Majid Moghadaszadeh, Ebrahim Fattahi, Mohamad Hosein Somi, Manochehr Khosh Baten, Toraj Rosta,
Volume 15, Issue 2 (June-July 2012)
Abstract
Background: H. pylori infection is common worldwide involving 50% of the general population. The aim of this study was to compare the effect of two sequential regimen therapies on the eradication of H. pylori. Materials and Methods: In this clinical trial, 150 patients were allocated to two groups of 75 each: group A and group B. The eradication of H. pylori in groups A and B was based on azithromycin and ofloxacin sequential regimens, respectively, and the results were compared between the groups. The data were analyzed by t-test, Chi-square test, and Fisher’s exact test using SPSS software version 16. Results: Mean of the patients’ age was 39.3± 1.2 within the age range of 18 to 85 years. There were not significant differences between the two groups considering the type of peptic ulcer. In group A, Urea Breath Test (UBT) was negative in 67 (89.3%) patients while in group B, it was only positive in 8 (10.7%) patients. In group B, there were 64 (85.3%) negative and 11 (14.7%) positive UBT test results. There were no significant differences in H. pylori eradication rates between the two groups (P=0.31). Conclusion: Noticing the absence of a significant difference between the two groups in terms of H. pylori eradication, it can be concluded that ofloxacin-based drug regimens have no superiority over azithromycine-based regimens and each regimen can be prescribed considering drug complication rates in different patients.
Gholamreza Najafi, Rahim Hobe Naghi, Aref Hoshyari, Masoud Moghadaszadeh, Behzad Ghorbanzadeh,
Volume 15, Issue 10 (March 2013)
Abstract
Background: Atrazine is an herbicide used widely by farmers in controlling weeds. The aim of this investigation was to evaluate the effect of atrazine, as an herbicide, on sperm quality, sperm DNA damage, invitrofertilization (IVF), and embryonic development in mature male rats. Materials and Methods: In this experimental study, 42 mature male Wistar rats weighing 170±5g were divided into three groups, including one control and two treatment groups. The rats in the control group were administered corn oil (0.2 ml/day) and the rats in the test groups were orally gavaged with atrazine 150mg/kg (high dose) and 75mg/kg (low dose) body weight daily for a total of 45 days. Epidydimis tail was cut and placed in 1 ml of human tubular fluid (HTF) medium for 30 minutes in an atmosphere of 5% CO2 in air at 370C. The sperms were analyzed for sperm count, sperm viability, motility, DNA damage, immature sperm, and in vitro fertilization. Data were analyzed by One-Way ANOVA. Results: In this study, atrazine provoked a significant decrease (P<0.05) in sperm number, sperm viability, and sperm motility. The data suggest that the atrazine had a negative impact on sperm maturation and DNA integrity in a time-dependent manner, which consequently caused a significantly remarkable reduction in IVF ability (P<0.05). Conclusion: Atrazine is capable of inducing DNA damage and chromatin abnormalities of spermatozoa which can contribute to a low fertilization rate.
