Showing 2 results for Palizvzn
Mohamadreza Palizvzn, Ehsan Elah Ghaznavi Rad,
Volume 8, Issue 2 (7-2005)
Abstract
Introduction: Epilepsy is one of the most common afflictions of human. The amygdala is one of the most sensitive epilepsy induction areas. This area has been the focus of interest, in large part due to its role in fear conditioning. It seems that any abnormality in the neuronal network in amygdala can increase the susceptibility of animal to seizure. The purpose of the present study was to evaluate the relationship between avoidance learning and kindeling susceptibility in rats.
Materials and Methods: In an experimental study, 20 Wistar male rats were trained for two way active avoidance learning in the shuttle box, and on the basis of escape response were divided into fast and slow learning animals. The rats were administered Pentylenetetrazole for induction of kindeling. Then seizure stages were noted. Data was analyzed using one way ANOVA and Tukey's test.
Results: Results of the present study demonstrated that slow learning animals comparing to fast learnings were more prone to kindeling and there was a significant difference in the seizure stage and stage 2 latency in the two groups.
Conclusion: On the basis of the present data it is possible to predict the predisposing of male rats to kindeling from the rate of fear conditioning that indicates the abnormality in amygdala neuronal circuits
Mahmoudreza Palizvzn, Shadi Khademi, Ali Ghazavi, Ghasem Mosayebi,
Volume 9, Issue 4 (12-2006)
Abstract
Introduction: Oxidative stress may play a critical role in neurodegenerative disorders but the relation between oxidative stress and learning ability in normal rats is not investigated, so the aim of this study was to investigate the correlation between oxidative stress and two way active avoidance learning in Wistar rats. Materials and Methods: This is an experimental research. 14 Wistar rats were assigned for assessed learning ability in shuttle box. One day after shuttle box learning, cerebrospinal fluid (CSF) and blood samples were obtained. Concentration of Nitric Oxide and Ferric reduction/antioxidant power were assessed. Data was analyzed using Pearson correlation test. Results: The results of the present study demonstrate that there are positive correlation between shuttle box learning ability and Ferric reduction/antioxidant power (p<0.001, r =0.66 4) and Nitric Oxide concentration (p<0.001, r = 0.724) in serum, but not in CSF. Conclusion: The results of this study suggest that high concentration of antioxidant power and Nitric Oxide concentration in blood can improve shuttle box learning in rats
