Showing 11 results for Pedram
Mahmoud Pedram,
Volume 1, Issue 2 (Spring 1997)
Abstract
The retention of 500-900 meq sodium and 6-8 litre water, which is b diffused between extracellular fluid space of mother and fetues is performed in pregnancy slowly. When plasma volume increase by 30-50%, mean blood pressure decreases by 15% approximately. In the second half of the pregnancy, blood pressure increases slowly and it returns to its previous status, in the period of term. GFR is increases by 30-50% in the twelfth week of pregnancy, and it remains steady until the term period .Glucosuria and Aminoaciduria may be observed during the pregnancy. In this time ureters are dilated and it continues until the twelve weeks after delivery. The cardiac output goes up in the primary trimester and then it remains fixed until the term. Hypertension is still one of the main reason of morality both in mother and infetus. The best division of blood pressure in the pregnancy has advocated by American college of Gynecologist, which has got 4 parts:
A: hypertension which exactly relates to pregnancy ( Eclampsy , Pre-eclampsy)
B:chronic Hypertension with other causes
C:Chronic Hypertension which has been added by pre _Eclampsy
D: Pregnancy induced Hypertension
The other crucial problems in pregnancy is acute renal failure , which may be causes by renal isschmia by the effect of nephrotoxic agent. The cellular lesion might be revercible. It might be accomparied with complete renal function and might be irreversible, therefore it may lead to renal cortical necrosis. In addition to usual reasons of acute failure , some of them relates specifically to pregnancy. Only infectious, criminal abortions and malignant vomiting are reasons of failure in the beginning of pregnancy, which severe pre-eclampsy, placenta and placenta abruption are the main reasons of renal failure in the final phase of pregnancy.
Shadan Pedram Razi, Zahra Haji Habibzadeh,
Volume 1, Issue 3 (Summer 1997)
Abstract
The purpose of this study is to determine the risk factors of back pain involved patients who come to orthopedic clinics. Findings demonstrated that factors such as age, weight, abdominal circumference, parity, exercise and posture related to back pain in both groups.
Mahmoud Pedram , Mohammad Taha Jalali , Fazlolah Ahmadi Esfahani,
Volume 1, Issue 5 (Winter 1997)
Abstract
Serum concentration of lipoprotein(a) is a genetically determined. Independent risk factor for coronary artery disease. Different studies suggest a possible role for a antioxidant and free radicals in the rate of lipoprotein (a) synthesis. Patients suffering from chronic renal failure (CRF) are known to be less guarded against oxidative products in comparison with normal population. In order to investigate the pattern of lipoprotein (a) serum concentration in CRF group, 87 number of patients undergoing supportive hemodialysis was selected and their Lp(a) serum concentration were compared with a control group (n=100). The result shows a significant elevation of LP(a) serum concentration in the patients in comparison with the control group (p,0.05).
Khadijeh Arjmandi Rafsanjani, Ali Chehrei, Majid Chalian, Shayan Shojaei, Ali Fahimi, Pedram Golnary,
Volume 5, Issue 3 (Autumn 2002)
Abstract
Introduction: Wilms' tumor is the most common malignant and primary renal tumor in children. Studies, which have been done in some countries, have introduced numerous factors such as age of incidence, stage, lymphadenopathy, histopathology and etc. Effective in the survival rate of this tumor according to the importance of this tumor in children, we decided to perform a study about the survival rate of Wilms' tumor and the effective factors on it.
Materials and methods: This is an analytic study on 128 patients affected with Wilms' tumor whom referred to the oncology ward of Hazrat-e-Ali Asghar Hospital between 1977 and 2001. In addition to the current status of the patients, demographic characteristics, signs and symptoms, laboratory studies at the time of diagnosis and the stage of the disease were recorded and ultimately survival analysis was performed using the Kaplan-Meier procedure and life table. Cox Regression was used to determine the effective factors.
Results: The mean survival rate was 82.99 months. The number of patients was equal in both genders (64 patients in each gender) and the survival average did not have any significant statistical relationship with gender (power=%92.4). Most of the tumors were in stage 3 at the time of diagnosis. The survival of the patients was reducing significantly with the progression of the stage of tumor (P=0.002). The existence of metastasis (P=0.000, odds ratio=0.207), splenomegaly (P=0.018, odds ratio=0.336), and recurrent (P=0.037, odds ratio=0.184), were significantly reducing the survival of the patient. To determine the severity of effective factors on the survival rate of the patients Cox Regression Method was used in which, absence of metastasis and positive blood group were from well-prognosis predictive factors in these patients.
Conclusion: 5-year survival rate of the patients was 63.28% in this study. Which was lower in comparison with the results of other studies in other countries. This can be the result of delay in consulting with medical centers, the diagnosis method and or the Referral State of this center. Recent studies have shown that age and tumor size has minimal values in the prognosis of the patients due to improvement in the quality of treatment and our study support this idea. Genetic factors will probably be used in determining the survival of these patients and also in thcir treatment.
Pedrama Ariapanah, Morteza Sattari, Zahra Jafari-Azar, Adonis Poormohammadi Mojaveri,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Due to problems caused by traditional dressings, scientists have long been in search for producing alternative cellulose. Unique characteristics of bacterial cellulose synthesized by acetobacter xylinum, due to its nanostructure cellulose, resulted in attempts to devise an ideal dressing with this cellulose. The main aim of this study is to evaluate the effect of impregnated bacterial cellulose on staphylococcus aureus culture. Materials and Methods: In this descriptive-analytical study, cellulose disks synthesized by bacterial cellulose and cellulose blank disks (without antibiotic) were placed in 3.3% ciprofloxacin hydrochloride. These disks were, then, together with ciprofloxacin standard, control cellulose, and cellulose blank disks, placed on the cultured media of staphylococcus aureus. After 24 hours, the results were obtained through the measurement of growth inhibition zone. Determining the amount of antibiotic absorbed into bacterial cellulose can be done through the comparison of the effects of cellulose disks containing different concentrations of ciprofloxacin hydrochloride and ciprofloxacin standard disks. Results: Both cellulose and blank disks created a growth inhibition zone in staphylococcus aureus media, whereas the growth inhibition zone of cellulose and cellulose blank disks (negative control) were insignificant. Conclusion: Noticing the unique characteristics of bacterial cellulose as a dressing and its proven ability in absorption and release of ciprofloxacin hydrochloride, the prospects are seen for production of antibiotics containing dressings of this microbial product in future.
Adonis Poormohammadi Mojaveri, Morteza Sattari, Zahra Jafari-Azar, Alireza Ghaffari, Pedram Ariapanah,
Volume 14, Issue 3 (7-2011)
Abstract
Background: Bacterial cellulose synthesized by acetobacter xylinum is a harmless microbial product with unique characteristics as an ideal dress that many studies have been done on. The aim of this study was to consider the capability of this product in absorption and release of tetracycline hydrochloride. Indication of this capability can pave the way for supplying a new dressing containing antibiotic from bacterial cellulose.
Materials and Methods: In this experimental study, cellulose sheet was initially impregnated on aqueous solution of tetracycline hydrochloride. Then the release process was considered in diluted water and normal saline. Ultra violet spectrophotometry method was applied to the detection of the antibiotic during absorption and release processes.
Results: The results of data analysis demonstrated that bacterial cellulose has a great potential in absorption of tetracycline hydrochloride and can release it in a wet environment.
Conclusion: Considering the advantages of bacterial cellulose over traditional dressings, the results of this study can provide the ground for further research on supplying an ideal dressing containing antibiotic from this microbial product.
Seyed Reza Mohebbi, Hamed Naghoosi, Pedram Azimzadeh, Shaghayegh Derakhshani, Afsaneh Sharifian, Mohammad Reza Zali,
Volume 18, Issue 7 (10-2015)
Abstract
Background: In spite of designing and applying an effective vaccine against Hepatitis B virus (HBV), chronic infection with this virus is still one of the most important health problems worldwide. Host genetic background including single nucleotide polymorphisms play a significant role in chronicity or clearance of the infection. The final product of programmed cell death 1 gene (PDCD1) is expressed frequently on T-cells and in chronic viral infections, prevent the virus-specific T-cell response against the virus. In this study, the association of a single nucleotide polymorphism (+7146A/G) in intron 4 of PD1 gene with chronic hepatitis B infection in Iranian population has been assessed.
Materials and Methods: 212 chronic HBV patients and 208 healthy controls were analyzed in this case-control study. Genomic DNA of the studied individuals was extracted and after performing polymerase chain reaction (PCR), polymorphism of +7146 was determined via RFLP method.
Results: Frequencies of GG, GA and AA genotypes on position 7146 of the intron 4 of PD1 gene were 77.4%, 20.7% and 1.9% in patient group and 80.8%, 15.4% and 3.8% in control group, respectively. After statistical analysis, No significant difference was observed between patient and control groups (p=0.198).
Conclusion: Genotype frequencies in the studied population are in accordance with the results of previous studies. Results of the present study suggest that there is not any association between A/G single nucleotide polymorphism in intron 4 of PD1 gene and susceptibility to chronic hepatitis B in Iranian population.
Mojtaba Salehi, Seyed Reza Mohebbi, Mehrdad Ravanshad, Maryam Karkhane, Pedram Azimzadeh, Behta Keshavarz Pakseresht,
Volume 18, Issue 12 (3-2016)
Abstract
Background: Hepatitis B virus (HBV) is a member of hepadenaviridae family, which is infectious for humans and a few animal species. Successful clearance and elimination of infection from the body or development of HBV infection to chronic disease depend on the host genetic background in immune system genes. Interleukin-12 (IL12) and also Interleukin-12 Receptor B1 (IL 12 RB1) are the key factors in the spontaneous clearance of viral infections, especially HBV. The aim of the present research is to investigate the association between Interleukin-12 receptor B1 gene polymorphism (rs11575934 A/G) and susceptibility to chronic Hepatitis B virus infection.
Materials and Methods: In this case-control study, genomic DNA of 150 chronic HBV infected patients and 150 healthy controls were extracted from peripheral blood cells. Single nucleotide polymorphism (rs11575934 A/G) was genotyped using polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).
Results: The frequency of GG, AG, AA genotypes was 6.7%, 40.7%, and 52.7% in chronic patients and 12.7%, 41.3%, and 46% in control group, respectively. No statistically significant difference between case and control groups has been observed (p=0.176).
Conclusion: In the present study, no significant correlation between rs11575934 A/G single nucleotide polymorphism of the IL12RB1 gene and susceptibility to chronic hepatitis B virus infection has been observed. According to the study, this polymorphism does not affect the susceptibility to chronic HBV infection.
Sara Pouriamanesh, Ziba Kamalian, Pedram Shafaat, Mona Amin Bidokhti, Nasser Salsabili, Reza Mirfakhraei,
Volume 19, Issue 6 (9-2016)
Abstract
Background: Azoospermia is defined as the absence of sperm in the semen and is divided in two types; obstructive and non-obstructive azoospermia. Non-obstructive azoospermia include approximately 60% of azoospermia patients. Several genetic and environmental factors can be involved in the development of non-obstructive azoospermia. Until now, several genes have been introduced as the causing factor of the azoospermia that are involved in spermatogenesis and testicular development. These genes are located on Y and/or autosome chromosomes .The aim of the present study was to investigate Y chromosome microdeletions and STAG3 gene mutations in Iranian males with non-obstructive azoospermia.
Materials and Methods: In this study, peripheral blood samples were obtained from 122 men with idiopathic non-obstructive azoospermia and 100 Normo-sperm men who had at least one child and DNA was extracted. Samples were investigated for the presence of Y chromosome microdeletions by Multiplex PCR. Then, existence of probable mutations in exon 7 of STAG3 gene was investigated using MSSCP (multi-temperature single-strand conformational polymorphism) method.
Results: 13 patients (10.66%) had Y chromosome microdeletions, but none of the subjects showed mutation in exon 7 of STAG3 gene. The Y chromosome microdeletions were found in none of the control individuals.
Conclusion: The results showed that Y chromosome microdeletions are the most important cause of non-obstructive azoospermia and should be considered as the main candidate for male infertility diagnostic tests. Mutations in the STAG3 gene are not common among non-obstructive azoospermia patients.
Hosna Rastegarpouyani, Seyed Masoud Hosseini, Seyed Reza Mohebbi, Pedram Azimzadeh, Shabnam Kazemian, Mahsa Saeedi Niasar, Afsaneh Sharifian, Mohammad Reza Zali,
Volume 20, Issue 2 (5-2017)
Abstract
Background: Parvovirus 4 (PARV4) was first discovered in 2005, in a hepatitis B virus–infected injecting drug user (IDU). To date, the best evidence about PARV4 transmission is parenteral roots and comes from IDU individuals. It seems that the prevalence of the virus in the normal population is very low. In this study, we investigated the prevalence of PARV4 virus among patients with chronic HCV infection compared with healthy controls and related risk factors among these groups.
Materials and Methods: A total of 206 patients, including 103 patients with chronic HCV infection and 103 healthy controls, were studied by use of nested-PCR and also real-time PCR techniques.
Results: AST enzyme levels with a mean of 40.45+34.84 and 18.58+5.9 in patients and healthy group respectively and the amount of enzyme ALT among patients with a mean of 40.45+35.75 and 21.50+11.35 in patients and healthy group respectively, were reported. Finally, after screening all DNA samples from patients and controls, we discovered that none of these people are infected with the PARV4 virus.
Conclusion: This study is the first to investigate the occurrence of PARV4 among HCV patients in Iran. The results show that, the virus is not important in Iranian population, even in patients with blood born infections such as HCV and further studies in other areas and various groups are required.
Pedram Pouryari Biyachal, Najmeh Ranji, Ali Nazemi,
Volume 24, Issue 1 (April & May 2021)
Abstract
Background and Aim: Non-syndromic hearing loss is a genetically heterogeneous disorder. Mutation in the GJB2 gene is a major cause of non-syndromic hearing loss in numerous countries. This study aimed to evaluate GJB2 mutations in 31 individuals with non-syndromic hearing loss
Methods & Materials: In this descriptive cross-sectional study, the required blood samples were collected from 31 individuals with non-syndromic hearing loss in Rasht and Bandar Anzali Cities, Gilan Province, Iran. After DNA isolation, the GJB2 gene was amplified by the PCR method and underwent sequencing.
Ethical Considerations:This study was approved by the Ethics Committee of the Islamic Azad University, Mashhad Branch (Code: IR.IAU.MSHD.REC.1398.027).
Results: In this study, 3 mutations were determined in 18 individuals with hearing loss. Accordingly, 35delG mutation had the highest frequency (48.38%) in individuals with hearing loss as homozygote (n=14) and heterozygote (n=2). A patient with heterozygosity in V153I mutation and a patient with compound heterozygosity in 35delG/G200R mutation was determined.
Conclusion: It appears that 35delG mutation is a common mutation in the GJB2 gene in individuals with non-syndromic hearing loss in Guilan Province.
