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Abstract Background: Prostate cancer is the most common cancer in American's men and is the most common malignancy after skin in men. The purpose of this research was comparison of demographic characteristic of patients with advanced prostate cancer treated with surgical and medical orchiectomy. Materials and Methods: This retrospective cross- sectional analytic study carried out on 53 patients with locally advanced and metastatic (stages III- IV) prostate cancer referring to oncology wards in Buali hospital in Hamadanand and Vali-e-Asr hospital in Arak for adjuvant therapy of chemotherapy or radiotherapy during 2003-7. Demographic characteristics such as age, disease stage, cultural status, habitancy, socioeconomic status and patients accepted treatment of advanced prostate cancer treated with surgical and medical orchiectomy (hormone therapy), were determined and compared. Results: There was a significant difference between age mean of patients treating by orchiectomy and hormone (p=0.007). Also socioeconomic status distribution in two groups was different (p= 0.025). Distribution of disease stage, cultural level, habitancy in two groups were similar (respectively p=0.207, p=0.617, p=0.272). Conclusion: People less tend to orchiectomy to hormone therapy. Also, in high socioeconomic status and in elder, tendency to surgical orchiectomy is more.

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Background: The Real-time PCR assay has been established as the standard method for Human Cytomegalovirus (HCMV) quantitation in immunocompromised patients. However, the question of which one of whole blood or plasma specimens is better for viral quantitation is still unresolved for many clinical laboratories. To answer this question, the current study compares HCMV DNA load in whole blood and plasma samples.

Materials and Methods: In this prospective study, the whole blood and plasma samples were obtained from 41 transplantated patients and the viral load was detected using a validated, in-house Real-time PCR assay.

Results: Of the total 193 examined specimens, 174 were negative and 19 samples, from 16 patients, were positive in at least one of whole blood or plasma samples. Based on the results of linear regression analysis, the cytomegalovirus viral load was correlated in whole blood and plasma samples (R2: 0.872). However, the regression equation shows that the HCMV load in whole blood samples is higher than load of this virus in plasma. The validity of the quantitative results was confirmed by repeating the tests and analyzing the results using the repeated measure analysis.

Conclusion: Based on the results of the present study, HCMV quantitation in whole blood samples has a higher analytical sensitivity than in plasma samples.

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Background: Today, occupational health of nurses in the health care system is important. This study aimed to investigate the relationship between death anxiety, sleep quality and job satisfaction of nurses working in Arak university of medical sciences hospitals in 2015.

Materials and Methods: The research method was descriptive, correlational and cross-sectional. The population included nurses in public hospitals affiliated with Arak university of medical sciences. The samples included 309 nurses that were simply and randomly selected. Data were collected with Herzberg job satisfaction, Pittsburgh sleep quality questionnaires and death anxiety scale. Data were analyzed using descriptive and inferential statistics.

Results: The results showed that the relationship between job satisfaction with sleep quality of nurses was significant, but there was not a significant relationship between job satisfaction and quality of sleep with death anxiety of nurses. In addition, there was a significant telationship between diffevent parts of hospitals in job satisfaction and death onxiety, although this difference was not significant in quality of sleep. Job satisfaction was the only factor that was significant in the group with the possibility of difficult working conditions.

Conclusion: According to the research findings, it seems that paying attention to sleep quality sleep is important to improve nurses satisfaction. Job satisfaction is also influenced by the hard conditions of work and requires more attention to a group of nurses who are working in such a situation. Also, a higher death anxiety than usual in nurses requires more study and reflection.

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Abstract

Background: 4cure models are a model to analyze survival data that these models exist for long term survivors. Cure models are a special type of survival model where it is assumed that there are a proportion of subjects who had never event, thus, survival curve will eventually reach a plateau. Therefore, standard survival models are not appropriate because they do not account for the possibility of cure.The aim of the present research is to apply non-mixture cure model to analyze survival of patients with colorectal cancer.

Materials and Methods: We studied 232 patients with colorectal cancer who were visited and treated at Taleghani Hospital Research Center for Gastroenterology and Liver Disease in Tehran. These patients were diagnosed from 1987 to 2012 and followed up until 2013. The Effect of age, gender, family history, body mass index and site of infection were studied. Kaplan-Meier and Non-Mixture cure Model were used for analzing data.

Results: The ten-year survival rate after diagnosis in the studied patients was 64 % .A total of 60 (25.8 %) deaths due to colorectal cancer were observed. The mean of age at the time of diagnosis was 51.6 years. Based on non-mixed cure model, the rangs of age was 45-65 years old and BMI were significant.

Conclusion: When the population is divided into two groups (susceptible and non- susceptible individuals), using Cox semi-parametric model is not appropriate. Therefore, we should use cure models.

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