Journal of Arak University of Medical Sciences

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Showing 3 results for Modaresi

Study on the Effect of Sodium Bicarbonate in Serum Iron TIBC on Rats

Heydar Farahani, Homa Modaresi,
Volume 3, Issue 2 (Summer 2000)

Abstract

As might be expected iron deficiency leads to anemia, and it is found around the world. Due to its need during the pregnancy, WHO paid attention to "childbearing health" in 1998. Absorbance of iron depends on gastric secretion and HCL for efficient absorption. In present research three groups of rats, which contain 15ones, with the same diet, sex, age and condition were selected. Diet of groups A and B contained 5g/kg and 10g/kg sodium bicarbonate respectively and the diet of group C as a control group was free of sodium bicarbonate. After 3 months, we used ether as the anesthesia and removed blood directly from the heart, serum were separated and Iron, TIBC measured. Also PH of gastric secretions was estimated, the mean of PH in group C(3), group a (3.8) and group B(3.8) was observed. Finally we found out that the levels of Iron and TIBC in group C were 72.5mg/dl and 35mg/dl, in group A 69.1mg/dl and 480.2mg/dl and in group B 52.8 and 309.9mg/dl respectively. On the basis of our results, we suggest that the using of sodium bicarbonate along diet effects on the absorption of Iron- which is due to the changes of gastric acidity comparing to control group.

An Investigation on Intestinal Parasitic Infections and the Effective Demographic Factors in Children (1-3 Years) in Shahrak-E-Valiasr Arak During 1999

Mohammad Hassan Davami , Mohmood Reza Khazaii, Zahra Eslamirad, Maryam Mostofi , Masoumeh Modaresi,
Volume 5, Issue 2 (Summer 2002)

Abstract

Introduction: Alimentary parasitic infections are still one of the main problem in developing countries, and their relation with environmental factors are important. Since children are more vulnerable to these infections, in basic researchers this group is more targeted.
Materials and Methods: This descriptive-analytical cross-sectional study was carried out on 1-13 years children who were living in Shahrak-e-Valiasr Arak. Simple random sampling was used for selecting 385 children. Three days collected feces samples from each person were examined using formaline-ether concentration technique. Data were analyzed by Chi square method.
Results: The results showed a prevalence of 42.3% of intestinal parasitic infections in the children. From these, 17.4% were pathogen parasits. The highest prevalence was reported for Giardia lambia (16.6%). Girls were more infected than boys. The level of infection was significantly increased by age. The prevalence of the infection was more in orphans or in children who had uneducated parents.
Conclusion: Since date indicated of a high prevalence of intestinal parasitic infections in the children. It is suggested to use washed and clean vagetables and fruits and also emphasize on personal and environmental hygiene.

The Comparison Between Hydroethanolic Extraction of Pistacia Atlantica and Suzin Effects on Growth Inhibition of K562 Cell Line in Vitro Condition

Fatemeh Keikhaei, Nooshin Naghsh, Mehrdad Modaresi,
Volume 17, Issue 6 (9-2014)

Abstract

Background: Leukemiais a malignant and progressive disease of the Hematopoietic tissues of the body. The pistacia atlantica tree base, the geographic in large areas of the Mediterranean and the Middle East is growing. K562Cell class is considered as laboratory model of chronic phase of human CML. We compared the growth inhibitory effects SUZIN as a chemical compared with pistacia atlantica as a combined Zn plant antioxidant capacity in reducing cancer has been studied.

Materials and Methods: Pistachio nut was collected from around Kerman, then they were dried in room temperature and extraction was performed for 48 hours by maceration method. K562 cell class was incubated in medium RPMI-1640 fortified with 10%(v/v) FBS and 50% Streptomycin-Penicillin. Cytotoxic effect of hydro-ethanolic extract of pistacia atlantica against cancer cells K562 was evaluated in three interval by MTT method. Light absorbance by Eliza device was measured in wave length 540 nm. Statistical analysis was performed using SPSS15 software and ANOVA test.

Results: Pistacia atlantica in 24h and in concentration 100&mug/ml andSuzin in48h and in 12.5 &mug/ml,72 h and in 50 &mug/ml induced growth inhibition half of the cells were K562. Results obtained from changes in cell morphology influenced by hydro-ethanolic extract of pistacia atlantica and SUZIN suggest abnormal transformation of cells that probably represents apoptosis and necrosis.

Conclusion: Time and concentration against cytotoxic effect of Pistacia atlantica have the combined effect. Whileiron supplementation, alone time is due. Special concentration of pistacia atlantica having high antioxidant capacity with the Suzincan be considered as a potential target for inhibiting K562 cells in treatment of blood cancer.

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