Shirin Pazouki,
Volume 3, Issue 1 (Spring 2000)
Abstract
Through a clinical trail, the effects of metoclopramide infusion compared with a placebo in order to assess the effectiveness of the medicine in Imam Khomeini and Vali-Asr hospitals of Tehran were brought under consideration in two groups, which passessed the necessary condition. Metoclopramide was prescribed as a bolus dose of 0.5m/Kg and then its infusion as 1m/Kg at 6 hours intervals, while the control group were only received normal saline for the same duration. Sampling was simple and there was no distinctions between the groups. In review of the postoperative pain the patients were precisely looked after for the next 24 hours of the operation by the ward nurses and if it necessitated narcotics were prescribed. The analysis of the results manifested that the metoclopramide infusion doesn’t lessen the necessity of using narcotics significantly (P=0.174), but it can increase the analgesic effect of narcotics in case group compared with the control group. (P=0.0344) and the intervals of needing narcotics have been more (P=0.0223). In addition, the control group had considerably less incidence of nausea comparing with case group (P=0.0094) and the degree of vomiting was nearly less too (P=0.157). The sedation degree was significantly higher than the case group (P=0.033). No any other side effects of narcotics or metoclopramide, including itching, restlessness and tremor were observed. Metoclopramide infusion can increase the analgestic effects of narcotics. Drugs and significantly lessens the need for narcotics during the first hours of postoperation, Moreover it reduces the incidence problems arising from the site of incision and prescription of narcotics with high dose can be dangerous.
Shirin Pazouki, Mehri Eskandari, Sare Memari, Afsane Norouzi, Afsane Zargangfar,
Volume 9, Issue 3 (9-2006)
Abstract
Introduction: Spinal anesthesia is a conventional way of anesthesia for cesarean section (CS), which nausea and vomiting is a common complication of it. Metoclopramide is the standard medication used for preventing intraoperative nausea and vomiting (IONV). Because of extrapyromidal side effects of Metoclopramide and known antiemetic effects of low-dose Propofol and Dexamethasone, this study was performed to compare the effectiveness of these drugs for preventing IONV. Materials and Methods: This study, is a randomized clinical trial which is done on 144 parturients who were admitted for emergency CS. Patients were divided randomly into four groups and received: Metoclopramide 0.1 mg/kg IV, Dexamethasone 150 g/kg IV, Propofol 0.1mg/kg every 5 minutes from clamping umbilical cord till the end of operation and the fourth group received 2 ml distilled water. During the operation parturients were monitored for IONV. Data was analyzed using Kruskal-Wallis and one way ANOVA. Results: The Number of patients having nausea was lowest in Propofol and highest in Dexamethasone group. There was no statistical significant difference between Dexamethasone and placebo groups. The lowest rate of vomiting was in Metoclopramide and Propofol groups and there was no significant difference between them. Also the lowest level of retching was in the Prepofol group. Conclusion: According to results, the antiemetic effects of Propofol and Metoclopramide are similar. Amount of retching in Propofol was slightly lower than Metoclopramide and administration of Propofol was simple, cheap and without serious complications, so we recommend it for emergency CS.
