Showing 3 results for Pazhoohan
Abbas Alimoradian, Saeed Pazhoohan, Omid Mirzabeygi, Kiana Naderinia,
Volume 23, Issue 6 (February & March 2020)
Abstract
Background and Aim: Opioid and benzodiazepine family drugs are concurrently used in various patients. Considering the respiratory depressant effects of both classes, in this study, we investigated the effect of coadministration of morphine and several widely used benzodiazepines in the clinic on the rate of respiratory depression in rats.
Methods & Materials: Seventy adult male Wistar rats were randomly divided into 10 groups; morphine, midazolam, diazepam, lorazepam, alprazolam, morphine-midazolam, morphine-diazepam, morphine-lorazepam, and morphine-alprazolam. Respiration signal was recorded using whole-body plethysmography 15 minutes after the intraperitoneal injection of the drugs. The respiratory pattern was examined using several parameters; the mean value of inter-breath interval and the respiratory rate, as well as the coefficient of variation and sample entropy analysis of inter-breath interval.
Ethical Considerations: This study was approved by the Ethics Committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1397.327).
Results: Analyzing respiratory data revealed that injecting the anxiolytic dose of alprazolam, and the combination of morphine-alprazolam and morphine-midazolam, altered the respiratory pattern. Such changes were associated with a decrease in the number of breaths and an increase in the inter-breath interval in the explored test animals, compared with the controls. The obtained data also indicated that morphine-midazolam injection increased the variability of the breathing pattern; such an alternation was associated with increased irregularity and decreased coefficient of variation of the inter-breath interval.
Conclusion: The present research results suggested that the short-term injection of morphine-midazolam changes the respiratory pattern more severely than morphine combined with other benzodiazepines.
Masoumeh Gholami, Mr Hossein Bakhtiari-Dovvombaygi, Miss Mahla Rezaei–shandiz, Dr Saeed Pazhoohan, Mehdi Sadegh,
Volume 26, Issue 3 (August & September 2023)
Abstract
Introduction: Maternal folate supplementation during pregnancy is associated with reduced risk of several fetal neurodevelopmental disorders. However, it is not well known that excess folate intake from diet and supplements can impair neurodevelopment and behavior in offspring. Therefore, the aim of this study is to investigate the effect of chronic and high doses of folic acid before and during pregnancy in female rats on learning and spatial and avoidance memory in male and female offspring.
Methods: 24 female Wistar rats received doses of 0.5, 1, and 2 mg folic acid by intraperitoneal injection two weeks before and during pregnancy. The control group received normal saline. Male and female offspring were divided into 8 groups. Learning behavior and spatial memory were measured by Morris blue maze test, avoidance memory by shuttle box test. The results showed that taking a dose of 2 mg folic acid before and during pregnancy causes spatial learning deficits in male offspring.
Results: While spatial memory is unchanged compared to the control. This dose of folic acid also causes a disturbance in avoidance memory in both male and female offspring.
Conclusions: Our results suggest that high doses of folic acid supplements during early life (fetal) have the potential to impair neurological functions such as memory. Although the severity of this disorder can depend on the gender of the child.
Saeed Pazhoohan, Fatemeh Abbasi Feijani, Abdollatif Moini , ,
Volume 26, Issue 6 (February & March 2024)
Abstract
Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating condition. People with COPD often experience exacerbations that may require hospitalization. Pattern analysis of respiratory variability can provide valuable insights into the complexity of the respiratory control system. Therefore, this study investigated respiratory pattern variability during stable and exacerbation phases in patients with COPD.
We analyzed respiratory signal data from 14 patients with COPD during exacerbations and stable phases and compared them with 12 age- and sex-matched control subjects. Respiratory pattern variability analysis of 30-minute inter-breath intervals (IBI) time series was performed using sample entropy and Detrended Fluctuation Analysis.
Sample entropy analysis of the IBI revealed that respiratory variability was more regular during both stable and exacerbation phases in patients with COPD. Also, the short-term (α1) and long-term fractal-like correlation (α2) significantly decreased during both exacerbation and stable phases compared to healthy controls.
The respiratory control system in patients with COPD shows less variability (lower entropy and fractal correlation). This reduction in respiratory signal variability indices in COPD patients is still lower than in healthy people, even when their disease status is stabilized.
