Showing 2 results for Pasalar
Akram Ranjbar, Parvin Pasalar, Ali Reza Sedighi , Mohammad Abdollahi , Jamileh Danesh-Nia ,
Volume 6, Issue 2 (Summer 2003)
Abstract
Introduction: Production of free radicals and reactive oxygen species is an integral part of aerobic metabolism. Disturbance of the balance between the production of free radicals and antioxidant system against them produces oxidative stress. Paraquat toxicity is induction of oxidative stress. However, the aim of our study was to evaluate oxidative stress in blood samples of workers in a pesticide factory formulating paraquat.
Materials and Methods: In this study we measured lipid peroxidation (LPO) with thiobarbituric assay (TBARS), total antioxident power (FRAP) and SH groups between workers in pesticide factories (case group) and health subjects (control group).
Results: Oxidative stress was significantly higher (p<0.001) in LPO, significantly lower (p<0.001) in TBARS and significantly lower (p<0.001) in SH groups in the case group compared to control group
Conclusion: It is concluded that chronic exposure of workers in their workplace to paraquat producess oxidative stress that could be prevented by well known nutritional antioxidant supplements.
Akram Ranjbar, Parvin Pasalar , Mohammad Abdollahi, Mostafa Delavar ,
Volume 7, Issue 2 (Summer 2004)
Abstract
Introduction: Oxidative stress is one of the factors producing poisoning during chronic exposure to organophpsphporous poisons. In this research we studied oxidative stress status and acetycholinesterase in pesticide manufacturing workers.
Materials and Methods: This is a cross-sectional analytical study in which 45 organophopsphorous (OP) formulating pesticide workers with a minimum work history of 1 year in the age range of 23-35 were studied. Controls were age–matched workers of a food-making factory. They were evaluated for oxidative stress markers, including Tthiobarbituric acid-reactive substances (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total Thiol (SH) groups and Gammaglutamyl transpeptidase (GGT) levels in blood and ACHE activity in erythrocytes.
Results: The results showed marked inhibition of ACHE, increased TBARS, decreased FRAP and decreased Thiol group level in workers. The reduction in activity of ACHE correlated well with increased TBARS and decreased FRAP in OP formualtors.
Conclusion: It is concluded that Op-formulating workers are exposed to more oxidative stress. The measurement of erythrocyte ACHE activity in pesticide workers who formulate Ops can be a good monitoring factor and is recommended to be performed in a regular manner.
