoide, male sesamoid rats and male and female control rats. Progesterone groups were treated with a single injection of progesterone (100 mg/kg) and sesamoid groups were received the same volume of sesamoid oil as the progesterone vehicle in day 1 or 2 after brith, 60 days later, spatial memory ability was determined in Morris water maze.
Results : The results of this study show that water maze learning can enhance by administration of sesamoid oil in newborn female pups in compared to progesterone and control groups (p<0.05). In addition, adding progesterone to sesame oil reduce water maze learning to control level.
Conclusion: The hypothesis that progesterone impaired spatial reference memory in female rats was supported by this experiment.
Mohammad Narimani, Soran Rajabi, Sima Delavar,
Volume 16, Issue 2 (5-2013)
Abstract
Background: Based on the association between beta (13-30 Hz) and attention and alertness and theta (4-8 Hz) and a hypnagogic state and less attention, the possibility of training attention deficit and hyperactivity disorder (ADHD) individuals in order to enhance their symptoms was investigated. Thus, the purpose of this study was to determine the effectiveness of neurofeedback training on students with ADHD symptoms.
Materials and Methods: This interventional study was conducted with an experimental group and a control group. A total of 34 female students with high scores on Conners adult questionnaire and theta/beta ratio in Mohaghege Ardebili University, Iran, were randomly selected and then assigned to neurofeedback training and control groups. Neurofeddback training (NF) was used with an experimental group in twenty sessions and the control group received no training. Data were gathered using the neurofeedback system (NFT), the continuous performance test (CPT), the short diagnostic hyperactivity disorder- Conners adult questionnaire. Multivariate analysis of covariance (MANCOVA) was used for analyzing the data.
Results: The results indicated that neurofeedback training affected all dimensions of CPT and short diagnostic hyperactivity disorder (P<0.001).
Conclusion: The findings suggest the positive effect of neurofeedback training on treating attention problems and reducing the symptoms of hyperactivity in female students with hyperactivity and attention deficit in comparison with the control group.
Razie Rajabi, Akram Sharifi, Mohsen Shamsi, Amir Almasi Hashyani, Somayeh Dejam,
Volume 17, Issue 5 (8-2014)
Abstract
Background: Planning of educational programs to inform the people about the prevention of diseases such as cancers is necessary. This study was conducted to determine the effect of educational interference based on HBM on practices of women about gastric cancer.
Materials and Methods: In this semi-experimental study, 88 women participated from Arak. The subject were randomly divided in two groups, experimental group and control group (each group includes 44 women). Inclusion criteria were absence of cancer, Iranian nationality, age over 18 years, living in the city. Data collected with a questionnaire based on HBM and performance checklist about colorectal cancer prevention was used in order to evaluate the effectiveness of the educational program. Intervention was done in 1 month consist of 3 session each session 45 minutes. Three months later data were recollected and analyzed.
Results: In this study, the mean age in case and control group was 38.3±9.6 and 36.3±11.1 years respectively, with no significant differences (p=0.381). Average scores of knowledge and practice in experimental was 72.8±13.06 and 30.81±6.2 respectively group before the intervention, which was 88.05±12.2 and 65.3±8.9 respectively after the intervention (p<0.05). Moreover before of intervention susceptibility, severity and percieved benefit about practice of mothers was moderate but after intervention the entire items between experimental and control groups was significantly different (p<0.05).
Conclusion: Finding of this research confirms the effect of Health Belief Model on prevention from gastrointestinal cancer in women of Arak.
Reyhaneh Mansouri, Reza Rajabi, Hooman Minoonejad,
Volume 18, Issue 2 (5-2015)
Abstract
Background: It seems that using shuttle balance which has recently been produced in Iran would be beneficial in exercise prescription for preventing sports injuries and recovery. The purpose of this study is comparing the amount of the electromyography activity of involved muscles in ankle strategy while standing on one leg on shuttle balance versus wobble board.
Materials and Methods: This study is a functional and cause-compare study. 15 female students 20-22 years of age having the enterance standards were selected meaningfully. The amount of EMG activity of selected muscles (Tibialis Anterior, Gastrocnemius, Rectus Femoris and Hamstring) was measured while standing on one leg on two devices. The difference in means of muscles activity in both of devices was estimated using multivariate analysis of variance.
Results: The results showed a significant difference between the amount of EMG activity of involved muscles (p=0.001). Also, the results of the intragroup effects showed that the electromyography activity of Tibialis Anterior, Rectus Femoris and Hamstring while standing on shuttle balance was significantly more than the activity while standing on wobble board (p<0.05). While the amount of activity on shuttle balance was higher as compared to wobble board, but there was no significant difference in Gastrocnemius EMG activity between two devices (p>0.05).
Conclusion: It seems that standing on shuttle balance can make higher electromyography activity in the muscles that are involved on ankle and thigh joints, i.e. Tibialis Anterior, Rectus Femoris and Hamstring. So it is recommended that shuttle balance can be used in balance training program.
Raziyeh Kheirjou, Mohammad Hasan Heidari, Mohammad Bayat, Masoumeh Rajabi Bazl, Rasoul Ganji, Abbas Piryaei,
Volume 18, Issue 5 (8-2015)
Abstract
Background: Wound healing is a complex process that is impaired in diabetic patients due to several factors. So far, the positive effects of mesenchymal stem cells secretions in wound healing process have been reported. In this study, we investigated the effect of human mesenchymal stem cells Conditioned media on expression of effective factors involved in wound healing.
Materials and Methods: 27 rats were divided into 5 groups: no wound control, normal control, diabetic control, diabetic placebo and diabetic experimental. Diabetes was induced by Alloxan. A wound was created on the back of the rats. Then, the conditioned medium was prepared from mesenchymal stem cells. Diabetic experimental rats received 200 microliter of conditioned medium intravenously. The wounds were sampled and expression of KGF and TGF-&beta1 genes was examined by RT-PCR on days four and seven after wounding.
Results: In the diabetic experimental group, expression of KGF gene at fourth and seventh days had been non-significantly increased in comparison to diabetic control group. While, expression of TGF-&beta1 gene in diabetic experimental group compared to diabetic control group had been significantly (p<0.05) increased on fourth day, and non-significantly increased on seventh day.
Conclusion: It seems that using the conditioned medium derived from human mesenchymal stem cells positively affects the expression of trophic and inflammatory factors involved in diabetic skin wound healing.
Hasan Izanloo, Shahram Nazari, Mohammad Ahmadi Jebelli, Soodabeh Alizadeh Matboo, Hamid Reza Tashauoei, Behnam Vakili, Mohammad Rajabi, Hosein Aghababaei, Gharib Majidi,
Volume 18, Issue 6 (9-2015)
Abstract
Background: Dendrimers are a subset of branched structures that have certain structural order. The aim of this study was to investigate the performance of Polypropylenimine-G2 (PPI-G2) dendrimers in removal of Escherichia coli, Proteus mirabilis, Bacillus subtilis and Staphylococcus aureus from aqueous solution .
Materials and Methods: In this experimental study , initially dilution of 103 CFU/ml was prepared from each strain of bacteria . Then , different concentrations of dendrimers (0.5, 5, 50 and 500 µg/ml) was added to water . In order to determine the efficiency of dendrimers in removal of bacteria, samples were taken at different times (0, 10, 20, 30, 40, 50 and 60 min) and were cultured on nutrient agar medium . Samples were incubated for 24 hours at 37 ° C and then the number of colonies was counted .
Results: By the increasment of dendrimer concentration and contact time , the number of bacteria in aqueous solution decreased. In times of 40 , 50 and 60 minutes, and the concentrations of 50 and 500 µg/ml, all kinds of bacteria in aqueous solution were removed . 0.5 µg/ml of dendrimer concentration had not effect in reducing the number of Escherichia coli and Proteus mirabilis . The effect of dendrimer on gram-negative bacteria was weaker than gram-positive bacteria.
Conclusion: Results of this study indicated that PP I -G2 dendrimer is able to remove Escherichia coli , Proteus mirabilis , Staphylococcus aureus and Bacillus subtilis in aqueous solution. However, using dendrimers can be considered as a new approach for drinking water disinfection but it requires further wide range studies.
Sara Vali Zadeh, Pezhman Motamedi, Hadi Karami, Hamid Rajabi,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Type 2 diabetes exerts an anti-angiogenesis effects on the cardiac tissue. The aim of present study was to investigate the effects of endurance training on gene expression of VEGF and VEGFR2 of cardiac tissue in type 2 diabetic male wistar rats.
Materials and Methods: 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (DET), Diabetic Control (DC) and Healthy Control (HC). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min and intensity of 75% VO2max for 20-30min in 1st week and reached to 27 m/min and intensity of 75% VO2max for 60 min/day in 10th weeks. The gene expression of VEGF and VEGFR2 were examined by Real-Time PCR AND Western Blotting.
Findings: The results of Real-Time PCR showed that the endurance training caused increase in VEGF mRNA (p<0.05) and VEGFR2 mRNA (p<0.05) compared to DC group. The results of Western Blotting also indicated that the endurance training induced increase in VEGF protein expression (p<0.05) compared to DC group and there was no significant change in expression of VEGFR2 protein (p>0.05).
Conclusion: Type 2 diabetes impairs the angiogenesis process in diabetic cardiac. It appears that endurance training has positive impact on angiogenesis and it can cause the improvement of diabetic cardiac.
Ali Asghar Ghorbanalipour, Pezhman Motamedi, Hamid Rajabi, Hadi Karami,
Volume 21, Issue 7 (2-2019)
Abstract
Background and Aim: The eNOS gene that is responsible for the production of nitric oxide and angiostatin is an inhibitor of angiogenesis. The aim of present study was to investigate the effect of endurance training on angiostatin and eNOS gene expression of cardiac tissue in type 2 diabetic male wistar rats.
Materials and Methods: In an experimental study, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (DET, n=12), Diabetic Control (DC, n=12) and Healthy Control (HC, n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 15 minutes in 1st week and reached to 27 m/min for 60 min/day in 9th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of angiostatin and eNOS were examined by Real-Time PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05.
Ethical Considerations: This study was approved in Research Ethics Committee of Arak university of medical sciences with the code IR.ARAKMU.REC.1394.329.
Findings: The gene expression of angiostatin and eNOS of DC group showed significant increase compared to HC group (p =0.000). The endurance training induced significant decrease in the gene expression of angiostatin and eNOS compared to DC group (p =0.000).
Conclusion: It appears that gene expression of angiostatin and eNOS of diabetic cardiac tissue are affected by positive effect of endurance training.
Saeed Hajihashemi, Razie Rajabi, Atefeh Ghiasabadi Farahani,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim Gentamicin antibiotic has some side effects such as nephrotoxicity. The aim of this study was to evaluate the post-treatment effects of using hydroethanolic extract of Origanum Vulgare (OV) on nephrotoxicity caused by gentamicin.
Methods & Materials In this study, 32 male Wistar rats were divided into four groups of control (n=8), gentamicin (n=8; 100 mg/kg/day intraperitoneally for 8 days and gavage of distilled water for 2 days), OV extract group (intraperitoneal injection of normal saline for 8 days and using 40 mg/kg OV extract by gavage for 2 days), and gentamicin+ OV extract (intraperitoneal injection of gentamicin 100 mg/kg/day for 8 days and using 40 mg/kg OV extract by gavage for 2 days). The concentration of urea, creatinine, sodium, potassium and osmolarity were measured in plasma and urine samples. The right kidney was used to measure Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP).
Ethical Considerations This article was obtained from a research proposal approved by the Research Ethics Committee of Arak University of Medical Sciences (Code:IR.ARAKMU.REC. 1394.284)
Results Post-treatment administration of hydroethanolic extract of OV significantly decreased the concentration of urea, creatinine, absolute sodium excretion, relative sodium and potassium excretion, and MDA levels but significantly increased creatinine, urine osmolality and FRAP levels.
Conclusion Oral administration of OV extract as post-treatment method improved nephrotoxicity caused by gentamicin use by reducing oxidative stress of oxygen free radicals and lipid peroxidation in the affected kidneys.
Mahboubeh Sheikhan, Mohammad Reza Kordi, Hamid Rajabi,
Volume 23, Issue 4 (October & November 2020)
Abstract
Background and Aim: Several microRNAs are involved in regulating muscle mass, which plays an essential role in hypertrophy and atrophy of skeletal muscle, The present study examined the expression of some genes as regulators of muscular atrophy following a period of inertia in rats.
Methods & Materials: For this purpose, 18 male Sprague-Dawley rats were divided into three groups (Control, Exercise+inactivity, and Inactivity). The exercise+inactivity group run on the treadmill for 18 weeks and five times per week. The hindlimb of the animal was immobilized for seven days with the casting method. Soleus muscle was extracted and the expression of the genes was measured by the RT-PCR method. Univariate ANOVA and Tukey post hoc test was used to determine the differences (α=0.05).
Ethical Considerations: The Ethics Committee of the Tehran University of Medical Sciences Research approved this study (Code: IR.SUMS.REC.1396.S 463).
Results: Results showed that immobilization in both Exercise+ inactivity and inactivity groups, compare to the control group, increased expression of miR-1 genes (P<0.10), FOXO3a (P<0.001) and decreased expression of miR-206 (P<0.007) and IGF-1 (P<0.001). This difference was statistically significant.
Conclusion: According to the results of this study, it can be said that changes in the expression of RNAs by chromatography cause changes in the expression of muscle regulating genes, and although endurance exercises have protective effects, they cannot prevent these changes.
Ali Azam Rajabian, Mohammad Javad Asghari Ebrahimabad, Hamidreza Aghamohammadian Sharbaf, Seyed Kazem Rasoolzadeh Tabatabaei,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and Aim There is almost no accurate information about the causes of body dysmorphic disorder. Many patients with body dysmorphic disorder who apply for plastic surgery show a negative response to these treatments and sometimes the symptoms get worse. The purpose of the present study was to investigate the causes of body dysmorphic disorder in women.
Methods & Materials The present research was a qualitative study with a content analysis type. Variables and categories were obtained by interviewing 15 experts and eight people with body dysmorphic disorder and reviewing 71 articles. Also, to diagnose body dysmorphic disorder, Yale Brown’s Practical Obsession Questionnaire was used in addition to the interviews. The sampling method in this research was purposive sampling. Data analysis was done in three stages: open, central, and selective coding. The validity of the components was checked by calculating the content analysis index.
Ethical Considerations In the research, before the interview, written consent was received regarding the specificity and confidentiality of the research (Code: IR.UM.REC.1401.105).
Results The influential factors in body dysmorphic disorder were: a. Cultural and social factors b. Psychological factors, and c. Biological factors.
Conclusion According to the obtained results, several factors play a role in the occurrence of body dysmorphic disorder, and their identification in different environments, cultures, and societies provides the possibility of developing preventive measures, and designing and developing a suitable treatment model. However, to increase the external validity of the research, it is suggested to conduct similar research in other societies.
Abolfazl Kalantari, Hamid Rajabi, Pezhman Motamedi, Leila Poursaadat, Abbas Saremi,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: Increasing skeletal muscle contraction ability via increasing its neural stimulations, is one of the methods can be effective in sport performance improvement. The aim of the present study was to evaluate the effect of supramaximal isometric conditioning contractions on muscle neural excitation and performance indices during bench press exercise.
Methods: Current research is a semi experimental study performed on 8 athlete men. Age range of them was 19 – 23. Doing resistance trainings was a part of their exercise program at least 2 months before study onset. Bench press with Barbell was used in the protocol of these study. Electromyography was used in order to assay the neural excitation of main muscles which are activated during bench press. In addition, 1-RM test was done so as to assess the performance of these muscles. The protocol of this study was approved by the ethics committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1400.357). All subjects participated in this study voluntarily and they had no illness or injury at the start of the research.
Results: Neural excitation and performance of the muscles increased significantly during strength bench press, following conditioning contractions. This research was reviewed in Islamic Azad University - Arak Unit and approved with the ethics code IR.IAU.ARAK.REC.1401.096. Informed consent was obtained from the participants and they were assured that their information would be confidential
Conclusions: Doing supramaximal isometric conditioning contractions prior to doing strength bench press with barbell, increased neural excitation and performance indices of main muscles activated in this exercise.
Miss Zahra Mortezaei, Dr Somayeh Rajabi, Dr Sayyed-Javad Ziaolhagh,
Volume 26, Issue 3 (August & September 2023)
Abstract
Introduction: Methamphetamine increases the release of dopamine from nerve terminals. Binding of dopamine to dopamine receptors increases the phosphorylation of cyclic adenosine monophosphate responsive element (CREB) protein and changes the transcription of downstream genes.The purpose of this study is to investigate the effect of methamphetamine induction followed by aerobic training and Berberine on dopamine receptor 4 and CREB gene expression in the heart tissue of methamphetamine-addicted female rats during the withdrawal period.
Methods: 30 rats were randomly divided into 5 control groups, methamphetamine, methamphetamine + aerobic training, methamphetamine + Berberine, methamphetamine + aerobic training + Berberine. Intraperitoneal injection of 10 mg/kg of methamphetamine was performed for 5 days, and during the withdrawal period, aerobic training was performed for 4 weeks and simultaneously the consumption of berberine 100 mg/kg as a solution in drinking water was considered. Real Time PCR method was used to measure gene expression. Independent T-test, Kruskal-Wallis test and SPSS24 software were used at the level of 0.05 to analyze the data. The code of ethics in the research was received with number IR.IAU.SHAHROOD.REC.1402.015.
Results: The results showed that methamphetamine use caused a non-significant increase (97%) in CREB expression and a non-significant decrease (52%) in dopamine 4 receptor compared to the control group (P>0.05). The implementation of interventions during the withdrawal period, such as Berberine consumption and the combination of berberine with aerobic training, produced non-significant increasing and decreasing effects on dopamine 4 receptor gene expression and CREB in the heart of methamphetamine-addicted rats, respectively (P > 0.05).
Conclusions: Short-term induction of methamphetamine did not cause significant changes in the expression of dopamine 4 receptor and CREB genes in the heart. Therefore, these genes could not undergo a significant change as a result of interventions such as Berberine and exercise. More studies are needed to investigate exact genetic changes in heart tissue.
Professor Hamid Rajabi, - Marjan Sheidaee, - Neda Khaledi,
Volume 26, Issue 6 (February & March 2024)
Abstract
Introduction: Athletes use diverse strategies, including caffeine supplementation, to reduce fatigue and improve their performance. The aim of the present study was to evaluate the effect of the post-activation potentiation method and caffeine supplementation on peripheral fatigue after Wikstrom's fatigue protocol in young male volleyball players.
Methods: In this study, forty male volleyball players with an average age of 27.33 ± 1.78 years and an average weight of 76.5 ± 7.45 kg participated. They were divided into four experimental groups: a group that used only the PAP method (n=10), a group that consumed only caffeine (n=10), a group that both performed PAP and consumed caffeine (n=10), and a control group (n=10). For the groups receiving caffeine, a caffeine supplement was administered at a dose of 6 mg per kilogram of body weight, 15 minutes before starting the protocol. PAP exercises were performed at an intensity of 70% of the one-repetition maximum. Blood samples were taken one hour before and one hour after completing the Wikstrom six-station protocol. All subjects participated in this study voluntarily and they had no illness or injury at the start of the research.
Results: The results of the present study showed that the implementation of PAP along with caffeine showed a significant increase in the variables of time to exhaustion and the number of rounds (p<0.05), while the rate of ammonia showed a significant decrease (p<0.05). In contrast, uric acid showed no significant difference (p>0.05).
Conclusions: The results of the present study, showed that the use of caffeine reduces peripheral fatigue. Also, since the use of PAP did not have an adverse effect on the participant's performance, athletes can use this method concurrently with caffeine to improve their performance in endurance activities.
