Journal of Arak University of Medical Sciences

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Showing 2 results for Malekafzali

Goiter Survey and Urinary Iodine Concentration in School Children Aged 8 to 10 Year of Markazi Province in 1996

Fereydoun Azizi, Robabeh Sheikholeslam, Parvin Mirmiran, Gita Abdolhosini, Masoud Kimiagar, Hossein Malekafzali,
Volume 4, Issue 3 (Autumn 2001)

Abstract

Introduction: Iodine deficiency disorders (IDD) is a worldwide health problem. Many parts of the Islamic republic of Iran had been known as areas of endemic goiter. IDD was accepted as a priority health problem in the country and a National IDD Council was formed in 1989.
Material and Method: One of the main strategies of National Council for IDD control was to provide at least 150mg of iodine per day to the entire population through making available iodized salt. This study was performed to evaluate the National IDD council program in 1996, in rural and urban areas of Markazi province, 1300 school children, aged 8 to 10 years, including 50% boys, were selected through random sampling Grading of goiter was performed according to WHO. Classification, Serume, T3, T4 and TSH were measured by RIA and urinary iodine by digestion method.
Results: The mean of serume T3, T4 and TSH were: 10±2.0 μg/dl, 160±28 ng/dl and 2.3±1.3 μIu/ml respectively. There were no differences between males and females and school children of rural or urban areas. Four person had serum T4 more than 12.5μg/dl. The mean urinary iodine was 16mg/dl in entire population. 75% had urinary iodine more than 10mg/dl. Only 11% had urinary iodine less than 5μg/dl. Total prevalence of goiter was 35% (36% in girls and 34% in boys).
Conclusion: Based on the available data, seven years after distribution of iodized salt, urinary iodine of school children of Markazi province does not show iodine deficiency. However goiter is still endemic in Markazi province.

The Effect of Air Pollution on γ-Glutamyltransferase Enzyme Activity

Nushin Rezaee Vandchali, Mojtaba Fathi, Ali Koolivand, Sheida Malekafzali, Farideh Jalali Mashayekhi,
Volume 19, Issue 10 (1-2017)

Abstract

Abstract

Background: Human exposure to air pollution is associated with an increased risk of diseases such as heart failure, asthma and cancer. It has been suggested that oxidative stress is involved in air pollution-induced disorders. Recently, γ-glutamyltransferase (GGT) is known as a marker of oxidative stress. This study was aimed to evaluate the effect of exposure to outdoor air pollution on enzyme activity of GGT and also usage of GGT serum level as a marker for studying of harmful effects of air pollution in the resident with high air pollution level.

Materials and Methods: In this analytical cross-sectional study, 110 healthy adult men, never-smoking, who worked in an area with high air pollution and 90 men who worked in an area with low air pollution, as control group, were enrolled. All subjects were in the age range of 25-45 years with minimum work history of three years. The GGT activity in the serum samples was determined using a spectrophotometric method.

Results: Our results showed that the serum levels of GGT in the subjects in the areas with high air pollution (33.92 ± 1.61 U/L) did not differ significantly with those of control region (33.62 ± 1.74 U/L).

Conclusion: Overall, this study did not support the hypothesis that GGT enzyme could be considered as an oxidative stress marker following exposure to outdoor air pollution. Further studies with a larger sample sizes and also trials in other areas are required to confirm these results.

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