Showing 2 results for Nakhai
Mahmood Reza Nakhai, Vali Razavieh , Reza Mahdavi, Mohammad Reza Palizvan, Siros Madadi Noie,
Volume 7, Issue 3 (Autumn 2004)
Abstract
Introduction: Impressive research demonstrates the importance of essential fatty acids for many physiological and bahavioral mechanisms in both human and animals. Essential fatty acids must be supplied via the diet. In this study we assessed the dietary effects of cis and trans fatty acids on seizures induced by pentylenetetrazol in rats.
Materials and Methods: In this study animals were divided into four groups. In the test groups cis, trans or cis and trans fatty acids were add to the standard foods of rats and in control group only standard food was dietary administrated. After one month kindling was established in rats with PTZ in subconvulsive dose (45 mg/kg). convulsing activities were monitored for 20 min.
Results: Results showed that there was no meaningful difference between rat groups receiving cis, trantary administration of cis and trans fatty acids had no effect on penylenetetrazol kindling in rats.s or cis and trans fatty acids in their standard food.
Conclusion: It was concluded that dietary administration of cis and trans fatty acids had no effect on pentylenetetrazol kindling in rats.
Raza Mahdavi, Seyed Vali Razavieh, Mahmood Reza Nakhai, Mahmood Reza Palizvan,
Volume 10, Issue 4 (12-2007)
Abstract
Introduction: Impressive research demonstrate the importance of essential fatty acids for many physiological and behavioral mechanisms in both humans and animals. Essential fatty acids must be supplied via the diet. In this study the dietary effect of cis and trans fatty acids on seizures induced by Pentylenetetrazol (PTZ) in second generation of rats is studied. Materials and Methods: In this experimental study animals were divided into four groups. In the three case groups cis, trans, or cis+trans fatty acids were added to the standard food of rats and in control group only standard food was dietary administrated. After one month, kindling was established in rats with PTZ in subconvulsive dose (45mg/kg i.p.). Convulsing activities were monitored for 20 minutes. Five stages of convulsing activities were observed. If after three consecutive sessions the animal was in the fifth stage, it was considered as a kindled animal. Data was analyzed using K-S, t, Tukey tests and analysis of variance. Results: Results showed that the convulsion stage in trans group was significantly more than the others. Also it was found that duration of the fifth stage in trans group was significantly more than control and cis groups. Conclusion: Results suggest that, administering sis and trans fatty acids have some effects on PTZ induced kindling in second generation of the rats who were kindled before. More severe seizure and longer duration of seizure was seen in trans group comparing to cis
