Journal of Arak University of Medical Sciences

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Variability of Antioxidant Defense Enzymes in Primary Angle Closure Glaucoma Patients in Comparison with Healthy Subjects

Gholam Reza Shahsavari, Asghar Mohammad Pour Konani, Arezou Miraftabi,
Volume 18, Issue 2 (5-2015)

Abstract

Background: Oxidative stress and antioxidant status may be associated with glaucomatous damage. The purpose of this study was to compare the serum antioxidant status between primary angle closure glaucoma patients and healthy subjects.

Materials and Methods: In this case-control study 66 primary angle closure glaucoma patients and 80 controls were enrolled. Peripheral blood sample obtained from patients. Superoxide dismutase(SOD) was assayed by inhibition the rate of adrenochrome formation. Catalase (CAT) was evaluated by decrease of H2O2 absorbance. Glutathione peroxidase (GPx) and Glutathione reductase (GR) were determined following NADP oxidation or reduction. Glutathione S-transferase (GST) was measured by increase in the absorbance of CDNB and glutathione conjugation.

Results: Antioxidant defense enzymes were significantly decreased in glaucoma patients over those of control groups. CAT (p<0.006), SOD (p<0.020) and GPX (p<0.004). A relative insignificant decrease of GR and GST activities was observed in glaucoma patients compared with healthy subjects.

Conclusion: The present study supports the hypothesis that oxidative stress is an important factor in the pathogenesis of glaucoma. Although primary angle closure glaucoma has an anathomical basis but decrease in antioxidant defense enzymes activities may have a role in pathogenesis of this type of glaucoma.

Five Years Outcome of Ahmed Glaucoma Valve Surgery in Refectory Glaucoma

Naveed Nilforushan, Arezoo Miraftabi, Maryam Yadgari, Sayyed Amirpooya Alemzadeh, Mahsa Hashemian,
Volume 21, Issue 3 (6-2018)

Abstract

Background and Aim: The aim of this study was to evaluate the success rate and complications of Ahmed Glaucoma Valve (AGV) insertion during a follow up of at least 5 years.
Materials and Methods: In this retrospective case series study, patients with 5 years of follow up after AGV insertion were enrolled. Success was defined as intraocular pressure (IOP) < 21 mm Hg (criterion A) and IOP < 16 mm Hg (criterion B), with at least 20% reduction in IOP, either with no medication (complete success) or with no more than preoperative medication (qualified success). Cumulative success was defined as sum of qualified and complete success.
Findings: This study included 40 eyes of 40 patients with mean age of 40.63± 22.91years, (range 1 to 88). Cumulative survival success rates were 90%, 73% at 1 and 5 years after surgery according to criterion A and 42%, 25% based on criterion B with the median survival time of 60 months and 22.36 months, respectively. Complications were observed in 4 eyes of 4 patients (10%) and included wound dehiscence, choroidal detachment, encapsulated bleb and lid retraction. There were not any early complications such as hypotonia or hyphema.
Conclusion: The present study was one of the largest series that reported the long-term outcome of AGV implantation in Asian patients with refractory glaucoma, and showed the wide difference of success rate between criterion A and B.

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