Journal of Arak University of Medical Sciences

Study of Perforation of Tympanic Memberane in Referred Patients to E.N.Clinic of Amir-Kabir Hospital of Arak

Saeid Tafreshi, Mehran Mansoori Sarevestani,
Volume 1, Issue 4 (Autumn 1997)

Abstract

Tympanic membrane perforation is a world wide common problem particularly in under developed & developing countries. In the current study 352 patients were studied in a period of 6 months period. The age of the patients were between 2.5 to 86 years old. It wasn’t possible to find any significant difference between men and women. The most common form of perforation was central, and the least form was total. The most common cause of perforation was infection with traumatic manipulations and compression injuries coming after. The average amount of hearing loss was found to be 31.9 db which shows presence of some degrees of ossicular and middle ear malfunction.

A Comparison of Diabetes Mellitus Incidence Between Atypical and Typical Antipsychotic Drugs in Janbazan With Mental Disorder

Saeed Mansoori , Abas Attari, Masoud Amini , Reza Bagherian,
Volume 7, Issue 3 (Autumn 2004)

Abstract

Introduction: Atypical antipsychotic drugs in comparison with typical antipsychotics produce fewer extra pyramidal symptoms at clinically effective doses. However there has also been a growing number of reports of new onset diabetes mellitus in patients receiving these drugs. The aim of this study was the comparison of diabetes mellitus incidence in mentally janbazan (Iran-Iraq war veterans) undertaken typical with atypical antipsychotics.
Materials and Methods: In this study the incidence of new onset Dm was assessed in 200 subjects referred to Amiralmomenin clinic, Isfahan, Iran. Every patient was included in this study if he was receiving atypical or typical antipsychotic drugs or combination of both types, at least for one year. Sampling was convenient. Fasting blood sugar, triglyceride and cholesterol before taking the drugs was documented in their records. New onset DM was defined based on 126 mg/dl or more for FBS which was confirmed with GTT. For comparison of FBS mean pre and post interventions, NIDDM incidence, the relation of background variables with NIDDM and the relation of NIDDM incidence with dosages and duration of drug therapy, paired t-test, chi-square, logistic regression and ANOVA were used.
Results: Subjects were divided into three groups based on the type of drugs used 135 patients using typical antipsychotics (chlorpromazine, perphenazine, haloperidol, …), 39 patients using atypical antipsychotics (clozaoine & riaperidon) and 26 patients receiving combination of drugs. It was found that DM developed following treatment in three groups were 12.8%, 6.7% and 3.8% respectively. There was no significant differences between three groups regarding the incidence of new onset DM.
Conclusion: Findings showed that patients treated with antipsychotic drugs had a moderately increased risk of DM especially with atypical antipsychotics. It is suggested to evaluate every patients before treatment for risk factors of DM.

The effect of three-week intensive interval training on Lipocalin-2 and Interleukin1-β in healthy and adult rat Hippocampus

Bahman Hasanvand, Rahman Soori, Sadegh Abbasian, Mahsa Rastegar Moghaddam Mansoori,
Volume 20, Issue 1 (4-2017)

Abstract

Abstract

Background: In response to the exercise, variety of inflammatory and anti-inflammatory changes in cytokines were occurred into the tissue spaces and also to the systemic circulation. The purpose of the current study was to determine the effect of three-week intensive interval training on Lipocalin-2 and Interleukin1-β in healthy and adult rat hippocampus.

Materials and Methods: Twenty Wistar rats were divided into training and control groups. Training group performed 15 (bouts) × 4 (min) exercise training for 60 min with 85 to 90% of VO_2max used for four sessions/week (for 3 weeks). Then, blood (for ELISA analyzing) and tissue sampling was performed from rat’s hippocampus and they were evaluated by using a Real-Time PCR method. Also, independent and paired t tests were used to define within and between group differences.

Results: Findings showed that gene translations of Lipocalin-2 and Interleukin1-β were significantly decreased in rat’s hippocampus (p=0.0001 and p=0.0001, respectively). Also, similar decreases were shown in serum levels of Lipocalin-2 and Interleukin1-β in rats (p=0.017 and p=0.003, respectively).

Conclusion: It seems that significant decrease of Lipocalin-2 subsequent of short-time intensive interval training is due to decreasing and significant changes in Interleukin1-β. Also, current training protocol on treadmill can significantly decrease levels of Lipocalin-2 and Interleukin1-β in rat serum and hippocampus.

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