Showing 21 results for Mota
Jamal Fellahati, Hamidreza Nikbin, Jamshid Motamed,
Volume 3, Issue 4 (Winter 2000)
Abstract
Refractive error is a disturbance that a picture from one object is not on retina, in this reason picture is not clear. A clear picture is very important for development of visual nervous system to 10 years- old in children. This study was performed in 7 boys school in Arak. Today 753 boys student in the range of 6-11 years-old by the screening test was examined for visual acuity. Prevalence for refractive error was 9.5%. The most prevalence refractive error was pure myopia (56.9%). Family History in 65.3% was positive.
Sadrollah Motamed, Behzad Khorvash,
Volume 7, Issue 3 (Autumn 2004)
Abstract
Introduction: One of the most important problems in plastic surgery is reconstruction of extensive knee soft tissue defect. Many conditions cause this problem such as trauma, infection, burn and tumor resection.
Among different reconstruction techniques posterolateral thigh flaps are relatively new and it seems there is no published article of this technique in Iran. In this study we performed poaterolateral thigh flap to cover knee defect in 15 khordad hospital during 13800to 1382.
Materials and Methods: During 2 years 6 patients suffered from extensive knee soft tissue damage due to flame were under investigation. First they were treated with debridement and primary care and defects were covered with gastrocnemius flaps. Then defects were covered by posterolateral thigh flap, patients average hospitalization was 20 days and their average follow up time was 15 months. Data was gathered before and after surgery.
Results: Four cases had complete survival of flap. Two cases have a mild dissolation and necrosis which was treated by a limited debridement. All knee defects were completely covered. The donor site in one case had a hypertrophic scar which wad relieved during time statistical tess showed a meaningful relationship in all cases (p<0.05).
Conclusion: This flap was used successfully. we recommend this technique for similar conditions because of its easy usage.
Masoud Motamedi, Abbas Atari, Mansour Siavash, Fereshte Shakibaii, Mohamad Masoud Azhar,
Volume 10, Issue 4 (12-2007)
Abstract
Association between biological factors and disruptive behaviors in children and adolescents is important to investigate. Antisocial, aggressive and delinquent behaviors in adults often begin early in life. Basal cortisol is a valuable biological characteristic of children with disruptive behavior disorder (DBD). In this study the effect of family training on basal salivary cortisol in children with DBD was investigated. Materials and Methods: This is a clinical trial study. Basal salivary cortisol levels were studied in 19 children between 8-13 years old with DBD, before and 2 months after intervention (family training). The disruptive behavior of the child was assessed with child behavior checklist (CBCL). Cortisol levels and score of behavior were compared before and after intervention. Data was analyzed using descriptive statistics, paired t-test and pearson correlation. Results: Salivary cortisol before family training was 7.9±4.6 nmol/L and after that was 10.46±3.84 nmol/L which was significantly different (p<0.001). Behavior score before intervention was 72.05±10.10 and after that was 49.361±1.89 that was also significantly different (p<0.0001). Children with lower basal salivary cortisol had a better response to intervention. Conclusion: Parent training is an effective method for behavioral modification in DBD. Salivary cortisol can be considered as a predictive factor for severity of disruptive behavior, also a factor to assess the response to parent training in children with DBD.
Ebrahim Nabaee, Fereshteh Motamedi, Mohammad Ali Shariat Zade, Masoomeh Nabaee,
Volume 12, Issue 2 (9-2009)
Abstract
Background: REM sleep has a role in memory processing. The period of post-learning, that REM sleep is higher than normal level and deprivation of REM sleep impairs memory, is called paradoxical sleep windows (PSW). Methods and Materials: In this experimental study, male N.M.RI rats were trained in a two-way shuttle avoidance task (100 trials/one sessions) then memory retention was tested in next week. In electrophysiology section, different sleep-memory factors were recorded in basal level and 1-4 hours after training. In behavioral section, animals that reached 70% learning criterion (learner group) were deprived of PS in the two periods of 1-4 hours and 5-8 hours after learning by Maze water technique. Results: The amount of REM sleep in group which gained 70% learning after 1-4 hours training, and group without it. In v.s of basic level, significantly increase (p0.01). Other factors were showed no significant difference between two groups before of training. In behavioral section those animals were deprived in 1-4 hr post-learning show significant memory impairment (p0.05). Conclusion: Paradoxical increased REM sleep is effective in memory consolidation after 1-4 hours training. This period can be consider as paradoxical sleep window.
Fariba Faraji, Abbas S. Lotfi, Falamaki, Abdolamir Allameh, Afshin Mohsenifar, Batul Etemadikia, Ali Mota,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Aflatoxins, especially aflatoxin B1, have lethal effects on human and animal health. This study is intended to present a specific, sensitive, and relatively fast method for measurement, detection, and isolation of aflatoxin-albumin (Af-Alb) adducts in serum. Materials and Methods: In this experimental-trial, three groups of rats were selected and used as positive control (treated with aflatoxin B1), negative control (without treatment) and standard (treated with radioactive aflatoxin B1). After drawing blood samples from the rats, blood serum and then, serum albumin were isolated. Albumin was hydrolyzed by pronase and eventually, was injected into HPLC system. The sample was then identified and measured by fluorescence detector. Results: Electrophoresis on PAGE revealed albumin isolated from serum to be perfectly pure. In HPLC method, detection limit for the measurement of Af-Alb adduct was determined to be 60 pg/ml. The mean of aflatoxin positive control rats serum was 19.2 ng/mg albumin. In inter- and intra-group experiments, a remarkable level of reproducibility was seen for this method. Conclusion: The amount of Af-Alb adduct is proportionate to the amount of aflatoxin received. This project was conducted with rat serum sample, but since albumin is hydrolyzed and can be isolated from aflatoxin, this method is applicable to the measurement of Af-Alb adducts in human serum samples.
Ali Khavanin, Mohsen Soleimani, Mehdi Akbari, Ramazan Mirzaie, Masoud Motallebi, Hasan Asiliyan, Ardalan Soleimanian,
Volume 14, Issue 2 (5-2011)
Abstract
Background: Trauma noise is one of the major physical pollutants in modern societies. Sound conditioning, on the other hand, is known as one of the mechanisms for protecting the hearing system.
Materials and Methods: In this experimental study, 15 three month-old male white New Zealand rabbits were divided into three groups. The equipments used in this study included a sound generator, a loudspeaker, an exposure box, a sound level meter, and a distortion product otoacoustic emission (DPOAE) device. The rabbits were assigned to trauma noise exposure, conditioning noise exposure, and control groups. The conditioning and traumatic sound levels were respectively 80 and 105dB within the 500-3000 Hz frequency.
Results: Conditioning noise at the level of 80 in combination with trauma noise enhanced the rabbits hearing system tolerance up to 13-17 dB so that in all frequencies there were significant differences between the trauma noise exposure group and the sound conditioning and trauma noise conditioning group (P<0.05).
Conclusion: Sound conditioning can act as an effective factor in protecting the hearing system against trauma noise.
Bahman Salehi, Hassan Solhi, Amirreza Fotovat, Derakhshandeh Motamedi, Shirin Moradi, Somaieh Ebrahimi,
Volume 15, Issue 3 (August 2012)
Abstract
Background: Addiction is undoubtedly one of the biggest problems of human societies that every year governments spend enormous amounts of money on fighting it. Most addicts, besides their addiction, cause many psychological problems in their families therefore, the aim of this study was to compare the presence of these disorders between the families of addicts and non-addicts. Materials and Methods: This case-control study was done on a sample of 650 persons of opium addicts' and non-addicts' families using random sampling method. Data were collected through SCL-90-R questionnaire and were analyzed by Chi-square and t-test using SPSS software version 18. Results: There was a significant difference in psychiatric disorders in addicts' and non-addicts' families (p=0.005). Among the 9 psychiatric disorders under assessment, only anxiety, aggression, paranoia, and depression disorders in three types, including pathologic, borderline, and combined (pathologic-borderline), were significantly higher in addicts' families compared with non-addicts' families (p=0.005). Conclusion: Drug dependence disorder in one member of a family has a very important effect on the mental hygiene of the other family members and requires prevention and treatment in both.
Majid Motamedzade , Ali Dormohammadi, Hosein Amjad Sardrodi , Esmaeil Zarei , Reza Dormohammadi, Masoud Shafii Motlagh,
Volume 16, Issue 6 (9-2013)
Abstract
Background: Load lifting is the most stressful activity of the Manual Material Handling and can trigger of work-related musculoskeletal disorders of workers. Purposes of this study are determining the prevalence of musculoskeletal disorders, assessment lifting tasks by NIOSH lifting equation method, ergonomic design and assessment of its effectiveness.
Materials and Methods: This analytical and interventional study was performed on 30 workers in a Porcelain Health Manufacturing industry in Hamadan. Assessment of lifting tasks by NIOSH lifting equation and determining the prevalence of musculoskeletal disorders by Nordic questionnaire was conducted. Then, construction steps and determination of the effectiveness of ergonomic design was conducted.
Results: The results showed that the most frequent musculoskeletal disorders related to back. Results of the lifting index (LI) showed that the risk of lifting load in before intervention is high (greater than 3). This value after the conducting of ergonomic intervention (load-carrying cart) decreased to moderate level (between 1 to 3). The relationship of risk average amount before and after interventions were significant (p<0.001).
Conclusion: Load-carrying cart designed with shelves capable of moving vertically up and down has considerable role in safe making of lifting tasks and probability of reduce the prevalence of musculoskeletal disorders and lumbar injuries will bring in the near future.
Mehdi Hooshmandi, Narges Hosseinmardi, Mahyar Janahmadi, Fereshteh Motamedi, Azadeh Elahi Mahani, Fatemeh Sadat Aghamiri,
Volume 17, Issue 6 (9-2014)
Abstract
Background: Considering the increased activity of hypothalamic orexinergic neurons due to morphine administration, and its extensive projections to the hippocampus, it is probable that morphine effect on CA1 neuronal function is mediated by orexinergic system. So the effect of hippocampal orexin-1 receptors (OX1R) blockade on CA1 baseline synaptic response and short term synaptic plasticity was investigated.
Materials and Methods: In this experimental study, animals received morphine 10 mg/kg/12h/(SC) for 10 days. SB-334867-A, OX1R antagonist (0.5&mug/0.5 &mul), was microinjected intrahippcampally for OX1R inhibition before each morphine injection. Baseline synaptic response and short term synaptic plasticity were evaluated by field potential recording. fEPSP was recorded from CA1 following Schaffer collaterals stimulation. After Input/Output construction, short term synaptic plasticity was induced by paired pulse stimulations.
Results: Chronic use of morphine did not affect the baseline synaptic response (p>0.05). SB- 334867-A microinjection in CA1 did not have any effect on baseline synaptic response in morphine dependent rats. Morphine increased paired pulse index (PPI) at 80 ms inter pulse interval (IPI, p<0.05). SB-334867-A pretreatment did not affect this morphine induced PPI change.
Conclusion: The results suggest that orexin-1 receptors (OX1R) do not mediate the effect of morphine on baseline synaptic response and short term synaptic plasticity in CA1 area of the hippocampus.
Masoud Motalleby, Ashraf Mazaheri, Mohadeseh Mosayebi, Sayyed Mehdi Takhtfiroozeh,
Volume 18, Issue 5 (8-2015)
Abstract
Background: The air pollutants such as CO, SO2, NO2, O3, and particulate matters have harmful effects on public health. Determination of the actual concentration of the pollutants and description of air quantity and quality contents in comparison of standard conditions and timely informing people to regulate control programs is essential. Kashan is exposed to the winds contain-ing the suspended particulate matters due to the proximity of the desert. Moreover, the growth of population, factories and industries in the city are artifical resources of the air pollution. Hence, assessment and monitoring of air pollution standard condition in kashan is crucial.
Materials and Methods: In this cross-sectional and descriptive study, the concentration of CO, SO2, NO2, O3, and suspended particulate matters less than 10 microns (PM10) measured according to WHO standards in Panzdah-e-Khordad station of Kashan in 2011. The annual mean and maximum rates, the mean and maximum rate of summer and winter, and annual percentile 98%, determined for each pollutant and used in AirQ software. Then, the number of death and disease attributed to each pollutant was calculated.
Results: The results demonstrate that the cumulative number of deaths attributed to PM10, NO2, SO2, and O3 was 100, 22, 82, and 54, respectively.
Conclusion: In total, the suspended particulate matters have the most effects on death and disease resulted from the air pollution. Hence, managing the resources of particulate matters and SO2 pollutants has many effects on reducing the adverse health effects of air pollution in Kashan.
Seyyed Reza Attarzadeh Hosseini, Morteza Motahari Rad , Navideh Moien Neia ,
Volume 19, Issue 7 (10-2016)
Abstract
Background: The aim of this study was to investigate the effect of resistance training with different intensities on serum myostatin and follistatin levels in sedentary young women.
Materials and Methods: In this practical and semi experimental study, 24 sedentary young women with range of 20-30 years and BMI 22-25 kg/m2 were selected by convenience sampling. Then, the volunteers were randomly assigned into two groups, [resistance training group with low intensity (40-60% of one repetition maximum) and high intensity (70-90% of one repetition maximum)]. The training protocols included: 8 weeks, 3 times a week. Blood samples (5cc) were obtained at baseline and 48 hours after at the end of the study; Also Serum levels of myostatin and follistatin were measured by ELISA methods. Data were analyzed using analysis of variance of repeated measures test by SPSS at the significant level (p<0.05).
Results: There was a significant increase in the levels of follistatin and follistatin to myostatin ratio in high intensity group (p≤0.05). Also there was a significant decrease in the levels of myostatin in high intensity group (p≤0.05); however, there was no significant change in the levels of follistatin, myostatin and follistatin to myostatin ratio in low intensity group (p≥0.05). Also there was no significant change in these variables in high intensity group compared to low intensity group (p≥0.05).
Conclusion: It’s seems that the activation of important myogenic and myostatic factors in sedentary young women need to do high intensity resistance training.
Morteza Motahari Rad, Seyyed Reza Attarzadeh Hosseini,
Volume 20, Issue 2 (5-2017)
Abstract
Background: The aim of this study was to investigate the response of the most important angiogenic and angiostatic factors to a session activity before and after a period of L-Arginine supplementation in active men.
Materials and Methods: In this practical and semi experimental study, 22 active men were selected by convenience sampling method and they were randomly assigned into supplement (n=11) and placebo (n=11) groups. Baseline levels of VEGF and endostatin were measured, then subjects participated an exhaustive treadmill protocol in pre-test and post-test. Immediately and two hours after the protocol, 3 cc blood samples were prepared. The subjects used daily 0.1 g.kg-1 respectively taking l-arginine and placebo for 14 days. The results were analyzed at the significant level (p<0.05).
Results: Immediately after exercise, the levels of VEGF and VEGF to endostatin ratio were significantly decreased in both groups compared to baseline (p≤0.05), and two hours later this change were lower than the baseline value (p≤0.05). The levels of endostatin immediately after exercise were significantly increased in both groups compared to baseline (p≤0.05) and two hours later this change were lower than the baseline value (p≤0.05). Before and after L-Arginine supplementation, the levels, of VEGF and VEGF to endostatin ratio immediately after exercise were not significant(p≥0.05). while this change in the supplementation group were significantly increased two hours after exercise (p≤0.05). There was no significant change in the levels of endostatin between two groups immediately after exercise (p≥0.05); however, these changes were significantly decreased two hours after exercise (p≤0.05).
Conclusion: It seems that short-term L-arginine supplementation probably stimulate angiogenesis factors in response to exercise in active men.
Eslam Zabihi, Seyed Eghbal Motavallibashi, Khayam Bamdad, Faegheh Pilevaribadi, Hamid Sheikhkanloui Milan,
Volume 20, Issue 3 (6-2017)
Abstract
Abstract
Background: The multiple sclerosis is a chronic disease of the central nervous system. Since the level of sex hormone and multiple sclerosis (MS) disease affects one another, the aim of this study was to evaluate the impact of the hydroalcoholic extract of truffle on the hormone levels of estrogen and progesterone administered in experimental model of MS-induced rats.
Materials and Methods: In this experimental study, 42 Wistar female rats, weighing 180±10 grams selected into 6 groups each consisting of 7 rats. Normal control didn’t receive any treatment and experimental group was given Cuprizone toxin (as a MS model inducer) for 40 days. The experimental groups (2, 3, 4 and 5) in addition to Cuprizone received the normal saline, 110, 220 and 330 mg/kg/0.2ml (i.p.) of Hydroalcoholic extract of truffle for 12 days too. Blood samples were taken at the end of the twelfth day from all groups involved and levels of sex hormones were measured.
Results: Cuprizone decreases estrogen, progesterone levels and also causes weight loss, while injection of hydroalcoholic extract of truffle increased serum levels of estrogen (in experimental group 4) and progesterone (in experimental group 4 & 5) compared to MS-induced group.
Conclusion: Results of the study revealed that the hydroalcoholic extract of truffle (at dosages of 220 and 330 mg/kg) could increase estrogen and progesterone levels in rats experienced experimental multiple sclerosis.
Hamid Motamedi, Shahnaz Dehbashi, Hamed Tahmasebi, Mohammad Reza Arabestani,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Staphylococcus aureus(S.aureus) has many pathogens. Antibiotic resistance may increase the invasion of this bacterium. The aim of this study was to determine the role and effect of some antibiotic resistance in the spread of pathogenic strains of S.aureus in different clinical specimens.
Materials and Methods: 95 clinical isolates of S.aureus were collected from different clinical specimens. Antibiotic resistance pattern was determined by Disc diffusion method (Kirby-Bauer) for 6 different classes. Identification of adhesion agent genes in isolated isolates was performed using Multiplex-PCR and specific primers. For analysis of the results, GraphPad Prism version 6 and ꭕ2 statistical sampling was used. p≤0.05 was considered significant.
Findings: Of 95 isolates of S.aureus, 29 isolates (30.52%) were resistant to methicillin, 12 isolates (12.63%), resistant to clindamycin, 48 isolates (50.52%), resistant to gatyfloxacin, 88 (92.63%) isolates resistant to gentamicin, 57 (60%) isolates resistant to erythromycin and 79 isolates (83.15%) were resistant to tetracycline. fnbA genes were isolated in 14 isolates (14.73%), fnbB in 29 isolates (30.52%), fib in 21 isolates (22.10%), clfA in 17 isolates (17.89%) and clfB in 19 isolates (20%). There was a significant correlation between resistance to macular antibiotics, tetracycline, beta-lactam, lacosamide, aminoglycoside and pathogens.
Conclusion: The adhesion factors in S.aureus possibly cause some structural changes and cause resistance to various antibiotic classes.
Sara Vali Zadeh, Pezhman Motamedi, Hadi Karami, Hamid Rajabi,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Type 2 diabetes exerts an anti-angiogenesis effects on the cardiac tissue. The aim of present study was to investigate the effects of endurance training on gene expression of VEGF and VEGFR2 of cardiac tissue in type 2 diabetic male wistar rats.
Materials and Methods: 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (DET), Diabetic Control (DC) and Healthy Control (HC). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min and intensity of 75% VO2max for 20-30min in 1st week and reached to 27 m/min and intensity of 75% VO2max for 60 min/day in 10th weeks. The gene expression of VEGF and VEGFR2 were examined by Real-Time PCR AND Western Blotting.
Findings: The results of Real-Time PCR showed that the endurance training caused increase in VEGF mRNA (p<0.05) and VEGFR2 mRNA (p<0.05) compared to DC group. The results of Western Blotting also indicated that the endurance training induced increase in VEGF protein expression (p<0.05) compared to DC group and there was no significant change in expression of VEGFR2 protein (p>0.05).
Conclusion: Type 2 diabetes impairs the angiogenesis process in diabetic cardiac. It appears that endurance training has positive impact on angiogenesis and it can cause the improvement of diabetic cardiac.
Ali Asghar Ghorbanalipour, Pezhman Motamedi, Hamid Rajabi, Hadi Karami,
Volume 21, Issue 7 (2-2019)
Abstract
Background and Aim: The eNOS gene that is responsible for the production of nitric oxide and angiostatin is an inhibitor of angiogenesis. The aim of present study was to investigate the effect of endurance training on angiostatin and eNOS gene expression of cardiac tissue in type 2 diabetic male wistar rats.
Materials and Methods: In an experimental study, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (DET, n=12), Diabetic Control (DC, n=12) and Healthy Control (HC, n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 15 minutes in 1st week and reached to 27 m/min for 60 min/day in 9th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of angiostatin and eNOS were examined by Real-Time PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05.
Ethical Considerations: This study was approved in Research Ethics Committee of Arak university of medical sciences with the code IR.ARAKMU.REC.1394.329.
Findings: The gene expression of angiostatin and eNOS of DC group showed significant increase compared to HC group (p =0.000). The endurance training induced significant decrease in the gene expression of angiostatin and eNOS compared to DC group (p =0.000).
Conclusion: It appears that gene expression of angiostatin and eNOS of diabetic cardiac tissue are affected by positive effect of endurance training.
Zahra Salimi , Lotfollah Khajehpour , Farshad Moradpour , Ahmad Ali Moazedi , Ali Pourmotabbed ,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: Nilutamide is a pure non-steroidal antiandrogen that is used in the treatment of advanced-stage (metastatic) prostate cancer and acts as a potent and selective antagonist of the androgen receptors. Previous studies showed that there must be relationship between androgen receptors and cognitive aspects of the brain. Therefore, it seems that nilutamide affects spatial learning and memory through effect on androgen receptors. The aim of this study is to evaluate the effect of nilutamide on spatial localization in the Morris Water Maze and synaptic plasticity at the hippocampus CA1 area of male adolescent rats.
Materials and Methods: In this experimental study, male Wistar rats were randomly divided into 4 groups (n=9). Experimantal groups received vehicle (DMSO 10%) as control groups and different doses of Nilutamide (5, 10 and 15µg/2.5µl). Drug and vehicle were injected for 4 days before training.
Ethical Considerations: This study with research ethics code
EE/ 97, 24, 3061300/ scu.ac.ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz.
Findings: Analysis showed that escape latency and traveled distance for finding hidden platform in the group which received nilutamide (15µg) were significantly lower than of control group at first (p < 0.05) and second (p < 0.01) training days. The results of field potential recording showed that nilutamide had not any significant effect on fEPSP and PS.
Conclusion: The results of peresent study releaved that i.c.v microinjection of nilutamide improved spatial learninig in first and second days, wherease increase of treatment (4 days) not affected spatial learning.
Ailar Sabbaghi, Mohsen Zargar, Amir Ghaemi, Farahnaz Motamedi-Sedeh, Mohammad Reza Zolfaghari,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim We need the next-generation of whole-inactivated influenza vaccines to create stronger cross-protection against different influenza subtypes. This research aimed to apply the inactivation process of the influenza virus through gamma radiation as a candidate for the development of whole-inactivated vaccines.
Methods and Materials The influenza virus strain A/PR/8/34 (A/Puerto Rico/8/34 [H1N1]) was propagated in Madin-Darby Canine Kidney (MDCK) epithelial cells. After ultrafiltration, the virus infectivity titer was calculated by 50% Tissue Culture Infectious Dose (TCID 50%) method based on the Karber formula. Alternatively, the gamma cell-220 was applied for virus inactivation via gamma rays. The D10 value factor and optimum dose of virus inactivation were calculated based on the dose/survival curve and the initial viral titer. In addition, antigenic properties of irradiated viruses compared to un-irradiated viruses and complete inactivation of the irradiated samples with optimum dose were also evaluated by hemagglutination assay and safety test, respectively.
Ethical Considerations The Research Ethics Committee of Islamic Azad University, Tehran Medical Branch, Iran approved this study (Code: IR.IAU.TMU.REC.1397.309).
Results According to the concentrated virus titer (TCID50: 105.75/ml) and dose/survival curve, the D10 value factor and optimum dose of virus inactivation were calculated at 4.878 and 28.048 kGy, respectively. On the other hand, owing to the results obtained from the safety test and hemagglutination assay, the optimum dose of virus inactivation was determined to be 28 kGy by maintaining the antigenic properties.
Conclusion Gamma radiation appears to be a good candidate for vaccine development through maintaining the antigenic structures.
Eslam Zabihi, Seyed Eqbal Motavallibashi, Hamdollah Panahpour1, Hamid Sheikhkanloui Milan,
Volume 22, Issue 6 (February & March 2020)
Abstract
Background and Aim: Thyroid gland makes thyroxine (T4) and triiodothyronine (T3) hormones. These hormones are really effective in regulating and control of basal metabolism. The purpose of this study was to assess the effect of hydroalcoholic extract of Terfezia Boundary (TB) on the serum level of thyroid hormones.
Methods & Materials: In this experimental study, 30 male Wistar rats (weighing 200±10 g) were selected and divided into five groups of 6 including control, sham (received normal saline) and three experimental groups received TB with 75, 150 and 300 mg/kg doses via intraperitoneal injection for 14 days. Samples from all groups were collected at the end of the 14th day directly from the heart to evaluate thyroid hormone. The data were statistically analyzed in SPSS v. 12.
Ethical Considerations: This study was approved by the Research Ethics Committee of Ardabil University of Medical Sciences (code: IR.ARUMS.REC.1396.48).
Results: The results of this study showed that the T3 and T4 levels in the experimental groups 2 (150 mg/kg) and 3 (300 mg/kg) increased significantly compared to the control group (P<0.001 and P<0.01, respectively). The Thyroid Stimulating Hormone (TSH) level in the experimental groups 1 (75 mg/kg), 2 (150 mg/kg) and 3 (300 mg/kg) decreased significantly compared to the control group (P<0.05, P<0.001, P<0.001, respectively).
Conclusion: Hydroalcoholic extract of TB can increase the serum levels of thyroid hormones and reduce TSH level.
Abolfazl Kalantari, Hamid Rajabi, Pezhman Motamedi, Leila Poursaadat, Abbas Saremi,
Volume 25, Issue 6 (February & March 2023)
Abstract
Introduction: Increasing skeletal muscle contraction ability via increasing its neural stimulations, is one of the methods can be effective in sport performance improvement. The aim of the present study was to evaluate the effect of supramaximal isometric conditioning contractions on muscle neural excitation and performance indices during bench press exercise.
Methods: Current research is a semi experimental study performed on 8 athlete men. Age range of them was 19 – 23. Doing resistance trainings was a part of their exercise program at least 2 months before study onset. Bench press with Barbell was used in the protocol of these study. Electromyography was used in order to assay the neural excitation of main muscles which are activated during bench press. In addition, 1-RM test was done so as to assess the performance of these muscles. The protocol of this study was approved by the ethics committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1400.357). All subjects participated in this study voluntarily and they had no illness or injury at the start of the research.
Results: Neural excitation and performance of the muscles increased significantly during strength bench press, following conditioning contractions. This research was reviewed in Islamic Azad University - Arak Unit and approved with the ethics code IR.IAU.ARAK.REC.1401.096. Informed consent was obtained from the participants and they were assured that their information would be confidential
Conclusions: Doing supramaximal isometric conditioning contractions prior to doing strength bench press with barbell, increased neural excitation and performance indices of main muscles activated in this exercise.
