Journal of Arak University of Medical Sciences

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The effect of N-Acetylcysteine on the reduction of permanent noise-induced hearing loss in workers at Hepco Company

Abolfazl Jafari, Reza Badiei, Maryam Yarmohammad Tooski, Behieh Kohansal,
Volume 14, Issue 5 (11-2011)

Abstract

Background: Noise-induced hearing loss is a noticeable clinical issue. The aim of this study was to evaluate the effect of N-Acetylcysteine on the reduction of permanent noise-induced hearing loss in workers at Hepco Company. Materials and Methods: In this clinical trial, in a one-month period from October to November, 118 male 22-52 year-old workers with at least 5 years of experience working in places with permanent high tone noise (more than 850db) were selected and divided to experimental and control groups. The experimental group received Fluimucil (NAC) and the control group received vitamin B1. Hearing ability of the two groups was evaluated through audiometry after the one-month period. Results: In the control group, hearing loss was significant and it was in direct relationship with age and job experiment. The placebo (vitamin B1) did not have any significant effects on preventing hearing loss. In the experimental group, there was significant hearing loss in higher frequencies and at 6000, a relative improvement was observed, whereas with increases in age and job experience hearing loss became more significant which was rather low in comparison with the control group. Conclusion: The findings of this study shows that using N-Acetylcysteine has significant effects on NIHL (high tone loss) in higher frequencies. This study can be used as the basis for launching future studies on reducing the damages induced by noise

The Association of rs2910164 Polymorphism in mir-146a Gene with Obesity in Iranian Women

Amir Hossein Hosseini, Leila Kohan, Sara Fallahi,
Volume 18, Issue 8 (11-2015)

Abstract

Background: Obesity is a complex, multifaceted disease resulting from a combination of genetic, environmental, and lifestyle backgrounds, and is associated with increased risk of diseases, such as hypertension, dyslipidemia, and type 2 diabetes. MiRNAs have been reported to be associated with chronic diseases such as obesity. The present study is the first investigation that examines the possible association of rs2910164 polymorphism in mir-146a gene with overweight and obesity in Iranian women.

Materials and Methods: This case-control study was conducted on 133 overweight, 75 obese and 173 healthy control women with normal weight. The rs2910164 polymorphism genotypes of mir-146a gene were determined by the Tetra-ARMS PCR method. Also, logistic regression analysis was used to estimate the association between genotypes and obesity risk.

Results: There was a significant association between GC (OR: 1.8, 95%CI: 1-3.3, p: 0.04) and CC (OR: 4.5, 95%CI: 1.6-12.6, p: 0.004) genotypes with susceptibility to obesity. In the dominant genetic model of the C allele (comparison between CC+GC vs. GG), CC+GC genotypes were associated with the risk of obesity (OR = 2.1, 95% CI: 1.2–3.7, p= 0.01).

Conclusion: This study showed that mir-146a gene rs2910164 polymorphism is associated with obesity risk and the C allele may act as a dominant allele and increase the obesity risk in Iranian women.

Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome

Samira Heidarpanah, Leila Kohan, Seyedeh Sara Hashemi,
Volume 19, Issue 10 (1-2017)

Abstract

Abstract

Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several studies have shown a possible role of Fas in ovarian apoptosis. The present study is the first investigation to examine the possible association of Fas rs1800682gene polymorphism with PCOS risk in Iranian women.

Materials and Methods: This case-control study was conducted on 251 patients with PCOS and 213 healthy control women. The Fas rs1800682 gene polymorphism genotypes were analyzed using the Tetra-ARMS-PCR method. Also, logistic regression analysis was used to investigate the association between genotypes and PCOS risk.

Results: There was a significant association between A allele and susceptibility to PCOS(OR =1.4, %95CI=1.08-1.83, p=0.011). Moreover, in the recessive genetic model for A allele, the AA genotype increased the risk of PCOS after adjusting age and body mass index(OR=1.6, %95CI=1.02-2.51, p=0.041).

Conclusion: For the first time, this study showed that Fas rs1800682 polymorphism is associated with PCOS risk in Iranian women and the A allele may act as a recessive allele for increasing the risk of PCOS.

Association of HSPA1B rs6457452 Genetic Variant with Idiopathic Male Infertility

Elahe Kohan, Leila Kohan, Maryam Maghbol,
Volume 20, Issue 8 (11-2017)

Abstract

Abstract
Background: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Spermatogenic Failure accounts for more than half of male infertility cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1B rs6457452 genetic variants in male infertility.
Material and Methods: This case control study was conducted on 516 subjects consisted of 308 patients with idiopathic male infertility and 208 control subjects. After DNA extraction from peripheral blood, genotype determination was done by Tetra-ARMS PCR method. Logistic regression analysis was used to estimate the association between the polymorphism and male infertility.
Results: A significant difference was observed in genotype distributions between cases and controls. Results showed individuals with TC (OR=1.552, 95%CI: 1.032-2.334, p=0.035) and TT (OR=2.746, 95%CI: 1.153-6.545, p=0.023) genotype had an increased risk of male infertility. Also, there was a significant association between T allele (OR=1.695, 95%CI: 1.220-2.355, p<0.001) and male infertility.
Conclusion: This study showed for the first time that HSPA1B rs6457452 polymorphism is associated with infertility risk in Iranian men and the T allele may act as a dominant allele for increasing the risk of male infertility.

The Effectiveness of Filial Therapy on Social Acceptability and Anxiety Sensitivity of Children with Symptoms of Self-Harm Disorder

Miss Shahrzad Adili, Miss Zohreh Raeisi, Miss Nahid Akrami, Miss Zohreh Ranjbarkohan,
Volume 26, Issue 3 (August & September 2023)

Abstract

Introduction: The present study was conducted with the aim of the effectiveness of philial therapy on social acceptability and anxiety sensitivity of children with symptoms of self-destructive mood disorder.
Methods: It was a semi-experimental study with a pre-test-post-test design with a control group and a follow-up period. The statistical population included 9-12-year-old children with symptoms of suicidal mood disorder in Isfahan city. 30 children with symptoms of self-inflicted mood disorder and their mothers were selected by purposive sampling and randomly assigned to experimental and control groups. The experimental group received Filial Landreth play therapy intervention (2013) during two months in 8 sessions of 60 minutes. Research tools included Ford and Robin's (1970) social acceptability questionnaire and Tsao et al.'s (2006) anxiety sensitivity questionnaire. The data obtained from the research was analyzed by the method of variance analysis with repeated measurements using SPSS-29 statistical software.
Results: The results showed that the filial therapy intervention had a significant effect on the social acceptability and anxiety sensitivity of children with symptoms of self-destructive mood disorder (P<0.001). In this way, this intervention was able to lead to the improvement of social acceptability and the reduction of anxiety sensitivity of these children.
Conclusions: Based on the findings, it can be concluded that philial therapy using techniques such as lectures, discussion, role playing, group processes and supervision can be an effective treatment to improve social acceptability and reduce anxiety sensitivity of children with the symptoms of self-inflicted mood disorder should be used.

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