Showing 7 results for Rafei
Esmat Mashhadi, Marjan Rafigh, Ali Ghazavi, Mohammad Rafei, Ghasem Mosayebi,
Volume 12, Issue 1 (5-2009)
Abstract
Background: Hypertension disorders are the most common medical complication during pregnancy. Preeclampsia is an important cause of mortality. The pathophisiology of it is still unknown. But sex hormon especially testosterone may be has a role in preeclampsia. We were conducted the comparison of serum free testosterone level in preeclamptic with normotensive pregnant women. Methods and Materials: This research was a case-control study included 27 women with singleton pregnancy who were complicated with preeclampsia (11 with severe preeclampsia and 16 with mild preeclampsia) and 62 normotensive pregnant women who were matched for age, body mass index (BMI) and gravity. Serum levels of free testosterone were measured by ELISA method. Results:Serum testosterone level was higher in preeclamptic group (1.66 ng/ml) than in mean of the control group (1.27 ng/ml), but this difference was not significant. Mean of testosterone levels in sever preeclampsia were higher than mild preeclampsia patients, however it was not statistically significant (2.08, 1.37, respectively). Conclusion: It seems that testosterone has not significant role in the pathogenesis of preeclampsia. .
Mohsen Khaki, Ali Ghazavi, Keyvan Ghasami, Mohamad Rafei, Mohammad Payani, Ghasem Mosayebi,
Volume 12, Issue 2 (9-2009)
Abstract
Background: Multiple sclerosis (MS) is a auto-immune disease of central nervous system. The etiology of MS is unknown, but environmental factors such as viruses are involved in the development of MS. In this study, MS patients were assessed for antibodie titers against Human Herpes virus-6 (HHV-6) in Markazi Province. Methods and Materials: In this case-control study, 31 new cases of MS patients and 60 healthy subjects were selected with similar demographic criteria such as sex, age and location. Antibodies titer (IgM and IgG) against HHV-6 were examined by ELISA and Immunofluorescence methods. Data were analyzed using Logistic regression and Odds ratio. Results: Data indicates that 74.2% of case group and 34.2% of control group were identified as positive for IgM against HHV-6. The difference between the two groups in terms of IgM against HHV-6 was statistically significant (p=0.001). Incidence of IgM positivity against HHV-6 was increased more than five times in MS patients compared to control group. Also there was a statistically significant difference between case and control groups in IgG titer (p=0.019). Conclusion: Acute infection of HHV-6 is a risk factor for MS.
Mahmood Reza Baghinia, Fatollah Mohaghegh, Mohammad Rafeie,
Volume 12, Issue 3 (10-2009)
Abstract
Abstract Background: Prostate cancer is the most common cancer in American's men and is the most common malignancy after skin in men. The purpose of this research was comparison of demographic characteristic of patients with advanced prostate cancer treated with surgical and medical orchiectomy. Materials and Methods: This retrospective cross- sectional analytic study carried out on 53 patients with locally advanced and metastatic (stages III- IV) prostate cancer referring to oncology wards in Buali hospital in Hamadanand and Vali-e-Asr hospital in Arak for adjuvant therapy of chemotherapy or radiotherapy during 2003-7. Demographic characteristics such as age, disease stage, cultural status, habitancy, socioeconomic status and patients accepted treatment of advanced prostate cancer treated with surgical and medical orchiectomy (hormone therapy), were determined and compared. Results: There was a significant difference between age mean of patients treating by orchiectomy and hormone (p=0.007). Also socioeconomic status distribution in two groups was different (p= 0.025). Distribution of disease stage, cultural level, habitancy in two groups were similar (respectively p=0.207, p=0.617, p=0.272). Conclusion: People less tend to orchiectomy to hormone therapy. Also, in high socioeconomic status and in elder, tendency to surgical orchiectomy is more.
Behzad Khansarinejad, Mahdieh Mondanizadeh, Mohammad Rafeie, Siamak Mirab Samiee,
Volume 17, Issue 4 (7-2014)
Abstract
Background: The Real-time PCR assay has been established as the standard method for Human Cytomegalovirus (HCMV) quantitation in immunocompromised patients. However, the question of which one of whole blood or plasma specimens is better for viral quantitation is still unresolved for many clinical laboratories. To answer this question, the current study compares HCMV DNA load in whole blood and plasma samples.
Materials and Methods: In this prospective study, the whole blood and plasma samples were obtained from 41 transplantated patients and the viral load was detected using a validated, in-house Real-time PCR assay.
Results: Of the total 193 examined specimens, 174 were negative and 19 samples, from 16 patients, were positive in at least one of whole blood or plasma samples. Based on the results of linear regression analysis, the cytomegalovirus viral load was correlated in whole blood and plasma samples (R2: 0.872). However, the regression equation shows that the HCMV load in whole blood samples is higher than load of this virus in plasma. The validity of the quantitative results was confirmed by repeating the tests and analyzing the results using the repeated measure analysis.
Conclusion: Based on the results of the present study, HCMV quantitation in whole blood samples has a higher analytical sensitivity than in plasma samples.
Ehsan Kasraie, Mohammad Rafeie, Saeid Mousavipour,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Today, occupational health of nurses in the health care system is important. This study aimed to investigate the relationship between death anxiety, sleep quality and job satisfaction of nurses working in Arak university of medical sciences hospitals in 2015.
Materials and Methods: The research method was descriptive, correlational and cross-sectional. The population included nurses in public hospitals affiliated with Arak university of medical sciences. The samples included 309 nurses that were simply and randomly selected. Data were collected with Herzberg job satisfaction, Pittsburgh sleep quality questionnaires and death anxiety scale. Data were analyzed using descriptive and inferential statistics.
Results: The results showed that the relationship between job satisfaction with sleep quality of nurses was significant, but there was not a significant relationship between job satisfaction and quality of sleep with death anxiety of nurses. In addition, there was a significant telationship between diffevent parts of hospitals in job satisfaction and death onxiety, although this difference was not significant in quality of sleep. Job satisfaction was the only factor that was significant in the group with the possibility of difficult working conditions.
Conclusion: According to the research findings, it seems that paying attention to sleep quality sleep is important to improve nurses satisfaction. Job satisfaction is also influenced by the hard conditions of work and requires more attention to a group of nurses who are working in such a situation. Also, a higher death anxiety than usual in nurses requires more study and reflection.
Zahra Abdolalian, Mohammad Rafeie, Ahmad Reza Baghestani, Mohamad Amin Pourhosseingholi, Tahoura Daneshvar,
Volume 19, Issue 9 (12-2016)
Abstract
Abstract
Background: 4cure models are a model to analyze survival data that these models exist for long term survivors. Cure models are a special type of survival model where it is assumed that there are a proportion of subjects who had never event, thus, survival curve will eventually reach a plateau. Therefore, standard survival models are not appropriate because they do not account for the possibility of cure.The aim of the present research is to apply non-mixture cure model to analyze survival of patients with colorectal cancer.
Materials and Methods: We studied 232 patients with colorectal cancer who were visited and treated at Taleghani Hospital Research Center for Gastroenterology and Liver Disease in Tehran. These patients were diagnosed from 1987 to 2012 and followed up until 2013. The Effect of age, gender, family history, body mass index and site of infection were studied. Kaplan-Meier and Non-Mixture cure Model were used for analzing data.
Results: The ten-year survival rate after diagnosis in the studied patients was 64 % .A total of 60 (25.8 %) deaths due to colorectal cancer were observed. The mean of age at the time of diagnosis was 51.6 years. Based on non-mixed cure model, the rangs of age was 45-65 years old and BMI were significant.
Conclusion: When the population is divided into two groups (susceptible and non- susceptible individuals), using Cox semi-parametric model is not appropriate. Therefore, we should use cure models.
Hamideh Mohammadnia Kojidi, Mohammad Rafeie, Mohammad Ali Daneshmand, Jalal Rezaei,
Volume 21, Issue 2 (5-2018)
Abstract
Abstract
Background: Early diagnosis of prenatal illnesses and timely treatment of congenital anomalies has been the mainstay of the health system. In this study, our aim is to provide Roc curve multivariate modeling in detection of fetal abnormalities using associated markers in screening Down syndrome in the first and second periods of pregnancy.
Materials and Methods: This is a descriptive-analytical study that uses information from two sets of data. In the first set, 152 individuals, who had the results of the first- trimester and second screening tests at risk and in the second group, 75 individuals with normal results. The studied variables included the serum markers in the first- trimester and the second- trimester screening, auxiliary variables (includes demographic information). Statistical analysis was performed by using ROC regression, incremental value analysis and Stata 12 software.
Results: In evaluating the value of each diagnostic test in the presence of auxiliary variables using logistic regression and rock curves, the results generally showed that in screening the first- trimester of PAPP-A and in the screening the second-trimester,Inhibin-A can be used alone as a diagnostic test.
Conclusion: Best diagnostic test in the first- trimester, respectively, PPAP-A, NT, FREE B-HCG and in the second- trimester of screening, respectively, Inhibin-A, HGG, UE3 and AFP were based on the area under the ROC curve. In addition, the most significant effect of the predictor variable on the outcome of the diagnostic test was family history.
