Showing 3 results for Mojarad
Mehrdad Roghani, Torandokht Baluch Nejad Mojarad ,
Volume 7, Issue 4 (Winter 2004)
Abstract
Introduction: Experimental animals like diabetes rats display an augmented nociceptive response to chemical, mechanical and thermal stimuli in long term. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of chard, this study was carried out to evaluate the possible analgesic effect of chard-mixed food intake in male streptozotocin-induced diabetic rats.
Materials and Methods: In this study rats were randomly divided into control, chard-treated control, salicylate-treated control, diabetic, and chard-treated diabetic groups. At the end of experiment, nociceptive response was evaluated in both acute and chronic phases of the standard formalin test based on a four level scale.
Results: Results showed that there was a significant increase in the number of pain scores in both acute and chronic phases in diabetic rats, and administration of chard for one month did not significantly reduce the pain scores in both phases of the test. Meanwhile, sodium salicylate as positive control, only reduced this score in the second phase.
Conclusion: It can be concluded that oral administration of chard for one month despite of its antidiabetic potential could not significantly reduce the nociceptive responses in diabetic rats.
Roghani, Khalili, Baluchnejadmojarad, Heydari,
Volume 14, Issue 1 (3-2011)
Abstract
Background: Chronic diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills. Noticing the existing evidence regarding the anti-diabetic potential of hesperetin, the effect of its chronic administration on learning and memory in diabetic rats was investigated. Materials and Methods: In this experimental study, 40 male Wistar rats were divided into control, hesperetin-treated control, diabetic, and hesperetin/glibenclamide-treated diabetic groups. For evaluation of learning and memory, initial (IL) and step-through latencies (STL) were determined at the end of the study using passive avoidance test, and the alternation behavior percentage was obtained using Y maze. Results: STL significantly decreased in the diabetic (p<0.01) and hesperetin-treated diabetic (p<0.05) groups in comparison to the control group however, the difference between these two groups was not significant. Alternation percentage in the diabetic group was significantly lower in comparison to the control group (p<0.05), but the hesperetin-treated diabetic group revealed a significant difference in comparison to the diabetic group (p<0.05). Conclusion: Although long-term treatment with hesperetin does not enhance the capability of retention and recall in diabetic animals on the passive avoidance test, it can improve the short-term spatial memory in diabetic animals.
Gholamreza Shookohi, Naser Hatami, Omid Mojarad, Ahmad Abolghazi,
Volume 25, Issue 3 (August & September 2022)
Abstract
Background and Aim Acanthamoeba is one of free-living amoebas, which are very abundant in nature. As a free-living amoeba, this parasite has a very high lethality, especially in people with underlying diseases, so researchers are always looking for a way to combat it. Drug plants are a good way to fight Acanthamoeba species. In this study, we aimed to investigate the lethal effect of the extract of Oliveria decumbens vent and Peganum harmala alcoholic extract on Acanthamoeba.
Methods & Materials In this study using the extract from an extract of Oliveria decumbens vent and Peganum harmala with concentrations of 1.25, 2.5, 5, 10, and 20 mg/ml to investigate the lethal effect of this extract. The plant was treated with Acanthamoeba amoebae after three times (24, 48, and 72) hours.
Ethical Considerations This study was approved by the Ethics Committee of the Jahrom University of Medical Sciences (Code: IR.JUMS.REC.1398.029).
Results The present research showed that using different concentrations at three times (24, 48, and 72) hours the effect of the extract on trophozoites and cysts of Acanthamoeba was shown. The highest lethality is related to the concentration of 20 mg/ml using a combination of both extracts at the time 72 hours and the lowest lethality is related to the concentration of 1.25 mg/ml of Oliveria decumbens vent at the time 24 hours.
Conclusion Observations indicate that the alcoholic extract of Oliveria decumbens vent and Peganum harmala had a perfect effect both separately and in a combination of both extracts. These two extracts had a synergistic effect on the lethal effect of Acanthamoeba amoeba.
