Journal of Arak University of Medical Sciences

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The Effects of One Period of Swimming Training on IL-6 Concentration in Lung Tissues of Wistar Rats Following the Injection of Carcinogen NNK

Mohammadbagher Nikzad, Shadmehr Mirdar,
Volume 20, Issue 12 (3-2018)

Abstract

Abstract
Background: It is believed that sports exercises have minimal impacts on the pathological changes in the lung tissue exposed to chemical carcinogens in cigarette smoke. The aim of this study was to determine the effects of 12 weeks of swimming exercises on IL-6 concentration in the lung tissue of rats following the injection of carcinogen NNK.
Materials and Methods: This study is experimental in terms of the design. Forty-six Wistar rats were divided into five groups: A) Exercise (E), B) Exercise-NNK (EN), C) NNK (N), D) Control (C) and E) Vehicle (V). Exercise groups completed the swimming exercises for twelve weeks, five days per week (25-60min). Rats of vehicle and NNK treatment groups were respectively administered subcutaneous injections of distilled water and NNK (12.5mg/kg, once a week, 12weeks). Then, samples of the lung tissue were collected and IL-6 concentration was measured by ELISA technique. One-way analysis of variance and Tukey post hoc test were used for data analysis at the level of p ≤ 0.05.
Results: The results indicated a significant decrease of IL-6 concentration in exercise (p=0.009), exercise-NKK (p=0.006) groups and vehicle (p=0.006) with NKK groups; while there was no significant difference between exercise groups and the control groups. The swimming exercises can reduce IL-6 concentration significantly in lung tissue of rats following the injection of carcinogen NNK.
Conclusion: It seems that endurance exercises, along with other therapeutic methods, can play a role in reducing the effects of carcinogen NNK and negative effects of smoking by decreasing the inflammatory factor of IL-6.

Prediction of Juvenile Delinquency based on Individual Vulnerability and the Risk Opportunity in the Family, Peers, School and Neighborhood in High Schools in Tehran

Mojtaba Habibi, Nikzad Ghanbari, Moloud Sivandian, Hanieh Mahdizadeh Hanjani,
Volume 21, Issue 5 (10-2018)

Abstract

Background and Aim: Present study was conducted to investigate the prediction of juvenile delinquency based on individual vulnerability and the risk opportunity in the family, peers, school and neighborhood in high schools in Tehran
Materials and Methods: This is a coss-sectional study. The statistical population of this study included all the female and male students of 20 districts of Tehran who were studying in high school during the academic year 2013-2014. The sample size of the study was 1847 individuals (946 (51.2%) girls and 901 (48.8%) boys). The sampling was performed in a multi-stage cluster method due to the extent of the population, and the participants of this study completed the socio-mental protective and risk factors and behaviors scale. Data were analyzed using multiple regression analysis, stepwise method, and SPSS-24 statistical software.
Findings: Results of present study showed that among predictor variables, risk opportunity/availability (B=0.67, t=13.28, p<0.001), vulnerability/family (B=0.37, t=8.57, p<0.001), and vulnerability/school (B=1.14, t=6.7, p<0.001) have significant prediction effect on adjusted index of adolescents’ delinquent behavior, also adolescent boys do more delinquent behavior than girls (t (1823) =4.82, p<0. 01).
Conclusion: This study showed that the individual vulnerability and risk opportunity in the family, peers, school and neighborhood predict delinquent behavior in adolescents. So, it is necessary to take preventive measures and interventions for this age group, risk factors should be considered at individual, school and family levels.

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