Showing 32 results for Parvin
Mohammad Hassan Mohammadi, Parvin Ghal-E Riz , Saeed Pahlevanzadeh, Gholam Abass Mosavi , Masoumeh Hamzeei ,
Volume 4, Issue 1 (Spring 2001)
Abstract
Diabetes is one of the important endocrine disease. In recent 10 years it has increased to 70 million people in the world. The diabetes patients are aware of that complications may occure in future. Depression is the most common one. This study is a descriptive-analytic which was done in 1999 in Kashan diabetes center. The aim of this research was to determine the incidence and severity of depression in the diabetic patients who were used to take antidiabetic tablets and insulin. For this purpose, the researchers selected 80 diabetic patients to have characteristics to enter the study. (38 patients were treated by tablets and 42 patients by insulin). Method of sampling was conclude one data were gathered with Beck test and two part questionnaire including demographic and severity of depression in patients taking insulin. Severity of depression was higher than tablet users. On the other hand there was a significant relation between severity of depression and kind of treatment (insulin injection) (P<0.04). Regarding to the findings, however depression in these patients is high and the patients who are taking insulin are at risk of this mental complication and the health team members should take care of them.
Fereydoun Azizi, Robabeh Sheikholeslam, Parvin Mirmiran, Gita Abdolhosini, Masoud Kimiagar, Hossein Malekafzali,
Volume 4, Issue 3 (Autumn 2001)
Abstract
Introduction: Iodine deficiency disorders (IDD) is a worldwide health problem. Many parts of the Islamic republic of Iran had been known as areas of endemic goiter. IDD was accepted as a priority health problem in the country and a National IDD Council was formed in 1989.
Material and Method: One of the main strategies of National Council for IDD control was to provide at least 150mg of iodine per day to the entire population through making available iodized salt. This study was performed to evaluate the National IDD council program in 1996, in rural and urban areas of Markazi province, 1300 school children, aged 8 to 10 years, including 50% boys, were selected through random sampling Grading of goiter was performed according to WHO. Classification, Serume, T3, T4 and TSH were measured by RIA and urinary iodine by digestion method.
Results: The mean of serume T3, T4 and TSH were: 10±2.0 μg/dl, 160±28 ng/dl and 2.3±1.3 μIu/ml respectively. There were no differences between males and females and school children of rural or urban areas. Four person had serum T4 more than 12.5μg/dl. The mean urinary iodine was 16mg/dl in entire population. 75% had urinary iodine more than 10mg/dl. Only 11% had urinary iodine less than 5μg/dl. Total prevalence of goiter was 35% (36% in girls and 34% in boys).
Conclusion: Based on the available data, seven years after distribution of iodized salt, urinary iodine of school children of Markazi province does not show iodine deficiency. However goiter is still endemic in Markazi province.
Akram Bayati, Parvin Abasi,
Volume 5, Issue 1 (Spring 2002)
Abstract
Introduction: This research is a study for evaluating the rate of satisfaction of physical and psychosocial needs of thirds girl students of secondary school of Arak by their parents.
Materials and Methods: In this research 556 girl adolescents were studied. Sample were selected by clustering method. Data were collected by questionnaire (contain 57 question) completed by studied units. After collect the data , results were analyzed by statistical methods.
Results: 69.1% samples were high satisfied, 29.3% medium and 1.6^ low satisfied in relation to physical needs by their parents and 69.6% were high satisfied, 28.2% medium and 2.2% low satisfied in relation to psychosocial needs by their parents. The rate of satisfaction for physical needs is statistically correlated to the variable such as age of the students (p<0.05), age of the mother (p=0.03), age of the father (p=0.0001), education levels of the parents (p=0.0001), job of the father (p=0.0001), job of the mother (P=0.0007), rank of birth (p=0.008) and total children of the family (p=0.0001). Results of the research shoed that rates of satisfactions for psychosocial needs of the samples have a meaningful correlation with variables such as age of the student (p=0.003), education levels of the mother (p=0.0001), job of the parents (p=0.0007) and total children of the family (p=0.0001).
Conclusion: Finally the result of this research indicates that families economic disorders affects cause an important role against in sufficiency of psychosocial needs in adolescents. Therefore it should be suggested to perform a more developed study about the above subject in order to obtain the most accurate conclusion.
Parvin Abasi , Susan Heidarpoor, Behjat Afkari, Mansour Rezaeei, Shirin Iranfar, Katayoon Esmaeeli,
Volume 5, Issue 3 (Autumn 2002)
Abstract
Introduction: Regarding the extensive use of IUD, as contraception. The present study was conduced to evaluate the complications resulting from muliload 375 and T Cu 380A IUD inserted in women referred to the health and treatment settings of Kermanshah medical sciences university in the year 2002.
Materials and Methods: The study was descriptive-analytic, on 122 women using M.L 375 IUD and 245 others using T 380A IUD were fully assessed. The tools used to collect data were questionnaires evaluating the following variables: Pregnancy, bleeding, ectopic pregnancy, uterine perforation, and expulsion, pelvic inflammation disease (PID). To analyze the data, descriptive statistic and X², student-T and Fisher tests were used.
Results: Severe bleeding during menstrual cycle was the most common complication in the two study groups, especially in the multiload 375 IUD group (75% vs. 41.6%; P<0.001). The multiload 375 IUD had a significantly higher dysmenorrhea rate compared to the T cu 380A (%70.8 vs. %40.8; P<0.001). The rate of intera-uterine pregnancy was low for the two device %1.7 vs. %2, and occurrence of ectopic pregnancy in multiload 375 IUD was 0.8% and in T Cu 380A group was not reported. There was no uterine perforation observed for either device.
Conclusion: According to the results gained, the common complications in each group were not dangerous and their severe and threatening complications were uncommon. The most frequent complications were severe bleeding during menstrual period, dysmenorrhea and spotting which were not life threating and could be controlled by supporting and training their users, although these complications were seen more among those using M.L 375 IUD. These two device were effective enough to prevent pregnancy. It seems that using T Cu 380A IUD is more suitable for those who want to have a long-term contraception.
Akram Ranjbar, Parvin Pasalar, Ali Reza Sedighi , Mohammad Abdollahi , Jamileh Danesh-Nia ,
Volume 6, Issue 2 (Summer 2003)
Abstract
Introduction: Production of free radicals and reactive oxygen species is an integral part of aerobic metabolism. Disturbance of the balance between the production of free radicals and antioxidant system against them produces oxidative stress. Paraquat toxicity is induction of oxidative stress. However, the aim of our study was to evaluate oxidative stress in blood samples of workers in a pesticide factory formulating paraquat.
Materials and Methods: In this study we measured lipid peroxidation (LPO) with thiobarbituric assay (TBARS), total antioxident power (FRAP) and SH groups between workers in pesticide factories (case group) and health subjects (control group).
Results: Oxidative stress was significantly higher (p<0.001) in LPO, significantly lower (p<0.001) in TBARS and significantly lower (p<0.001) in SH groups in the case group compared to control group
Conclusion: It is concluded that chronic exposure of workers in their workplace to paraquat producess oxidative stress that could be prevented by well known nutritional antioxidant supplements.
Shima Chehreie, Parvin Rostami, Jhla Bezady,
Volume 6, Issue 4 (Winter 2003)
Abstract
Introduction: stress in the natural reflection of living creatures against internal and external motivations while stress hormones are secretion through cardiovascular, every production, and security systems. Some stress producing factors are muscular activities, anesthetics, surgery, starvation, water deprivation, etc. Thus, we studied effect of prenatal water deprivation stress on hormone level and sexual dimorphic nucleus in male rats.
Materials and methods: In an experimental design, adult female and male Wistar rats (180 gr) acquired from Pastor institute and were coupled. Pregnant rats were divided randomly into control and experimental groups. Both groups were maintained under a controlled temperature (20±2°C) and photoperiod (13:11h, light: dark) conditions. Controlled group had food and water available ad lib, but experimental group had access to food and were deprived of water from the beginning of third week of pregnancy to the end of week. At 42 days at birth, male rats were slight anesthetic in order to prepare the blood and morphometric evaluations.
Results: Plasma testosterone average level in experimental group was less than controlled groups (p<0.001), while in the comparison between experimental and controlled groups, progesterone indicates significant increment (p<0.001). There is no statistically significant regarding Estradiol level between both groups. Historical study indicated that the decreased size and number of neurons of MPO and Sch nuclei were significant in experimental compared to controlled ones.
Conclusion: Prenatal water deprivation through affecting MPO and Sch nuclei, approximate inhibition of nuclei and decrease in secretion of Testosterone cause the emergence unusual sexual behavior and similar female sexual behaviors in male experimental rats in the postnatal and maturity. |
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Akram Ranjbar, Parvin Pasalar , Mohammad Abdollahi, Mostafa Delavar ,
Volume 7, Issue 2 (Summer 2004)
Abstract
Introduction: Oxidative stress is one of the factors producing poisoning during chronic exposure to organophpsphporous poisons. In this research we studied oxidative stress status and acetycholinesterase in pesticide manufacturing workers.
Materials and Methods: This is a cross-sectional analytical study in which 45 organophopsphorous (OP) formulating pesticide workers with a minimum work history of 1 year in the age range of 23-35 were studied. Controls were age–matched workers of a food-making factory. They were evaluated for oxidative stress markers, including Tthiobarbituric acid-reactive substances (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total Thiol (SH) groups and Gammaglutamyl transpeptidase (GGT) levels in blood and ACHE activity in erythrocytes.
Results: The results showed marked inhibition of ACHE, increased TBARS, decreased FRAP and decreased Thiol group level in workers. The reduction in activity of ACHE correlated well with increased TBARS and decreased FRAP in OP formualtors.
Conclusion: It is concluded that Op-formulating workers are exposed to more oxidative stress. The measurement of erythrocyte ACHE activity in pesticide workers who formulate Ops can be a good monitoring factor and is recommended to be performed in a regular manner.
Parvin Soltani, Fariba Asadi, Amir Sobhani,
Volume 8, Issue 1 (Spring 2005)
Abstract
Dr Ali Chehrei, Dr Manijeh Kahbazi, Dr Bahman Salehi, Dr Afsaneh Zarganj-Fard, Dr Fatemeh Darreh, Dr Parvin Soltani, Dr Ashraf Zamani, Dr Mohammad Khalili, Dr Afsaneh Noroozi,
Volume 9, Issue 2 (6-2006)
Abstract
Introduction: Performing correct research in different aspects of community as well as medical sciences can be a way to resolve many problems. In order to create a systematic knowledge of research method in academic members of Arak University of medical sciences and enabling them in providing proposals and performing researches, a clinical research center was developed. This study is done to investigate the effect of this center on improving clinical researches in the University. Materials and methods: This is a HSR, before and after, interventional study in which, clinical academic members of Arak University of medical science were evaluated. First the information of the pre intervention period was gathered (jan2002-jan2004). Then the intervention was done in the form of developing a research center in Vali-Asr hospital, performing serial research workshops, research conferences, research consultations and planning data bases during a 2 years period. Again data was gathered and then compared to those of pre intervention period. Results: The comparison of pre and post intervention periods showed that in pre intervention period from 38 proposals 30 and in post intervention period from 89 proposals 76 were approved by research committee of the University. In the two pre and post intervention periods 14(46.6%) and 50(65.8%) of accepted proposals were clinical respectively. Also from the view point of quality, 11 and 15 proposals were HSR, 2 and 22 clinical trials and 8 and 8 descriptive, respectively. The number of published articles in first period was 45 and in second 84. Presented articles in internal and external congresses were 33 and 59 in the two periods overally, which 25 and 51 articles were presented in the country and 8 and 8 in abroad congresses, respectively. Conclusion: Regarding the results it seems developing research center in this University and other similar Universities can have a significant effect on the process of clinical researches.
Nasud Nazem, Parvin Sajedi, Vahid Goharian, Mohamadreza Shirvani,
Volume 9, Issue 3 (9-2006)
Abstract
Introduction: Using one subcutaneous infiltration of Bopivacaine can cause a good pain relief in pediatric surgery, so the child may no longer need rectal Acetaminophen after surgery. In this study, we compared the efficacy of the two drugs. Materials and Methods: This was a clinical trial, performed on 141 pediatric patients between 6 months to 3 years old with unilateral or bilateral inguinal hernia or undescending testis. Patients were divided randomly into two groups. The first group received infiltration of Bopivacaine preoperatively and the second received the routine rectal Acetaminophen after surgery. In both groups pain score was measured with FPRS score 3,6,12 and 24 hours after surgery. After collecting data they were analyzed with T-student and Friedman tests. P<0/05 was considered significant. Results: Global FPRS pain score was lower in the group treated with Bupivacaine infiltration on 3 and 6 hours after surgery (p<0/05), but in 12 and 24 hours after surgery no significant difference was seen in the two groups. Conclusion: This study showed that, infiltration of Bupivacaine reduces pain better than Acetaminophen, especially during the first 6 hours after surgery. So because of better pain control and also single administration, we suggest using infiltralition of Bupivacaine preoperatively.
Parvin Mahzouni, Nadia Taheri, Maryam Taravat, Azar Danesh,
Volume 9, Issue 3 (9-2006)
Abstract
Introduction: Adenosarcoma is a rare uterine tumor composed of benign epithelial and malignant stromal elements. In 20% of cases stroma contains heterologous elements (usually from stratified muscle type). Association between Tamoxifen usage (exogenous strogen) or ovarian thecoma (endogenous strogen) and occurance of this tumor has been reported. This is a case report of a uterine Adenosarcoma. Case: The patient was a 45 years old woman with history of 16 years OCP use who was admitted with a uterine mass and undergone total hysterectomy. Microscopic assessment of slides, stained by H&A, was indicator of Adenosarcoma with cartilage heterologous elements. Conclusion: Uterine Adenosarcoma is a rare tumor. Although there is a few reports of cartilage heterologous elements in uterine Adenosarcoma, this case had multiple cartilage points in stroma. Also in this case, the coexistance of this tumor with long- term OCP use was considerable.
Soleiman Zand, Hadi Hasan-Khani, Parvin Soltani,
Volume 10, Issue 1 (3-2007)
Abstract
Introduction: End stage renal disease (ESRD) is a major health problem and each year the number of patients is increasing. If the disease becomes irreversible, patients must always be hemodialyzed. Since mortality rate will increase due to inadequate dialysis, determining the efficacy of hemodialysis and improving its quality is very important. The main goal of this research is investigating the efficiency of hemodialysis. Materials and Methods: This is a cross-sectional analytical study which was conducted on 103 people who were under dialysis treatment in the Vali-e-Asr hospital of Arak in year 2003. Weight, blood pressure (before and after dialyze), time of dialysis, BUN and Cr before dialysis and 5 minutes after turning of the pump and before the second dialysis were measured. Data was analyzed by T test and Pearson correlation. Results: The mean of KT/V was 0.58 ± 0.1 normal protein catabolic rate (nPCR), 0.36 ± 0.11 g/kg per day and time average concentration of urea (TAC), 43.3 ± 14 mg/d which had a significant difference with standard measures (p<0.05). KT/V was 0.49 ± 0.18 and 0.47 ± 0.10 for men and women respectively which was significantly different (p<0.03). There was a positive and linear relationship between education level and TAC, KT/V and number of dialysis per week. Conclusion: Regarding the low efficiency of hemodialysis in 80% of patients and lower levels of hemodialysis efficacy indicators in comparison to standard measures, periodic assessment and also investigating the reasons of low efficacy of hemodialysis is recommended.
Parvin Zareian,
Volume 12, Issue 1 (5-2009)
Abstract
Background: The role of sex hormones in pain perception and the effect of stress on reproductive system have not been determined yet. The present study investigated the effects of acute and chronic restraint stress on nociception and sex hormones concentration in rats. Methods and Materials: This experimental study was carried out with 47 male and female rats which ranged in weight from 170-230 gr. In order to transmit stress to the rats, they were initially exposed to acute restraint stress (1h) and chronic stress (for two weeks-1h/day). Then they were submitted to tail flick test for nociception evaluation. Sex hormones serum level was measured by radioimmunoassay method. Results were analyzed with Mann-Whitney and Kruskal-Wallis tests. Results: In male and female rats, acute restraint stress had significant increment in latency in the tail flick test. Chronically stress in male rats, was not significant effect on latency time. Chronically stress in females responded to restraint stress with an increase in tail flick latency. Both acute and chronic restraint stress reduced testosterone level in the male rats. In the female rats, only acute restraint stress significantly decrease plasma estradiol level. Restraint stress did not effect on testosterone concentration level in the female and estradiol level in the male rats. Conclusion: Acute restrain stress decrease nociceptive and sex hormon levels in male and female rate but, chronic restraint stress causes sex dependent response.
Alireza Ghorbani Birgani, Parvin Abedi, Kourosh Zare, Saeed Assadpoor,
Volume 15, Issue 8 (January 2013)
Abstract
Background: Psoriasis is a common chronic skin disease which usually appears as white and silvery spots on the skin. The purpose of this study is to investigate the effect of berberine on patients with psoriasis. Materials and Methods: This double-blind clinical trial was conducted on 60 psoriasis patients who referred to Imam Khomeini Hospital, Ahvaz, between July and December 2011. The patients were randomly divided into two equal groups that applied berberine and placebo to the treatment of their lesions twice a day. Lesions severity rate in the patients was assessed 7 times using a Psoriasis Area Severity Index (PASI). Data were analyzed by ANOVA with repeated measurements and Chi-square using SPSS software. Results: After 6 months, severity of lesions showed a significant decrease in the group receiving the berberine cream compared with the placebo group so that the mean PASI score of the group receiving berberine decreased from 3.99 to 2.11 while in the placebo group this decreased from 3.98 to 3.71. Mean difference in PASI score was not significant before receiving the treatment till the third month in berberine and placebo groups, but in the fourth to sixth months it was statistically significant (p=0.013). Conclusion: Berberine cream was more effective than the placebo in reduction of skin lesions of psoriasis patients. Therefore, it is recommended that plant-based drugs, like berberine, be used more besides the main medications of patients.
Mitra Tadayon Najafabadi, Zahra Shalikar, Parvin Adedi, Zahra Bamshad,
Volume 16, Issue 1 (4-2013)
Abstract
Background: Depression is one of the most commonly observed problems in menopausal women. This study was conducted to determine the effect of omega-3 fatty acids on menopausal depression in women referring to No. 1 Health Clinic of Ahvaz, Iran, in 2010.
Materials and Methods: This randomized double-blind clinical trial was done on 70 menopausal women experiencing various levels of depression. After administering the Hamilton Depression Rating Scale (HAM-D-21), the participants who met the inclusion criteria were randomly divided into intervention group (n=35) receiving a 2gr omega-3 capsules and control group (n=35) receiving 2 gr placebo capsules. After 8 weeks of intervention, data were collected and analyzed by Chi-square, independent t-test, and one-way ANOVA with repeated measures using SPSS software version 17.
Results: Mean depression scores decreased significantly (p<0.001) in the intervention group (13.36±2.23 to 8.72±3.71). Also, mean depression scores decreased (p>0.05) in the control group (13.25±2.04 to 11.78±2.93) however, it was not significant. The comparison of depression scores did not indicate a significant difference regarding the reduction of depression after intervention between the two groups (p=0.08).
Conclusion: According to the findings of this study, administration of omega-3 capsules (2gr/daily) for 8 weeks decreased menopausal depression. However, there was not a significant difference between omga-3 and placebo groups in this study. For a more precise observation of the effects, further studies with longer periods of intervention are needed.
Ali Khajehlandi, Hosein Jafarei, Amin Mohammadi Demieh, Parvin Barzideh,
Volume 16, Issue 5 (8-2013)
Abstract
Background: Heat shock proteins (HSP) are from proteins family playing crucial role in maintaining cellular hemostats and protecting cells in an acute and chronic stressful conditions. The object of this study is to investigate the alternation of heat shock proteins (HSP70) levels after Wingate and Strand tests in female students.
Materials and Methods: In this semi- experimental study, 40 female (20 athletics and 20 non-athletics) with the mean age 22.3±3 & 23.2±2, Height 159.2±5 & 161.2±4 cm and mean weight of 59.3±3 & 65.4±2 kg (respectively) were selected randomly and underwent training protocols of Wingate and Strand tests with 3 days intervals. 5 cc brachial vein blood samples were taken immediately before and after performing tests in order to analyze the data using repeated measure method.
Results: The findings showed significant increase after aerobic Strand test between athletics and non-athletics Female (p<0.01). But, after aerobic Wingate test, a significant increased was observed only in Athletes' group (p>0.05). But there was an insignificant reduction in non-athlete group.
Conclusion: The results showed that exercise duration is more important than exercise intensity in HSP70 production.
Saeid Babaei, Reza Talebi, Mohammad Reza Darabi, Mahmood Reza Nakhaei, Mohammad Bayat, Parvindokht Bayat, Maryam Ba Azm,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Pentoxifylline is a xantin derivative that causes deduction of blood viscosity, improves peripheral blood current and increases tissues oxygenization. In this study, considering special properties of this drug and inspite of undefined mechanism of its effect, the effect of pentoxifylline on skin biomechanical indices in acute phase of skin wound healing in rat is evaluated.
Materials and Methods: In this experimental study 14 adult Wistar rat were divided in two groups of experimental (n=7) receiving 100mg/kg twice a day and control (n=7) receiving distilled water intraperitoneal. Incisional wounds, 20mm length in identical pattern were created on back skin of rats. On day 15 skin strips containing incision were excised and used to evaluate biomechanical indices, work up to maximum force-Nm and Tensile strength= Rm-N/mm2. Results were analyzed by Spss soft ware and K-S, Levens and student T-Test.
Results: According to biomechanical test findings, pentoxifylline administration causes improvement in biomechanical indices of skin after 15 days of drug administration. Discrepancy between skin biomechanical indices of experimental and control subgroups was significant (p<0.05).
Conclusion: Pentoxifylline caused improvement in skin biomechanical indices and accelerated skin wound healing in experimentals.
Bahram Pourghassem Gargari, Parvin Dehghan, Elham Mirtaheri, Zeynab Faghfouri, Pouran Karimi,
Volume 16, Issue 8 (11-2013)
Abstract
Background: Considering the high prevalence of diabetes and developing cardiovascular diseases via dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of Oligofructose-enriched inulin on serum lipid concentrations and inflammation in type2 diabetic patients.
Materials and Methods: In this clinical trial, 52 patients with type 2 diabetes were assigned to one of two groups. Experimental group (n=27) received 10g/d oligofructose-enriched inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, hs-CRP and serum lipids concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables.
Results: At the end of study, we observed significant decrease in total cholesterol (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.7%), TC/HDL-c ratio (-0.73, 20.7%) and LDL-c/HDL-c ratio (-0.55, 27.5%) in oligofructose-enriched inulin compared with the maltodextrin group (p<0.05). Changes in concentrations of triglycerides and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group.
Conclusion: Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications.
Ali Akbar Raygani Visi , Mahnaz Ahmadi, Mansour Rezae, Behzad Haydarpour, Parvin Taghizadeh,
Volume 16, Issue 12 (3-2014)
Abstract
Background: Cotonary artery illneses are the common heart illness that there is treatment methods now, many patients need the coronary artery bypass graft. Anxiety is a common phenomenon after all surgical operation. Anxiety in coronary artery bypass graft causes to increase metabolic rate, decrease immunity of body, and increases activity of heart coronary and gastrointestinal. This study was perfound to assess the effects of metatarsus foot reflexology on state anxiety levels after coronary artery bypass graft in Imam Ali Hospital Kermanshah.
Methods and Materials: This clinical trial included 88 patients that they were divided in to the intervention and control group based on the randomly. The intervention group received a 10 minute right foot massage one day on third and fourth day after coronary artery bypass graft and control group received no intervention, only at the time mentioned, score anxiety was measured with standard questionnaire spielberger.
Results: Patients state anxiety significanty decreased in the intervention group in the third day comparison with the control group, but no difference were not observed in the control group.
Conclusion: The finding of the study showed foot reflexology to be effective and simple that complication and damages are low that is used in reducing patients anxiety in treatment-health centers.
Pouran Karimi, Roshanak Bayat Makou, Parvin Dehghan, Mohamad Reza Salimi Movahed,
Volume 17, Issue 1 (4-2014)
Abstract
Background: Selenium is a unique trace element which is benefit on inflammatory underlining diseases. MAPK (Mitogen-activated protein kinase) pathways regulate several cellular functions including inflammation, cell differentiation, migration, and apoptosis. Objective: This study aimed to find out the pathway(s) by which Selenium modifies inflammatory events in oxidative or thrombotic induced stress in platelet.
Materials and Methods: This is a basic -experimental study on Human platelets obtained from 30 healthy individuals (age 35±12) .The phosphorylation rate of P38MAPK , c –JNK (c-Jun N-terminal Kinase), and ERK1/2(Extracellular signal-regulated kinases1/2) as three important proteins in MAPK family and P-selectin were measured in presence or absence of selenium by ELISA( solid phase sandwich Enzyme Linked-ImmunoSorbent Assay). Pharmacological inhibition is done by inhibitors of P38MAPK, ERK1/2 and c- JNK in order to compare with selenium effects. The percentage of ratio of phosphorylated to total protein was used for normalizing the phospho protein contents of platelets.
Results: Selenium significantly reduced P-selectin expression (p<0.05), P38MAPK (p<0.05) and c- JNK phosphorylation (p<0.05) induced by cu2+oxidized LDL in platelets but Se couldn’t significantly reduce Thrombin induced P-selectin despite of decreasing in mentioned phospho-proeins.
Conclusion: Our results indicated that Selenium can reduce inflammation via suppression of p38MAPK-dependent signaling pathway. These results may provide insights related to development of novel Selenium therapies in atherosclerosis.
