Showing 12 results for Malekirad
Akram Ranjbar, Hajar Rajabian, Yhya Jand, Elahe Mirza Zadeh, Akram Esmaili , Sara Ghasemi Nejad , Ali Akbar Malekirad,
Volume 7, Issue 3 (Autumn 2004)
Abstract
Introduction: Disturbance between production of free radicals and antioxidant defense is named oxidative stress. One of the main sources of free radicals is smoking that induce oxidative stress.
Materials and Methods: This is a cross sectional study in which questionnaires including information such as age, sex, education, history and number of smoking and history of special disease were filled. Case group were smokers (n=43) who were smoking at least 5 years and their mean age was 37.7 year. The control group was consisted of 43 nonsmokers which were matched for age and sex. They were evaluated for oxidative stress markers including thiobarbituric acid reactive substance (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total thiol (SH) groups and gammaglutamyl transferase (GGT) levels in blood.
Results: Results showed that induction of oxidative stress in smokers as revealed by decreased FRAP (1.89±0.03 vs 2.24±0.04, p=0.01) and plasma Sh groups (0.22±0.08 vs 0.81±0.48, p=0.01) in comparison to those of controls. The activity of GGT and level of LPO increased but were not significant . Also the correlation between history of smoking and oxidative stress was not significant.
Conclusion: It is concluded that smoking have decreased FRAP and SH groups which may put smokers at future consequences of oxidative stress. It seems that improving antioxidant system in smokers is effective.
Seyed Mahmod Tabatabaei, Mahmoud Reza Baghi Nia, Mansor Beirami, Ali Akbar Malekirad,
Volume 12, Issue 3 (10-2009)
Abstract
Abstract Background: Approximately 15-20% of pregnancies terminate to abortion. More than 50% of spontaneous abortions in 8-15 weeks pregnant mothers are related to genetically abnormalities. So, approximately 95% of them are related to numerical and 5% structural chromosome aberrations. Until now, neither of known human chromosomal abnormalities are treatable, and only way against these diseases limit to prenatal diagnosis and abortion of affected fetuses. The purpose of this study was determined the chromosome aberrations with cytogenetically methods. Materials and Methods: In this cross-sectional analytic study, 56 aborted fetuses were studied to detection of abnormalities frequency. Amnion-chorine culture, placenta, fetal tissue and aborted products from metaphase cells for gathering metaphase cells were used. Results: After cell culture, chromosome typing and GTG-banding Technique, trisomy 21 with highest frequency (12.5%) and isochromosomy 21, X and monosomy X with lowest frequency (1.8% for each them) was resulted. Conclusion: Not only chromosomal aberrations have important role in recurrent miscarriages, but also frequency rates of chromosomal aberrations in our country are similarity with other countries. Also cytogenetically diagnostic methods such as GTG-banding are a powerful and reliable technique for investigation of parents with recurrent abortion.
Gholamreza Chalabianloo, Mirtaghi Garooci Farshi, Ali Akbar Malekirad, Ali Hashemzadeh,
Volume 13, Issue 2 (6-2010)
Abstract
Background: Memory is one of the main functions that is impaired by neurological disorders. Noticing the susceptibility of memory to emotions, the effect of emotional states on memory in patients with alzheimer, brain tumor, and normal individuals was investigated in this study. Materials and Methods: Through Causal-Comparative study, 26 patients with alzheimer, 38 patients with brain tumor, and 30 normal individuals were selected and tested by a memory-related computerized task on explicit recall memory and implicit memory. Results: Patients with alzheimer showed a poor performance in memory tasks. They recognized more sad and threatening words in their explicit memory. Overall, patients with alzheimer and tumor in comparison with normal individuals indicated poorer explicit/implicit memory functions, respectively. Conclusion: Cognitive processes of patients with alzheimer are influenced when they encounter simple emotional stimulus.
Ali Akbar Malekirad, Ali Fani, Mohammad Abdollahi, Shahrbanoo Oryan, Vahhab Babapor, Seyed Mohhamad Ali Shariat Zadeh, Morteza Davodi,
Volume 13, Issue 4 (1-2011)
Abstract
Background: Lead (Pb) brings about a variety of cognitive, mental, renal, and blood system disorders by inducing oxidative stress. The aim of this study is to compare blood and urine parameters in the workers exposed to Pb and zinc (Zn) with those in the control group. Materials and Methods: An analytical cross-sectional study was conducted with a total number of 134 subjects. The case group included 67 male workers with the age range of 22-65 who had at least worked a minimum of one work shift for two years in the Zn-Pb mine located in the southwest of Arak, Iran. Control subjects consisted of 67 farmers of a village near the mine who had no history of occupational exposure to Pb, Zn, and other metals. Mental disorders were evaluated through the standard Scl-90-R while cognitive disorders were evaluated via the Mini Mental Status Examination (MMSE). Results: The mean level of blood and urine parameters did not reveal significant differences between the two groups. The mean scores of physical complaints, anxiety, and aggression scales were significantly higher in the case group than the control (p<0.05), whereas the mean scores on MMSE did not reveal a significant difference between the two groups. Conclusion: The oxidative stress of Pb led to mental disorders as a result, the mine workers suffered from more psycho- pathology and are in need of greater care. Due to the impacts of Pb and Zn, the proper use of safety equipments and taking daily showers can reduce the risk of absorption of toxic agents and their subsequent hazards for workers.
Seyed Mohhamad Ali Shariat Zadeh, Ahmad Hamta, Ali Akbar Malekirad, Shariat Zadeh,
Volume 13, Issue 5 (Supplement of Quran and Medicine 2011)
Abstract
Sleep is one of the basic needs of human and any disorder in its natural flow in addition to creating psychological problems can reduce the individual performance. There are descriptions and references about sleep and its features in Quran. In Naba Surش sleep has been referred to as a weakness that indicates a disease state. However, the conditions for the occurrence of sleep can be inferred from Kahf Sura, verse 11, which states: “a major quality of sleep is that one cannot estimate its duration”. In several other verses, sleep is said to be similar to temporary death. Substances such as endorphins, cortisol, and encephalin cause euphoria and have direct impacts on different parts of the body including skeletal muscles that lead to muscle comfort during the day. The amount of secretion of these materials into the body in the morning hours significantly increases. Therefore, waking up early in the morning can bring about euphoria and can have positive impacts which last till the end of the day. According to the findings released by the International Agency for Research on Cancer World Health Organization, men and women who work night shifts are at a greater risk of developing breast cancer and prostate cancer, respectively. Night sleep is a divine blessing that God has endowed people and God in verse 23 of Rome Sura refers to sleep as “one of the signs revealed to people” and asks people to search and investigate about it so as to realize to what extent night sleep can contribute to human perfection and success
Majid Ramazani , Seyed Mohamad Ali Shariatzade , Ali Akbar Malekirad , Ahmad Akbari , Mehdi Shariatzade ,
Volume 15, Issue 8 (January 2013)
Abstract
Background: Diabetes mellitus is one of the most important health problems in the world. B-cells are susceptible to damage by free radicals. Noticing the mechanism of cupping, this study was carried out to evaluate the effect of cupping together with drug therapy on biochemical factors and oxidative stress. Materials and Methods: In this clinical trial, 5ml of intravenous blood was obtained from diabetic patients in beginning and late stages of this disease who referred to a diabetes center. In addition to receiving metformin and glibenclamide, the patients underwent cupping after one month and were analyzed one month later. Blood samples obtained one month before and after the treatment were compared in terms of diabetes and oxidative stress indicators. To evaluate lipid peroxidation, TBA method was used and FRAPS method was employed to measure total serum antioxidants and blood factors by Pars Azmon kit. Results: Hemoglobin A1C, fasting blood sugar, blood sugar 2 hours after fasting, triglycerides, cholesterol, and low-density lipoprotein as well as high-density lipoprotein showed significant increases. Aspartate transferase in diabetic patients significantly decreased after phlebotomy (p<0.05). Conclusion: Cupping improves blood factors in diabetic patients and it is recommended to be used as a complementary treatment in patients with diabetes type II.
Ali Akbar Malekirad, Mohammad Abdollahi, Mohammad Fazilati, Najme Igani, Mahmod Reza Baghinia, Azam Taheri, Mohammad Amin Rezvanfar,
Volume 17, Issue 1 (4-2014)
Abstract
Introduction: Paints are composed of extensive variety of hazardous substances, such as organic solvents and heavy metals. Occupational exposure to paint increases oxidative stress, hematological disorders, and DNA injury. This study was performed to explore the beneficial effects of Selvit on the paint workers by measuring total antioxidant capacity, lipid peroxidation, and blood parameters as main oxidative stress biomarkers.
Materials and Methods: This clinical trial study was conducted on 25 male workers who worked in the paint factory. Serum markers such as total antioxidant capacity (TAC), lipid peroxidation (LPO) and also hematological parameters were measured before and after using Selvit (14 days). SPSS software was used for data analyses and paired t-test and Pearson correlation analysis were applied.
Results: Results showed that after using the Selvit, an increase in TAC and a decrease in LPO were observed but they were not significant. Also, aspartate transaninase significantly decreased after using Selvit and high density lipoprotein significantly increased.
Conclusion: Selvit have beneficial effect on hematological parameters due to its antioxidant capacity.
Azam Afaghi, Shahrbanoo Oryan, Mohammad Abdollahi, Kobra Rahzani, Aliakbar Malekirad, Hossein Kakooie,
Volume 17, Issue 7 (10-2014)
Abstract
Background: The current paper set out to investigate the level of asbestos fiber and asbestos body in sputum and assayed of haematological factors, liver enzymes and pulmonary function test in asbestos exposed group.
Materials and Methods: An analytical cross-sectional study was conducted with a total number of 100 subjects. The case group included 50 male workers with the age range of 25-60 who had at least worked for five years in the asbestos-cement factory. Control subjects consisted of 50 people who had no history of occupational exposure to asbestos. Lung function tests were measured with a portable calibrated vitalograph-PFT spirometer. liver enzymes were assayed with Pars Azmoon kits. Counts of red blood cells and white blood cells were assayed with a cell counter. We used light polarizan microscope to study the level of asbestos fiber and asbestos body in sputum.
Results: Asbestos fiber observed in sputum sample of workers and type of asbestos fiber is chrysotile. Asbestos bodies were found in only 10% of the workers. Decrease (but not significant) in lung function factors (FVC, FEV1, FVC/FEV1) had been seen in the workers in compare with control group. WBC, Eosinophil, neutrophil, lymphocyte, monocyte and liver enzymes levels were significantly higher (but in normal range) in workers as compared with the control group.
Conclusion: Presence of asbestos fiber and asbestos body in workers sputum samples showed workers exposure to asbestos and reduced level (insignificant) of lung function factors and increased level of leukocyte may be indicated pulmonary inflammation. These results also suggested that occupational exposure to asbestos dust may perturb liver mal function parameters
Neda Baghinia, Gholam Hassan Vaezi, Ali Akbar Malekirad, Mahmood Reza Baghinia,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Nickel and chromium are heavy metals whieh after arriving in biological systems can produce highly reactive free radicals in the body and interact with macromolecules cause damage to them. The purpose of this study, the effect of bilberry and cinnamon extract on blood biochemical factors in workers exposed to nickel and chromium.
Materials and Methods: In this clinical trial, 99 workers were divided into 3 groups: group 1 (control), group 2 workers, welders exposed to nickel and chromium without extract (G) and group 3 workers, welders exposed to nickel and chromium with extracts (B). First biochemical parameters were measured in blood serum. Then the group 3, 2 times a day for four weeks, billberry juice and tea - Cinnamon received. Finally, Biochemical parameters in blood were measured and compared. SPSS software and descriptive statistics (mean±SD), T- independent and one-way ANOVA test were used to analyze the data.
Results: Between group Variance in some biochemical variables between the three groups, control, G and B showed statistically significant differences (p<0.05). Within-group variance was significant in some variables.
Conclusion: After consumption of billberry juice and tea-cinnamon positive changes in biochemical parameters in workers who are exposed to the toxic effects of nickel and chromium was obtained.
Saeid Amini Rarani, Ahmad Ghadami, Ali Akbar Malekirad, Hojatollah Yousefi, Kourosh Mani,
Volume 19, Issue 10 (1-2017)
Abstract
Abstract
Background: Operating room personnel are subject to occupational hazards which could lead to an increase in free radicals and develop various diseases. The aim of the present study was to determine the effect of consuming green tea on the improvement of the blood oxidative biomarkers in operating room personnel who are exposed to anesthetic gases.
Materials and Methods: This study was a before-after clinical trial which was conducted on 24 operating room personnel. They were invited to consume 4 cups of a green tea beverage, prepared from 3 g of green tea leaves in 300 mL of boiled water (at 80˚ C), daily for 8 weeks. Then, Myeloperoxidase (MPO), DNA damage, Glutathione Peroxidase (GPx), and Superoxide Dismutase (SOD) in the plasma were measured in order to evaluate the level of oxidative stress biomarkers before and after consuming green tea.
Results: Green tea consumption by operating room personnel brought about a significant increase in glutathione peroxidase and superoxide dismutase and a considerable decrease in myeloperoxidase and DNA damage.
Conclusion: According to the results of this study, green tea consumption as an antioxidant supplement by operating room personnel, who are regularly exposed to anesthetic gases, can minimize oxidative stress and DNA damage considerably. Thus, it is advisable for operating room personnel to consume green tea as a natural antioxidant supplement.
Ali Asghar Ghafarizadeh, Gholamhassan Vaezi, Seyed Mohammad Ali Shariatzadeh, Ali Akbar Malekirad,
Volume 20, Issue 6 (9-2017)
Abstract
Abstract
Background: In Asthenoteratozoospermic men, low motility, defected DNA and highly oxidative stress in sperm cause poor assisted reproductive techniques (ART) outcomes. The aim of this study was to determine the effect of Vitamin E (Vit E), as a potent antioxidant, on sperm motility, viability and DNA integrity at different times of in vitro incubation (after 2, 4 and 6-h) to improve asthenoteratozoospermic semen samples for ART.
Materials and Methods: Asthenoteratozoospermic semen samples of 50 volunteers were collected and examined. Each sample was divided into two groups of control and vitamin E (2mM) and kept in the 37 °C and 6 % CO2 for 2, 4 and 6 hours. After this incubation, sperm motility, viability and sperm DNA fragmentation (SCD) were evaluated in each group. Data were analyzed using repeated measurement of ANOVA and T-test. The means were considered significantly different at p<0.05.
Results:Significant decrease in total and progressive motility and viability as well as significant increase in sperm DNA damage (after 6h of incubation) were found in control group vs. the control group before incubation (p<0.05). The sperm motility and viability was significantly higher in vitamin E group compared to untreated control group (p<0.05). Our results also showed that DNA fragmentation significantly was lower after 6h of vitamin E treatment (p<0.05).
Conclusion: In vitro supplementation of vitamin E in asthenoteratozoospermia semen samples may protect spermatozoa from maltreatment effect of ROS during sperm sampling via keeping enzymatic and antioxidant process in optimum condition.
Arezoo Fathi, Ahmad Alipour, Aliakbar Malekirad,
Volume 26, Issue 2 (June & July 2023)
Abstract
Introduction: Infertility is one of the bitter events of married life that has various psychological consequences. On the other hand, there are different treatments to reduce its psychological effects. The purpose of this research was to compare the effectiveness of emotion-focused couple therapy and Gottman couple therapy on marital burnout and depression in infertile couples.
Methods: The present research method was semi-experimental with a pre-test-post-test design with a control group. The statistical population of this research included infertile couples of Arak city in 1400, of which 54 couples were selected using available sampling method and 18 couples were randomly assigned in three groups (two experimental groups and one control group). The experimental intervention groups received emotion-focused couple therapy (10 sessions of 90 minutes) and Gottman couple therapy (10 sessions of 90 minutes), and the control group did not receive any intervention. After two months, the follow-up phase was done. In order to collect data, Beck's (1967) depression questionnaire and Pines' (1966) marital burnout questionnaire were used, and the data were analyzed using repeated measures analysis of variance and SPSS version 26 software. This research is approved by the ethics committee with the code IR.IAU.B.REC.1400.026. Also, the principles of confidentiality, written informed consent and destruction of participants' information have been observed.
Results: The results showed that Gottman couple therapy and emotion-focused couple therapy reduce couples' depression (2 = 0.265, P = 0.001, F = 18.94) and marital burnout (2 = 0.348, P = 0.001, F = 27.99) has been effective. In addition, emotion-focused couple therapy has been more effective in reducing couples' depression (p=0.033) and marital burnout (P=0.001) than Gottman's couple therapy.
Conclusions: According to the results of the research, it can be said that emotion-focused couple therapy is more effective than Gottman's couple therapy in reducing couples' depression and marital exhaustion. Therefore, couple therapists are advised to use emotion-focused couple therapy to improve depression and marital burnout of infertile couples.
