Showing 13 results for Mohseni
Akbar Mohseni Movahed, Ali Paknezhad,
Volume 1, Issue 2 (Spring 1997)
Abstract
Herediatry myeloperoxidase deficiency present in the homozygous form in about 1.9000 individuals.Heterozygotes showing a quantitative decrease in neutrpphil MPO concentration are common.Although there is some debate , MPO deficiency does appear , by itself , to predispose to increased infection. However MPO deficient subjects with an underlying chronic disease such as diabetes , have a significant increase in the incidence of candida infections. Acquired myeloperoxidase deficiency which must be distinguished from the hereditary form is associated with leukemias and thrombotic disease We found this case in 9 years old boy by using H1 Hematology system
Ali Fani, Iman Fani, Ramin Ghahremani, Abass Mohseni, Hamid Reza Soltani,
Volume 7, Issue 2 (Summer 2004)
Abstract
Introduction: Although more than two decades is passed from the discovery of H.pylori and its role in pathogenesis of upper GI disease, a uniform protocol for H.pylori treatment is not administrated yet. This research is conducted to evaluate knowledge, attitude and practice of physicians about H.pylori disease and treatment and its changes after reading a review article.
Materials and Methods: This is an interventional study. First we prepared a compact, review article for the purpose of teaching H.pylori pathophysiology, diagnosis and treatment. Then thirty questions was brought out to evaluate knowledge, attitude and practice of the physicians about H.pilory diagnosis and treatment. After the first evaluations we gave our article to the physicians to study. One month later we repeated the evaluation with the same questionnaire. Data was analyzed by SPSS software.
Results: 304 physicians participated in this study. The mean evaluated knowledge was 49.64-58.75 with 95% confidence interval; which after education increased to 57.94-74.14 (p<0.05). Mean level of attitude and practice was 53.01-71.67 with 95% confidence interval. After studying it increased to 61.54-80.83 (p<0.05).
Conclusion: The first step of the study showed that test and treat is the protocol of choice for many physicians. After primary evaluation and introducing the compact article there was a noticeable change.
Saeedeh Zafar Balanejad, Kazem Parivar, Javad Baharara, Homa Mohseni Koochesfahani,
Volume 12, Issue 1 (5-2009)
Abstract
Background: Angiogenesis is a complex process that occurs in many physiologic and pathologic conditions such as invasion and metastasis of tumors. Therefore, it is the target of many clinical treatments. Rapamycin is one of the immune system inhibitor drugs that recently has been used for controlling different types of cancer. In this study, the effect of Rapamycin on angiogenesis in chicks' chorioalantoic membrane was investigated. Methods and Materials: In this experimental study, we used 42 Ross fertilized eggs that were divided into 3 random groups: control, sham-exposed (treated by Dimethyle sulfoxide-DMSO- ) and treated with Rapamycin. In 2th day, a window was opened on eggs in the sterile condition. Later, in 8th day, a gelatin sponge appeared on chorioalantoic membrane and was soaked with 5 μl Rapamycin in treatment group and 5 μl DMSO in the sham-exposed group. In 12th day, CAMs were examined and photographed by Research Photostereomicroscope in all cases. The numbers and lengths of vessels around the sponges were measured and compared with each other by T-Test (p<0.05). Results: The mean of number (42 ±7.26 ) and length (57.25±5.05 cm ) for vessels in the control group and mean of number (42.93±8.37 ) and length (55.66±10.44 cm) in sham-exposed group was'nt any significant differences. There was a significant decrease in mean number (29.36±5.28) and length (44.55±10.22) of vessels in Rapamycin with control group. Conclusion: It seems Rapamycin has an inhibitory effect on angiogenesis in chicks' chorioalantoic membrane. It decreases the number and length of vessels around treated area
Fariba Faraji, Abbas S. Lotfi, Falamaki, Abdolamir Allameh, Afshin Mohsenifar, Batul Etemadikia, Ali Mota,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Aflatoxins, especially aflatoxin B1, have lethal effects on human and animal health. This study is intended to present a specific, sensitive, and relatively fast method for measurement, detection, and isolation of aflatoxin-albumin (Af-Alb) adducts in serum. Materials and Methods: In this experimental-trial, three groups of rats were selected and used as positive control (treated with aflatoxin B1), negative control (without treatment) and standard (treated with radioactive aflatoxin B1). After drawing blood samples from the rats, blood serum and then, serum albumin were isolated. Albumin was hydrolyzed by pronase and eventually, was injected into HPLC system. The sample was then identified and measured by fluorescence detector. Results: Electrophoresis on PAGE revealed albumin isolated from serum to be perfectly pure. In HPLC method, detection limit for the measurement of Af-Alb adduct was determined to be 60 pg/ml. The mean of aflatoxin positive control rats serum was 19.2 ng/mg albumin. In inter- and intra-group experiments, a remarkable level of reproducibility was seen for this method. Conclusion: The amount of Af-Alb adduct is proportionate to the amount of aflatoxin received. This project was conducted with rat serum sample, but since albumin is hydrolyzed and can be isolated from aflatoxin, this method is applicable to the measurement of Af-Alb adducts in human serum samples.
Somayeh Moukhah, Ziba Mazari, Azita Goshtasbi, Sakene Moaed Mohseni,
Volume 15, Issue 3 (August 2012)
Abstract
Background: Heavy menstrual bleeding is one of the leading causes of poor quality of life and iron deficiency anemia in women of reproductive age. This study was conducted to investigate the therapeutic effect of tranexamic acid (TA) on menorrhagia. Materials and Methods: In this before and after clinical trial, 46 women with menorrhagia were selected and, after a control cycle for evaluation of the volume and duration of primary bleeding, were subjected to tranexamic acid treatment (500mg every 6 hours from day 1 to 5 of bleeding) for 3 consecutive cycles. Data on the duration of bleeding, amount of bleeding (PBAC chart), quality of life (SF-36 and MQ questionnaires), and hemoglobin and ferritin values were checked and compared before and after treatment using SPSS software. Results: Tranexamic acid reduced mean PBAC score from 242.86 (160.47) in control cycle to 101.50 (72.67) after the third cycle (p<0.001). Hemoglobin increased from 11.85 (0.84) to 13.08 (0.97) g/dl and ferritin increased from 15.9 (20.39) to 22.13 (2.03) ng/dl (p<0.001). Duration of menstrual bleeding decreased from 7.6 (1.23) days to 6.86 (0.84) days (p=0.001). Tranexamic acid reduced mean MQ score from 70.26 (17.64) to 11.64 (6.49) (p<0.0001). Quality of life scores increased in all aspects (except for bodily pain scale) (p<0.001). Conclusion: TA due to its short course of prescription, fewer side effects, especially on the pattern of bleeding and menstrual cycle, and not having hormonal effects, seems to be an effective drug for menorrhagia in women of reproductive age.
Hamid Soori, Mojdeh Mortazavi, Armita Shahesmaeil, Hossien Mohseni, Mehdi Zangiabadi, Elaheh Ainy,
Volume 16, Issue 3 (6-2013)
Abstract
Background: Risky behaviours are defined as behaviours that cause bad and unpleasant outcomes. Risky behaviours result in the incidence of accident in the workplace. The aim of this study was to determine workers’ risky behaviours associated with safety and health in SAIPA Car Manufacturing Company, Iran.
Materials and Methods: In a cross-sectional study using randomized quota sampling, 302 workers exposed to the incidence of accidents were selected. Data were collected concurrently by trained safety experts using self-fulfilment researcher-made questionnaire and direct observation. Validity and reliability of the data collection tool was determined prior to the study.
Results: The findings revealed that low back pain, hand pain, leg pain, and respiratory diseases as the most common diseases with 86.4, 58.9, 40, and 33% prevalence rates, respectively. The maximum prevalence rates of unsafe and unhealthy behaviours were 66 and 57% , respectively. In general, unsafe behaviours were higher among shift workers, especially night shift workers (p<0.001). Unhealthy behaviours were higher among assembling line staff, welders, retouching staff, technicians, wet painters, and production line workers (p<0.001).
Conclusion: The relatively high prevalence of unsafe and unhealthy behaviours necessitates intervention for controlling and preventing work injuries and, as a result, reduction of musculoskeletal and respiratory diseases, especially with regards to more prevalent behaviours and related sectors and high risk subgroups.
Homa Mohseni Kouchesfahani, Khadije Sanamiri, Mahmoud Hashemitabar,
Volume 17, Issue 4 (7-2014)
Abstract
Background: Wharton's Jelly Mesenchymal Stem Cells (WJMSc) are potential renewable source of cells in replacement therapies of many diseases. Different biomaterials have been used as a scaffold to mimic the stem cell niche, which is important for promoting cellular interactions, cell proliferation and differentiation. Encapsulation involves entrapment of living cells within the semi-permeable membrane for the exchange of nutrients, oxygen and stimuli, whereas antibodies and host immune cells are kept out. In this study, a new approach for culturing and differentiating Wharton's Jelly Mesenchymal Stem Cells to definitive endoderm in a three dimensional environment using alginate capsules is presented.
Materials and Methods: In this experimental study, Wharton's Jelly Mesenchymal Stem Cells were capsulated and Trypan blue exclusion method was applied to determine cells viability. Then, encapsulated cells have been cultured in medium contain differentiating factors and to investigate the expression of definitive endoderm related genes, Real- time PCR was performed.
Results: The encapsulation procedure did not alter the morphology and viability of the encapsulated cells. Post-differentiation analysis confirmed the expression of FOXa2 and SOX17 as definitive endoderm specific markers.
Conclusion: Alginate has potential to be used as a three dimensional scaffold for culturing and differentiation of WJMSCs to definitive endoderm.
Maral Rostami Chayjan, Marjan Sabbaghian, Mehdi Alikhani, Fazel Sahraneshin Samani , Reza Salman Yazdi , Seyed Navid Almadani, Anahita Mohseni Mehbodi,
Volume 17, Issue 5 (8-2014)
Abstract
Background: Human &beta-defensin 126 (12kDa) is a small cationic glycoprotein that is highly rich of cysteine. DEFB126 gene is located on the subtelomeric end of 20p1.3 in human. High expression of this protein is reported in epididymis. This polypeptide coats the plasma membrane of sperm during epididymal transit. It is likely that &beta -defensin 126 might have role in unexplained male infertility since it involves in sperm maturation and capacitation. The current research designed to investigate if there is relation between &beta-defensin 126 gene mutation and unexplained male infertility.
Materials and Methods: In this case-control study we followed a two cytosine nucleotides deletion of &beta-defensin 126 gene in 35 Iranian men with unexplained infertility and 40 fertile men with normal spermogeram as control group. Standard PCR, SSCP(Single strand conformational polymorphism), and sequencing were used to detect genetic alteration of &beta-defensin 126. ELISA was performed for the assessment of the protein expression on sperm cells.
Results: Analysis of genetic data revealed 28.6% homozygote deletion in unexplained infertile men while this deletion was detected in 7.5% of controls. The deletion frequency was statistically higher in infertile patients than normal control group (p<0.05). The protein expression was less in men with del/del genotype compare to the other genotypes (p<0.005).
Conclusion: Our study shows that this common sequence variation of &beta-defensin 126 takes part in impairment of male reproductive function. Consequently, men with the del/del genotype are significantly less fertile than men who carry the wild type allele.
Homa Mohseni Kouchesfehani, Mina Mirza Mohamadi, Davood Sohrabi,
Volume 17, Issue 12 (3-2015)
Abstract
Background: Nanoparticles due to their small size can overcome blood-testis barrier and affect spermatogenesis process. The aim of this study is to investigate the influence of trioxide (MoO3) nanoparticles on histological changes of testis and spermatogenesis process in adult male Wistar rats.
Materials and Methods: In this experimental study 30 adult male Wistar rats were randomely divided into five groups (n=6), including control, 2 sham groups, and 2experimental groups. Control group had no treatment. Two experimental groups received doses 5 & 10 mg/kg/BW nano molybdenum trioxide (20nm) respectively, and two sham groups received the same doses of normal saline by intraperitoneal injection. After 28 days, rats testis was removed and fixed in Bouin’s fixative for histological examination. The 5&mum sections were stained with hematoxilin-eosin.
Results: In experimental group which received 5mg/kg/BW nanoparticle, there was some disorganization of spermatogenic cells in some seminiferous tubules. In experimental group which received 10mg/kg/BW nanoparticle, a significant decrease was also observed in the number of spermatogenic and sertoli cells in comparison with the control group.
Conclusion: According to the findings of this study exposure to the high doses of (MoO3) nanoparticles can disrupt male reproductive system in a dose- dependent manner. Hence, the application of (MoO3) NPs should be carried out cautiously.
Sahar Parsaee, Homa Mohseni Kochesfehani, Gholamreza Kaka, Homayon Sadraee, Mojtaba Kahali,
Volume 18, Issue 6 (9-2015)
Abstract
Background: Stress is a mental or emotional disturbance that occurs in response to external stimuli and can also appear during pregnancy. The aim of this study is to investigate the effect of maternal stress during pregnancy on the cerebellar structure changes and seizure threshold of their offspring .
Materials and Methods: In this experimental study, 20 pregnant female rats were divided into two groups: 1) Non stress group, and 2) Stress group which were under immobilization stress one hour for 14 days . The seizure threshold test in offspring was performed by injecting Pantilen tetrazol drug (PTZ)(n=8) . To investigate the cerebellum development, the offspring were divided into three groups . Control group: mothers did not any stress and offspring did not receive PTZ (n=4). Sham group: mothers did not stress but the offspring had received PTZ(n=4). Experimental group: mothers did stress and offispring did receive PTZ(n=4). After the section of cerebellum, the thickness of cerebellum layers and the number of cells in each layer were evaluated.
Results: The mean of seizure threshold in the offspring whose mothers were under the stress of pregnancy significantly increased compared to children whose mothers no received stress (p<0.001). In the other side, mean number of purkinje cells in the experimental group significantly decreased compared with the other groups (p<0.001). No significant differences were found in the mean of granular and molecular layers thickness of cerebellum in the experimental group when compared with the other groups(p<0.05). However, mean cellular density in the granular layer of cerebellum in the experimental group significantly decreased compared to other groups (p<0.001).
Conclusion: Stress during pregnancy increased the seizure threshold in offspring and caused some developmental and structural disorders in the cerebellar rat offspring.
Begher Seyedalipour, Ali Hasani, Mohammad Ali Ebrahimzadeh, Mojtaba Mohseni,
Volume 18, Issue 11 (2-2016)
Abstract
Background: Lamiaceae family has about 200 genuses and 4000 species. The majority of species of the family have essence that was used for nutritional, cosmetic and pharmaceutical industry. The aim of this study was to investigate the chemical composition of essential oil from aerial parts of Bollota platyloma and antibacterial activity of it.
Materials and Methods: In this experimental study, study Ballota platyloma, belonging to lamiaceae family and entomic of iran, was collected from Versk region in Mazandaran provinc. Essential oil from aerial parts was obtained by hydro distillation method by using Clevenger apparatus. GC/MS analysis of essential oil was carried out to identify major volatile constituents. Extraction was prepared by maceration method. Antibacterial activity of methanolic extracts against Pseudomonas aeruginosa, Bacillus subtilis, Stapylococcus aureus, Escherichia coli was investigated by disc diffusion method and minimal inhibitory concentration(MIC) method.
Results: Results showed that GC/MS analysis of the essential oil confirms the presence of 24 constituents in Ballota platyloma. The main constituents were Hexadecanoic Acid (40.03%), Germacrene D (26.6%) and Beta Caryophylene (4.76%). The results indicated that methanolic extract of Ballota platyloma possessed antibacterial activity. Among the aforementioned bacteria, the highest antibacterial activity was seen against S. aureus and the lowest activity against P. aeruginosa.
Conclusion: The findings of the present study showed that the major component of oil essential was germacrene-D and methanolic extract from the aerial parts of Ballota platyloma Rech. f. possess anti-bacterial effects. Thus, in order to find the underlying mechanism of this activity, further research should be carried out.
Zhila Mohseni, Iraj Javadi, Saeed Shanaghi,
Volume 21, Issue 4 (8-2018)
Abstract
Background and Aim: The history of using bleomycin in a hospital indicates a series of vast reactions in biological systems caused by direct and indirect effects. The biological responses of the biological system make this process more complicated. Increasing the prevalence and the incidence of cancerous diseases that are treated with bleomycin is of paramount importance. The aim of this study was to evaluate the effect of niacin on reducing the complications of bleomycin consumption in human model.
Materials and Methods: This experimental study was done as case-control and double-blind clinical trial. Of the cancer patients referred to Khansari hospital in Arak that underwent the bleomycin monotherapy, 20 subjects were randomly selected and divided into two groups. Each person in the first group (control) received 2 placebos per day (every 12 hours) and the second group (treatment) were given two pills of niacin (each pill: 100 mg) daily, and the results were recorded and analyzed.
Findings: A comparison between treatment and control groups showed a reduction in nausea and vomiting in the treatment group compared to the control group. The sense of taste disorder complication was reduced in the treatment group compared with the control group and this difference was statistically significant (p <0.05).
Conclusion: The results suggest that niacin can decrease the side effects of cancer treatment from different directions, including side effects, nausea, vomiting, loss of sense of taste, but its impact on respiratory problems probably because of the damage caused by bleomycin was not significant.
Fatholah Mohaghegh , Mehran Mohseni, Nasrin Robatmili, Mohamad Reza Bayatiani , Fatemeh Seif, Nayyer Sadat Mostafavi,
Volume 21, Issue 6 (12-2018)
Abstract
Background and Aim: Radiation therapy is the destruction of cancer cells that in all patients with breast cancer reduces tumor recurrence, relieves pain in local tumors and metastases. There are different treatment methods around the world such as electron, photon alone or a combination of both types of fields.
Materials and Methods: In this study, photon therapy (PT) and mixed photon-electron therapy (MPET) were used to treat malignancies of the supraclavicular lymph nodes. 30 patients with right-sided breast cancer with local lymph node metastasis were recruited. The ISOgray software was utilized to collect data about treatment planning methods with PT and MPET.
Findings: The maximum and mean delivered doses of radiation to the supraclavicular region were 52.08±1.64, 42.59±0.51 Gy and 54.24±1.64, 43.67±0.43 Gy in the PT and MPET methods, respectively. The mean irradiated volumes of supraclavicular fossa that received 90% of the radiation dose were 59.74±1.94% and 70.26±0.94% in the PT and MPET methods, respectively (p=0.004). The maximum doses delivered to the spine were 14.66±1.9 Gy and 10.22±0.92 Gy and the thyroid were 42.62±3.1 Gy and 37.67±5.02 Gy in the PT and MPET methods, respectively.
Conclusion: The maximum doses delivered to the spine and thyroid significantly diminished by the novel method. Additionally, supraclavicular region received higher maximum and mean doses in the new treatment modality compared to the conventional methods. The new method improved dose coverage for the tumor.
