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Manizheh Kahbazi , Alireza Farahani ,
Volume 1, Issue 5 (Winter 1997)
Abstract

Nowadays the securing of children health and then the maintenance of community health is training programs about health, but before every health programs. Knowing the believes and tendency of people is necessary. The knowledge and attitude of mother regarding to supplementary food before and after the training were measured based on KAP study .( knowledge, Attitude , Practice ). The result of this study is as follows:
1-3.58% of studied mothers had good knowledge, 41.2% moderate knowledge, 55.38% weak knowledge before training and raised to 80.51% good knowledge, 19.48% moderate knowledge following training.
2- 95.56% of studied mothers had positive attitude and 4.46% negative attitude before training  that raised to 100% positive attitude to supplementary food following training.
3- Statistically, there is no meaningful relationship between the knowledge of mothers regarding to supplementary food and number of child, job, but there is a relationship with the level of education.(0.025)

Mozhgan Hashemieh , Ali Amani,
Volume 1, Issue 5 (Winter 1997)
Abstract

Exclusive breast feeding for the first six months of the life and then breast feeding with supplemental nutrition of the two year of age are the best way of feeding. Although almost all mothers are able to have successful breast feeding, many infants are still being fed by fomula or receiving supplemental nutrition from the first month of life. In this study, information about 400 infants between 4-6 months of life fed by non-exclusive breast feeding method chosen with simple randomization has been gathered. The most common cause of non-exclusive breast feeding was infantile restlessness (36.2%). The other causes include: incorrect mothers belief about milk insufficiency, family advices, fewer weight gaining of infants (7.7%), business of mother (6.5%), maternal and infantial diseases (2.2%) and advice of some physicians (2%).Although 75% of the mothers has been educated during pregnancy of perinatal period, but they did not feed exclusively their infants with breast milk.

Manizheh Kahbazi,
Volume 4, Issue 2 (Summer 2001)
Abstract

Hypoglycemia  is  one  of  the  most  common  preventable  and  curable  metabolic  disorders, especially  seen  in  low  birth  weight  infants. About  80%  of  hypoglycemic  conditions  are  asymptomatic  or  the  symptoms  will  present  between  the  third  to  fifth  days  after  birth  that  infants  are  discharged  from  the  hospital. However  even  in  asymptomatic  cases, hypoglycemia  has  exposed  the  infant  to  sever  defects  of  nervous  system  development  which  these  defects  depended  on  duration  and  severity of  hypoglycemia  will  be  remained  as  reduction  of  head  circumference  and  psychomotor  disorders  for  child  especially  in  3  to  5  years  old. We  studied  284  LBW  infants  that  about  5.2%  of  them  were  hypoglycemic  in  the  first  24  hours  after  birth. (Blood  glucose  was  less  than  30, g/dl). About  80%  of  cases  were  asymptomatic. 20%  of  showed  were  symptomatic  such  as  hypotonia, generalixed  convulsion  with  apena  and  total  cyanosis.  These  infants  were  of  twin  pregnancy  or  Cesarian  section. We  also  studied  infants  based  on  gestational  age. (Preterm &  IUGR) The  prevalence  of  hypoglycemia  in  preterm  infants  was  2.3%  and  6.6%  in  IUGR  infants. There was  no  significant  relation  between  the  sex  and  incidence  of  hypoglycemia . The most  common  prevalence  of  hypoglycemia  were  seen  in  infants  with  body  weight  between  1500 -2000  grams.
 

Mehrangiz Zamani, Fatemeh Soltan Beigi,
Volume 4, Issue 3 (Autumn 2001)
Abstract

Introduction: Primary  dysmenorrhea  with   prevalence  of  90%  is  the  one  of  the  most  gynecologic  problems  and  it  is  one  of  the  important  ethiology  of  decrease  of  quality  of  live  in  women.  The  treatment  is  varity  cocp, NSAIDS  (common  treatment)  The  use  of  acupuncture. Tens, Laparascopic  surgery, vitamin  B1  acid -3 omega, transdermal  N.G. (nitroglycerin)  in  the  studies  were  evaluated  but  the  number  of  cases  and  the  period  of  follow  up  is  limited.  In the  study  in  India  with  Gokhale  and  et.al  in  1996, the  curative  Rate  of  treatment  with  Vitamin  B1  was  proved.  In  this  study  we  evaluated  the  treatment   effect  of  Vitamin  B1, and  follow  up  the  patients  3  months  later  and  6  months  after  the  onset  of  treatment.
Material  and  Method: In  this  study  2  years  between  1999-2001  a  Randomized  double  blind  placebo  controlled  study, one  group (118-n)  received  Vitamin  B1  (100 mg)  and  other  group  (124=n)  received  placebo  daily  in  the  onset  of  three  month  treatment  and  end  of  treatment  and  6  months  later  of  onset  of  treatment  the  patient  is  calculated  with  visual  analgesic  scale  and  cox-menstrual  scale.
Results: The  prevalence  of  primary  dysmenorrhea  in  the  population  of  this  study  was  51/9%  mean  age  of  menarche  13/3  year.  The  rate  of  NSAID  using  is  63/1%. 85/5%  of  patients  had  irregular  menses.  The  prevalence  of  premenstrual  sign. And  the  signs  correlated  with  dysmenorrhea  were  evaluated  between  two  groups  of  treatment  evaluated  3  months  after  treatment  period  in  the  placebo  control  care  rate  was  21%  and  in  Vitamin B1  was  86/4%  (chi=103.59  p value=0.000).
Conclusion:  The  results  in  this  study  were  similar  with  the  results  of  Gokhale  in  India.  This  treatment  did  not  have  any  side  effect  and  this  treatment  tolerated  easily.

Laleh Soleimanizadeh, Teymor Agamolaei ,
Volume 5, Issue 2 (Summer 2002)
Abstract

Introduction: The  purpose  of  this  research  is  to  examine  depression  rate  in  nursing, midwifery  and  health  students  and  its  relation  with  individual  perception  about  being  religious  in  Hormozgan  University  of  Medical  Sciences  and  Health  Services.
Materials  and  Methods: In  this  study  299  students (105  male  and  194  female)  were  examined  with  non-random  and  easy  sampling  method. They  examine  with  Beck  Depression  Test  and  Alport  Religious  Guidance.
Results: On  the  basis  of  Beck  Depression  Test  55.5%  were  without  depression, 32.1%  mild  depression, 11%  moderate  depression  and  1.3%  sever  and  very  sever  depression. Also  with  use  of  two  dimension  Alport  Religious  Guidance, 8.7%  of  subjects  had  external  and  91.3%  internal  religion.  On  the  basis  of  other  classification  of  Alport  Religious  Guidance  70.9%  of  subjects  had  high, 21.4%  moderate  and  7.7%  low  religion.  By  the  means  of  x2  Test  it  shows  the  rate  of  depression  between  girls  and  boys  have  not  significant  difference (p>0.05). In  order  to  access  relationship  between  the  rate  of  depression  and  religious  viewpoint, Pearson  Correlation  Test  was  used  that  results  show  that  it  is  reverse  correlation  between  them. So  that  with  increased  religious  viewpoint  the  rate  of  depression  was  decreased (r=-0.6, p<0.05)
Conclusion: In  low  religion  subjects, the  rate  of  depression  was  more  than  religion  subjects.
Manijheh Kahbazi , Susan Marefati ,
Volume 5, Issue 2 (Summer 2002)
Abstract

Introduction: Asthma  is  one  of  the  most  chronic  long  disease  of  childhood  that  caused repeated  admitting  in  hospital  &  school  day  lost.  Asthma  identifies  with  recurrent  attack  of  cough, dyspnea  &  wheezing. The  goals of  treatment  are  relief  of  Acute symptoms, prevention  or  diminish  the  frequency  of  recurrent  symptoms  maintain  normal  pulmonary  functions  &  maintain  normal  activity  level.
Materials  and  Methods: In  our  study, all  patients  with  final  diagnosis  of  asthma  that  hospitalized  in  Amir-Kabir  hospital  from  79.1.1  to  80.1.30  evaluated.
Results: first  line  drugs  that  used  Aminophylline (62%), antibiotics 56%, corcosteriod 42%, inhaled  salbutamol 14% and  oral  salbutamol  0.6%. others  that  used  in  the  period  of  treatment  according  to  prevalence  are  antibiotics  85% , aminophylline  74%, corticosteroid  5%, oral  salbutamol  40%, adrenaline  31%, inhaled  salbutamol  24%  & theophylline_G 14%.  Most  of  clinicians  use  aminophylline  instead  of  beta  agonist, Only  14%. patients  receive  inhaled  salbutamol  in  the  first  line.
Conclusion: There  findings  reflect  inappropriate  therapy  of  asthma. It  seems that  little  knowledge  of  clinicians  about  new  medical methods, absence  of  new  drugs  and  little  knowledge  of  patients  &  their family  of  patients  and  their  norriment  about  use  of  inhaled  drug, are  basic  problems.  That’s  logical, that  education  of  clinicians  &  patient  their  parents, explanation  the  mandatory  of  preparation  of  new  drugs  &  proper  device  to  manages  can  resolve  their problems.
Malek Soleimani-Mehrunjani, Mohammad Ali Shariat-Zadeh,
Volume 6, Issue 1 (Spring 2003)
Abstract

Introduction: Compensatory renal growth (CRG) is growth of the remaining functional nephrons and interstitium alter some nephrous have been surgically removed or damaged due to disease. This growth includes the increase of kidney weight caused by hepertrophy and hyperplasia. Although uremic patients are often treated with growth hormone (GH), it is thought that GH may actually increase the degree of renal hypertrophy and the progress of CRG to the scarring and therefore accelerate renal failure. The aim was ultrastructural study of the effects of recombinant human growth hormone (rhGH) on the renal tubulointerstitial changes following 5/6 nephrectomy (SNX).
Materials and Methods: For this 48 rats from mule Lewis and Dwarf Lewis rats strains were used. Each strain was divided to control, control+rhGH, SNX and SNX+rhGH groups. Dwarf rats strain have only 10% of circulating GH compared to the normal strain one month later the rats were injected with exogenous growth hormone (thGH) or saline two times per day for 30 consecutive days.
Results: The results showed tubular basement membranes was partially thickened in control thGH group and it was too thickened and multi-layered in the SNX groups. Tubular basement membrane was too thickened in the SNX-TGH group in compared to SNX only. Many of Convoluted tubules lost their apical architecture and mitochondria often appeared damaged and cytoplasm contained increased numbers of lysosomes. After SNX areas of focal fibrosis were common. These areas were become infiltrated with modified fibroblasts and myofibroblasts were present. The interstitium become filled with extracellular fibres and amorphous material.
Conclusion: It is evident that many of these changes were made more sever by treatment with thGH in both strains following SNX. So it seems GH caused more synthesis of extracellular matrix proteins and ultrastructural changes of the renal tubulointerstitial.
Manijheh Kahbazi ,
Volume 6, Issue 2 (Summer 2003)
Abstract

Introduction: Children play an important role in the future of every country. In under developed countries like Iran, because of cultural and economic poverty, most children have malnutrition which will be result in physical and psychological growth disorders. In as much as zinc is one of the most important and essential elements in metabolism of different substances and human growth, this study was conducted to determine the effect of zinc supplementation on percentile weight of children with growth disorders.
Materials and Methods: In order to investigate the effect of zinc sulfate syrup on increasing the weight and percentile weight of children, a double-blind clinical trial was conducted in 70 children aging 9 to 36 months. The subjects lacked any associated disease-by laboratory testing. Thirty-five children consume zinc sulfate syrup 0.6% for three months (case group) and other consume daily placebo for the same time and dose (control group). The increase of weight percentile of children were measured in three times with the interval of one month.
Results: Our findings showed that during three months, the average amount of increasing in weight percentile was 4.5% and 3.7%, respectively. T test showed that the comparison of increasing in weight percentile between two groups was not significant
Conclusion: This investigation revealed that zinc supplementation had not any remarkable effects on increasing of weight and weight percentile of children with growth disorders.
Hadi Hasankhani , Eisa Mohammadi, Farhad Moazami , Manijheh Mokhtari, Mohammad Mahdi Naghizadeh,
Volume 6, Issue 4 (Winter 2003)
Abstract

Introduction: Postoperative hypothermia is physiologically stressful by elevating blood pressure, heart rate and plasma catecholamine concentration. This study conducted to evaluate the effects of intravenous fluids temperature on perioperative hemodynamic situation.
Materials and Methods: This was a randomized clinical trial study Perioperative pulse rate, blood pressure, intraoperative esophageal and skin temperature were measured in 60 volunteer patients undergoing orthopedic surgeries subjects randomly divided into two groups according to intraoperative IV fluids management. In 30 patients (hypothermia group) all IV fluids infused were at room temperature. In the other 30 patients (normothermia group) all IV fluids were warmed using and dry IV fluid warmer.
Results: The core and skin temperature of hypothermia and normothermia group decreased significantly from induction of anesthesia toward end of surgery but its reduction was more in hypothermia group (P<0.005). Postoperative mean arterial blood pressure increased significantly more in hypothermia group versus normothermia group (P<0.005). Shivering was observed in 21 of 30 hypothermia and 11 of 30 normothermia group (p<0.005) and recovery time was significantly lower in normothermia group (36±5 vs. 26±3 min, P<0.005).
Conclusion: Infusion of warm fluids helps to reduce the variation of postoperative mean arterial blood pressure, core and skin temperature, occurrence of shivering and recovery time.

Hamid Abtahi, Ali Hatef Salmanian, Sima Rafati, Ghorban Behzadian Nejad,
Volume 7, Issue 1 (Spring 2004)
Abstract

Introduction: Brucellosis is one of the most important zoonotic diseases that causes miscarriage and infertility in animals and causes human fever. The use of the common SS9 strain of Brucella abortus has several side effects for livestock. Brucella P39 protein is one of the plasma peripheral space proteins that is considered as one of the important immunogenic indicators. With the production of the new protein combination of P39, more studies can be done on the ability of this protein to stimulate immune responses against Brucella. Therefore, in this research, the production and purification of this protein in Escherichia coli bacteria has been done as a new compound.
method: In this experimental study, using the polymerase chain reaction, the P39 gene was propagated by the bacterium Brucella abortus. After purifying the P39 gene, it was cloned into plasmid carriers pSK+ and pGEX4T1. Therefore, pSK+-P39 and pGEX4T1-P39 structures were prepared. To produce the recombinant protein P39, the plasmid structure pGEX4T1-P39 first entered the Escherichia coli bacterium BL21. The protein was then produced by IPTG by induction of pGEX4T1-P39 plasmid. The resulting protein was purified using the orderly purification protein glutathione S-transferase. The amount of purified protein was measured using the Brad Ford method.
Results: The nucleotide sequence of the gene propagated by the cloned PCR in the plasmid carrier  pSK+ was exactly the same as the P39 gene of Brucella abortus. Production of P39 protein was performed by induction of pGEX4T1-P39 plasmid. The purified protein content was 200 micrograms per milliliter.
Conclusion: The production of the new protein P39 compound Brucella Abortus, which is unstable in the cytoplasm of the Escherichia coli bacterium, is possible using carriers with additive proteins such as pGEX4T1 in the host of Escherichia coli strain BL21.
Mohammad Reza Etemadifar, Hamid Germani, Mohammad Hossein Dehghani,
Volume 7, Issue 1 (Spring 2004)
Abstract

Introduction: Radius end fracture is one of the most common fractures of the upper limb, the treatment of which is controversial, and improper treatment can have significant side effects. In this study, we intend to examine the results of treatment with an external fixative method.
method: It was easy to study without control and sampling. The study was performed on 30 fractures (26 patients) for one year, based on radiographs of the fracture site of type 4 universal 5. Surgery with standard techniques was performed under general or regional anesthesia, and patients were followed up for up to one year after surgery and examined for shortness of breath, joint surface angle, range of motion, and pain.
Results: Twenty-four men and two women with a mean age of 5.28 years were examined. In all patients, clinical and radiographic effusion occurred. There were two cases of mild infection at the site of the pin, which were treated with medication. In one case, there was a slight sensation in the sensory branch of the radial nerve, which disappeared after a while, and in no case was there a tendon lesion. The mean deviation to the palm was 6.6.5.5 and the ulnar deviation was 4.5 to 12.5.
There were 4 cases of pain during strenuous activity, 2 cases of mild movement restriction and one case of severe movement restriction.
Conclusion: Compared to other studies, the results of this study are much better in many cases and it is recommended to use this treatment in the treatment of unstable fractures of the lower end of the radius and especially if it develops into the radiocarpal joint.
Fatemeh Dareh, Roya Kelishadi, Manijheh Kahbazi, Cathayon Rabii, Saeid Heidari, Abdolmehdi Baghaei,
Volume 7, Issue 1 (Spring 2004)
Abstract

Introduction: Among the risk factors for coronary artery disease, less attention has been paid to physical activity, especially in children and adolescents. Various studies have shown that their level of physical activity is lower than the standard for maintaining lower health. In this study, the pattern of physical activity of children and adolescents in the central regions of Iran is examined.
Method: In this descriptive study, which is part of the first phase of the Isfahan Healthy Heart Project and was conducted in 2002, awareness of the attitude and performance of 4,000 urban and rural children and adolescents in preschool to high school in Isfahan (Isfahan, Najafabad) and Markazi (Arak city) and the parents of these students and 500 teachers and school officials have been examined about physical activity and the duration of watching TV through a questionnaire. Sampling was selected in the form of a random cluster and in proportion to the urban and rural population living in the two provinces. Data were analyzed with SPSS software and p<0.05 were considered significant.
Results: About 40 percent of middle and high school students in the two provinces practiced regular sports at school less than two hours a week. Regular morning exercise and school sports were more common in girls than boys (p<0.00001), but regular extracurricular exercise and sports team membership were more common in boys (P<0.001). More than 77 percent of parents were unaware of the importance of childhood exercise in their children's health. The average TV viewing time for children of different ages was 4 hours a day.
Conclusion: The level of physical activity of middle and high school students in the central regions of Iran is less than the desired level and the duration of watching TV is more than the recommended values.
Ali Fani, Iman Fani, Ramin Ghahremani, Abass Mohseni, Hamid Reza Soltani,
Volume 7, Issue 2 (Summer 2004)
Abstract

Introduction: Although more  than  two  decades  is  passed  from  the  discovery  of  H.pylori  and  its  role  in  pathogenesis  of  upper  GI  disease, a  uniform  protocol  for  H.pylori  treatment  is  not  administrated  yet.  This  research  is  conducted  to  evaluate  knowledge,  attitude  and  practice  of  physicians  about  H.pylori  disease  and  treatment  and  its  changes  after  reading  a  review  article.
Materials  and  Methods: This  is  an  interventional  study. First we  prepared  a  compact, review  article  for  the  purpose  of  teaching  H.pylori  pathophysiology, diagnosis  and  treatment.  Then  thirty  questions  was  brought  out  to  evaluate  knowledge, attitude  and  practice  of  the  physicians  about  H.pilory   diagnosis  and  treatment. After  the  first  evaluations  we  gave  our  article  to  the  physicians  to  study.  One  month  later  we  repeated  the  evaluation  with  the  same  questionnaire.  Data  was  analyzed  by  SPSS  software.
Results:  304  physicians  participated  in  this  study.  The  mean  evaluated  knowledge  was  49.64-58.75  with  95%  confidence  interval;  which  after  education  increased  to 57.94-74.14 (p<0.05). Mean  level  of  attitude  and  practice  was  53.01-71.67  with  95%  confidence  interval. After  studying  it  increased  to  61.54-80.83 (p<0.05).
Conclusion: The  first  step  of  the  study  showed  that  test  and  treat  is  the  protocol  of  choice  for  many  physicians.  After primary  evaluation  and  introducing  the  compact  article  there  was  a  noticeable  change.   
Manijheh Kahbazi , Ali Chehreie,
Volume 7, Issue 3 (Autumn 2004)
Abstract

Introduction: Good  nutrition  is  important  for  growth  and  development  of  children. Regarding  the  fact  that  most  of  brain  growth  is  done  in  first  years  of  life, the  importance  of  a  good  nutrition  at  this  time  can  not  be  denied. In  our  country  there  is  a  high  incidence  of  growth  failure.  Todat  the  complementary  nutrition  teaching  is  being  performed  by  primary  care  provider  and  physicians  are  less  active  in  this  important  field.  In  this  study  we  investigated  the  effect  of  complementary  nutrition  teaching  by  physicians  on weight  of  children  with  growth  failure.
Materials  and  Methods: This  study  is  a  before  and  after  clinical  trial.  In  this  study  100 children  between  6-24  months  old  with  growth  failure  and  no  disease as  the  result  for failure  were  investigated.  Their  mothers  were  educated  about  complementary  nutrition  by  physicians.  Then  children,s  weight  was  assessed  every  month  for  three  months.  Results  were  comparisoned  with  the  data  from  three  months  before  education.
Results: In this  study  45%  of  children  were  male.  The  mean  of  age  was  11.38  months. There  was  a  meaningful  difference  between  the  difference  of  mean  weight  in  the  end  of  the  without  teaching  period  and  its  firast  (-0.49)  and  the  difference  between  the  mean  weight  in  the  end  of  the  teaching  period  and  its  first (1276 gr) (p<0.001). The  difference  of  z  score  at  the  first  of  teaching  period (1.25)  in  comparison  with  the  without  teaching  period (0.04)  was  meaningfully  increased.
Conclusion: In  general  mothers  complementary  nutrition  teaching  by  physician  had  an  effective  role  in  resolving  childrens  growth  failure  and  improving  their  weight  gain.  We recommend  that  when  physicians  are  confronted  with  children  with  growth  failure  it  is  better  to  perform  complementary  nutrition  education  as  a  priority  instead  of  performing  paraclinic  studies.  
 
Mohammad Ali Shariatzadeh, Malek Soleimani, Abdolrahman Dezfulian, Mitra Noori, Esmaeel Roodi,
Volume 7, Issue 4 (Winter 2004)
Abstract

Introduction: Diabetes  during  its  progress can  result  in  nephropathy.  Some  of  its  symptoms  are  increasing  kidney  size  and  weight  and  its  components.  Regarding  useful  components  of  onion  and  its  antioxidant, decreasing  stress  oxidative  and b decreasing  blood  glucose  effects. This  investigation  is designed  to  study  the  effect  of  onion  water-alcohol  extract  in  preventing  nephropathy  and  its  effect  on  kidney  structure  based  on  stereology  method.
Materials  and  Methods: Four  groups  of  matured  vistar  rats (n=8)  were  selected randomly (control  group, control + extract  group, diabetic  only  group, diabetic + extract  group). Diabetes  was  induced  by  injecting  interperitoneal  sreptozotocin  (60mg/kg). The  control+ extract group  and  diabetic + extract  group  were  treated  by  onion-water  extract (50 mg/rat)every day  for  four  weeks. Then  all  groups  were  anesthetized  and  their  left  kidney  was  removed  and  fixed  in  Bouin  fixative. After  histologic  passage  and H & E  dying, using  stereologic  techniques, qualitative  measurement  was  performed  by  Cavalier  method  for  cortex, medulla, glomerulus  and  kidney  size.  Data analysis  was  done  by  SPSS  software  using one  way  anova, tukey  and  paired  test. p<0.05  was  considered  significant.
Results: The  primary  and  secondary  weight  of  rats  in  only  diabetic  group  and  diabetic  + extract  group  was  not  different, but  in  control  group  and  control  + extract  group  was  significantly  different (p<0.05). Medulla, cortex  and  whole  kidney  size  in  only  diabetic  group  in  comparison  with  diabetic+ extract  group  had  no  difference, but  total  glomerular  size  in  diabetic  only  group  and  diabetic + extract  group  was  significantly  different (p<0.001).
Conclusion: Experimental  induction  of  diabetes  by  STZ  in  a  short  period  showed  that  onion  extract  can  prevent  glomerular  hypertrophy  and  increasing  kidney  weight  in  diabetic  rats, but  had  no  effect  on  overall  kidney  size. So  the  study  of  onion  extract  effects  on  kidney  structure  during  a  long  period  is  recommended.      
 
 
 
Dr Hamid Abtahi, Dr Ali Hatef Salmanian, Dr Sima Rafati,
Volume 9, Issue 1 (3-2006)
Abstract

Introduction: In many studies, immunogenicity of Brucella proteins such as P39 in animals is investigated. In this study, we evaluated antigenicity of recombinant P39 from Brucella abortus in patients with Brucellosis. Materials and Methods: In this experimental study, at first recombinant P39 was produced in Escherichia coli. Sera reactivity of six infected individuals against the recombinant P39 protein was analysed by Western Blot. Results: Data indicated that P39 protein from Brucella abortus was recognized by patients, sera antibodies. Conclusion: Our data showed that recombinant P39 protein can be detected as an antigen by sera in infected human. Therefore, recombinant P39 have same epitopes with natural form of this antigen.
Dr Ali Chehrei, Dr Manijeh Kahbazi, Dr Bahman Salehi, Dr Afsaneh Zarganj-Fard, Dr Fatemeh Darreh, Dr Parvin Soltani, Dr Ashraf Zamani, Dr Mohammad Khalili, Dr Afsaneh Noroozi,
Volume 9, Issue 2 (6-2006)
Abstract

Introduction: Performing correct research in different aspects of community as well as medical sciences can be a way to resolve many problems. In order to create a systematic knowledge of research method in academic members of Arak University of medical sciences and enabling them in providing proposals and performing researches, a clinical research center was developed. This study is done to investigate the effect of this center on improving clinical researches in the University. Materials and methods: This is a HSR, before and after, interventional study in which, clinical academic members of Arak University of medical science were evaluated. First the information of the pre intervention period was gathered (jan2002-jan2004). Then the intervention was done in the form of developing a research center in Vali-Asr hospital, performing serial research workshops, research conferences, research consultations and planning data bases during a 2 years period. Again data was gathered and then compared to those of pre intervention period. Results: The comparison of pre and post intervention periods showed that in pre intervention period from 38 proposals 30 and in post intervention period from 89 proposals 76 were approved by research committee of the University. In the two pre and post intervention periods 14(46.6%) and 50(65.8%) of accepted proposals were clinical respectively. Also from the view point of quality, 11 and 15 proposals were HSR, 2 and 22 clinical trials and 8 and 8 descriptive, respectively. The number of published articles in first period was 45 and in second 84. Presented articles in internal and external congresses were 33 and 59 in the two periods overally, which 25 and 51 articles were presented in the country and 8 and 8 in abroad congresses, respectively. Conclusion: Regarding the results it seems developing research center in this University and other similar Universities can have a significant effect on the process of clinical researches.
Dr Malak Soleimani, Dr Hedayat Sahraei, Dr Mehr Angiz Sadooghi, Ms Parisa Maleki,
Volume 9, Issue 2 (6-2006)
Abstract

Introduction: Investigations has showed that prenatal exposure to Morphine causes drug dependency and behavioral complications in new born rats. In this study effect of prenatal Morphine on the development of basal ganglia in rat embryos is investigated. Materials and Methods: In this experimental study 36 female rats with body weight between 250-300 grams were selected. After crossing with male rats they were divided into six groups of 12days control-Morphine, 14days control-Morphine and 17days control-Morphine groups. Morphine groups received 0.01mg/ml Morphine through their drinking water until the 12, 14 and 17th day of pregnancy (20ml each rat). Then rats were anesthetized and embryos were taken out and fixed. Their body weight and crown-rump length were measured. Then 5 micrometers sections were provided and stained using H & E method which were then evaluated using mutic program. Results: Body weight and length of embryos were reduced significantly in the 12&14th day of Morphine group rats in compare to their controls. The significant reduction of Basal Ganglia thickness was also found in all Morphine groups compared to their controls. Conclusion: Results showed that prenatal Morphine exposure may cause impairment in change development of Basal Ganglia.
Naser Mahdavi, Ali Ramazani, Mohammad Ali Shariatzade, Ali Moghimi, Malek Soleimani,
Volume 9, Issue 3 (9-2006)
Abstract

Introduction: One of the severe forms of affective disorders, defined in DSM-IV-TR, is bipolar disorder type1. This is a psychotic disease that coexists with structural and biochemical changes of CNS. It is probably under influence of environmental and/or genetic factors. Finger and hand prints are formed during the late first and second trimester of fetal development, and then remain unchanged. There are some suggestions that disturbance in dermatoglyphic patterns probably are in relation with appearance of bipolar disorder. It seems that this disturbance is appeared at the first and second trimester of fetal development, which is a critical period for CNS growth. This study is done to investigate the dermatoglyphic patterns in bipolar disorder. Materials and Methods: This is a case-control study in which we have studied the dermatoglyphic changes in 30 bipolar disorder patients and compared to those of 72 healthy controls. The χ2 test was used for quantitative and T-test for qualitative data analysis. Results: Results showed that TABRC in patients was decreased in comparison to healthy people but this decrease was not significant. Regarding the type of patients, fingerprints, Loop and Whorls forms were heterogenous and were significantly different in comparison to control group (p=0.001, p=0.003). Conclusion: It seems that dermatoglyphic patterns can be an interesting and probably suitable procedure in determining the prognosis of bipolar disorder type 1 and other psychiatric disorders.
Rezvan Ansari, Manije Kahbazi, Morteza Abdare Esfahani,
Volume 10, Issue 1 (3-2007)
Abstract

Introduction: Studies have shown that there is a relationship between metabolic syndrome and coronary heart disease. Hypertension is a common risk factor of both cardiovascular diseases and metabolic syndrome. The aim of this study is to determine the prevalence of metabolic syndrome phenotypes in patients with hypertension in Isfahan and Markazi provinces in center areas of Iran. Materials and Methods: This cross-sectional study was implemented in Isfahan and Markazi provinces in year 2001. Sampling method was random-clustering. 12514 people from both sexes who were above 19 years old were considered which based on ATP III, 1936 person of them had metabolic syndrome. Based on the definition, these people were those who at least had three of the following factors abnormally: HTN, FBS, TG, HDL and WC. Also hypertension was considered for all groups. Data was analyzed using Chi square test and Odds ratio. Results: The prevalence of metabolic syndrome was 0.6% to 7.5% in central areas of Iran. The most prevalent of metabolic syndrome was in hypertensive women with high TG and WC and the least prevalent was in hypertensive men with these two phenotypes: 1-high FBS and WC, and 2-high FBS and low HDL (p<0.05). Overall prevalence of metabolic syndrome in hypertensive people in the most of urban population was more than rural population. Conclusion: Results showed that hypertension is associated with different metabolic syndromes, especially in women with central obesity and dyslipidemia which necessitates more attention in preventing and treatment of the disease in this high risk group.

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