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Showing 4 results for Mansouri
The Investigation of the Prevalence of Coronary Artery Diseases In Arak and the Role of Education in their Deletion or Modification Instraction
Valiollah Khadir, Aryan Mansouri,
Volume 4, Issue 2 (Summer 2001)
Abstract
Coronary  artery  diseases  are  the  most  important  cause  of  mortality  in  many  countries  and  there  are  many  risk  factors  where  by  reducing  its  prevalence  or  side  effects  by  deletion  or  control. This  study  has  done  in  Arak  in  two  stages  on  1050  patients  who  were  over  20 years.  They  included  750  women  and  300  men  who  were  selected  randomly. In  first  stage  factors  in  total  investigated  population  were  as  follow: Hypertension  20.7%, hyperglycemia 5.8%, obesity 30.2%  and  positive  family  history  21.9%. 385  patients  were  investigated  with  necessary  educational  programs  after  six  months  and  they  had  at  least  one  risk  factor  which  can  be  modified  or  deleted  without  need  to  drug  use. It  was  cleared  that  in  men  and  women  respectively  cholesterol  13,15.2% (P<0.0001), triglyceridemia 36, 18.5% (p<0.0001), body  mass  index 4, 4.3% (p<0.0001), systolic  blood  pressure 10,5.6% (P<0.0001)  and  diastolic  blood  pressure  were  11, 7.5%  (p<0.0001) decreased.  Blood  sugar  shoed  significant  reduction  in  women  40.1%  (P=0.001)  and  cigarret  smooking  didn’t  show  significant  reduction  in  two  sexes.

Comparing the Amount of EMG Activity of the Selected Involved Muscles in Ankle Strategy in Female Athletes While Standing on One Leg on Shuttle Balance and Wobble Board
Reyhaneh Mansouri, Reza Rajabi, Hooman Minoonejad,
Volume 18, Issue 2 (5-2015)
Abstract

Background: It seems that using shuttle balance which has recently been produced in Iran would be beneficial in exercise prescription for preventing sports injuries and recovery. The purpose of this study is comparing the amount of the electromyography activity of involved muscles in ankle strategy while standing on one leg on shuttle balance versus wobble board.

Materials and Methods: This study is a functional and cause-compare study. 15 female students 20-22 years of age having the enterance standards were selected meaningfully. The amount of EMG activity of selected muscles (Tibialis Anterior, Gastrocnemius, Rectus Femoris and Hamstring) was measured while standing on one leg on two devices. The difference in means of muscles activity in both of devices was estimated using multivariate analysis of variance.

Results: The results showed a significant difference between the amount of EMG activity of involved muscles (p=0.001). Also, the results of the intragroup effects showed that the electromyography activity of Tibialis Anterior, Rectus Femoris and Hamstring while standing on shuttle balance was significantly more than the activity while standing on wobble board (p<0.05). While the amount of activity on shuttle balance was higher as compared to wobble board, but there was no significant difference in Gastrocnemius EMG activity between two devices (p>0.05).

Conclusion: It seems that standing on shuttle balance can make higher electromyography activity in the muscles that are involved on ankle and thigh joints, i.e. Tibialis Anterior, Rectus Femoris and Hamstring. So it is recommended that shuttle balance can be used in balance training program.


Bioinformatic Screening of Human Papillomavirus (HPV) E1 and E2 Inhibitor(S) from Phyllanthus Emblica and Ficus Religiosa
Komeil Amini, Kamran Mansouri,
Volume 21, Issue 5 (10-2018)
Abstract
Background and Aim: Human papillomavirus (HPV) infection is a prevalent, life-threatening disease and cause of cancer among women. Therefore, in recent years, developing novel anti-HPV agents is highly regarded. The study was planned to bioinformatic screening for E1 and E2 potential inhibitors of HPV serotypes including 16,18,31,33 and 45 types from medicinal plants.
Materials and Methods: This is a descriptive-analytic study. In the first step, three-dimension structure of phytochemicals were retrieved from PubChem database and then the cell cytotoxicity and mutagenesis potential of them were evaluated. In the next step, the amino acid sequences of two key proteins of mentioned types of HPV including E1 and E2 were obtained from Uniprot database. Furthermore, the conserved and variable regions of the protein sequences were predicted using multiple sequence alignment method. Finally, the three-dimension structure of mentioned proteins was determined by homology modeling method and potential interactions of the phytochemicals with the proteins were investigated using molecular docking method through Autodock 4.2.6 software.
Findings: The results demonstrated that ursolic acid has no cytotoxicity and mutagenesis potential with appropriate physicochemical properties. Results also showed that mentioned compound had strong interaction with both E1 and E2 of all studied serotypes. Furthermore, the evaluation of ursolic acid and E1 and E2 interactions showed that amino acid is involved in conserved regions of mentioned serotypes.
Conclusion: Based on the obtained results of present study ursolic acid could be good candidate for more in vitro and in vivo studies of its anti HPV activity.

The Sensitivity and Specificity of American College Of Emergency Medicine Guideline in Predicting the Need for Computed Tomography Scan in Patients with Mild Head Trauma
Morteza Gharibi, Simin Najafgholian, Fatemeh Rafiee, Ali Nazemi, Esmaeil Mansourizadeh,
Volume 22, Issue 5 (11-2019)
Abstract
Background and Aim American College Of Emergency Medicine (ACEM) guideline has a recommendation for early diagnosis of head injuries following mild trauma. In this study we examined the prediction power, sensitivity, and specificity of this clinical guideline in the need for computed tomography (CT) scan 
Methods & Materials This cross-sectional study was performed for 6 months on patients over 18 years old referred to the emergency department of Vali-e-Asr Hospital in Arak who met ACEM criteria for head CT scan for suspected mild trauma. Demographic characteristics, clinical symptoms, trauma mechanism, physical injuries caused by head trauma, and history of drug abuse were recorded. The consciousness level (Glasgow Coma Scale) was checked every two hours. Patients underwent treatment if there was a pathology in CT images, and those with no clear pathology were discharged after 6 hours and, followed up by phone for two weeks, and in case of any abnormality in the level of consciousness, they were re-examined by CT scanning.
Ethical Considerations This study has an ethical approval obtained from Arak University of Medical sciences (code: IR.ARAKMU.REC.1396.227).
Results 500 patients, 335 male (67%) and 165 females (33%) with the mean age of 46.39± 2.01 years were studied; the sensitivity the ACEM guideline for predicting the need for CT scan in patients with mild head trauma were 100% with a specificity of 3.46% (for the second recommendation, the sensitivity was 100% with a specificity of 6.7%) which indicated that the test was highly sensitive to diagnosing the patients, but its specificity was low.
Conclusion The ACEM guideline had high sensitivity to predicting the need for CT in patients with mild head trauma, but had very low specificity which makes it an unacceptable criterion for rejecting or performing CT scan in these patients.

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