Amir Hoshang Mohammad Alizadeh , Ali Reza Maghoolzadeh,
Volume 7, Issue 2 (Summer 2004)
Abstract
Introduction: Hp is the most common human infection which can result in gastritis, peptic ulcer and gastric adenocarcinoma and lymphoma. Several combinations of drugs have been tested in HP eradication. Thyme is a herbal drug that has antiseptic and GI anti spasmodic characteristics. In this study we tested Thyme combination regimen in comparison with routine regimes.
Materials and Methods: This is a randomized clinical trial study. 90 patients with GI symptoms, confirmed peptic ulcer and HP infections, were divided into three groups, group A (Omeperazole, Bismuth, Metronidazole and Tetracycline), group B: Omeperazole, Bismuth, Metronidazole, Tetracycline and Thyme and group C: Bismuth, Omeperazole, Tetracycline and Thyme. Duration of treatment was 2 weeks . after treatment they were given Ranitidine for 2 weeks and 2 weeks without any treatment and then they were evaluated for HP and peptic ulcer.
Results: Distribution of sex, age, and smoking was equal in three groups, 81 (90%) of cases had upper epigastric pain. Clinical recovery rate was 96.6% in group B and C which was more than group A (p=0.43). After treatment endoscopy showed 70% complete relief in group C which was significantly more than two other groups (p=0.04). Complete response rate (negative RUT+ negative HP histology) was 46.7% in group C (p=0.03).
Conclusion: In general, group C regimen that substituted Thyme with Metronidazol was more effective in HP eradication. With regard to high effectiveness, low complication and low cost of Thyme, we suggest that adding this drug to routine quadriple HP eradication regimens could be useful.
Mojgan Mirghafourvand, Aziz Homayouni Rad, Sakineh Mohammad Alizadeh Charandabi, Kolsoum Shokri,
Volume 18, Issue 8 (11-2015)
Abstract
Background: Constipation is a functional gastrointestinal disorder and the use of probiotics is considered as a new solution in prevention and treatment of constipation. The aim of this study is to review the clinical evidence about probiotics effects in the prevention and treatment of constipation.
Materials and Methods: To review the accessible evidence about efficacy of probiotics in the prevention and treatment of constipation, the search of key words such as constipation, probiotic and yoghurt are conducted in databases Pubmed, Medlinplus and Cochran from 1980-2013 and of 49 articles about constipation, 16 yandomized controlled clinical trial articles and 3 pre-test and post-test randomized trials that investigated the effects of probiotics on constipation were included in this study.
Results: Probiotics produced lactic acid and fatty acids with short chains that decrease the colon pH and stimulate muscular contractions and intestinal peristalsis. Some of probiotics can increase the mucous discharge and change linked bile salts to free bile salts entering much water to colon and leads to soft defecation.
Conclusion: Considering studies, daily use of probiotics such as lactobacillus acidophilus and bifidobacteria lactic 105-1011 CFU/gr for at least 1-2 weeks can help to decrease constipation.
