Showing 8 results for Kiani
Ali Asilian, Masoud Farinam, Asadollah Kiani,
Volume 5, Issue 4 (Winter 2002)
Abstract
Introduction: Basal cell carcinoma is the most common malignancy in humans. A number of treatment modalities are available. We performed this study in order to determine the efficacy of Mohs micrographic surgery in treatment of basal cell carcinoma.
Materials and Methods: This retrospective descriptive study was performed on 194 basal cell carcinoma (in 175 patients) were treated in Isfahan Al-Zahra Hospital from september 1999 to March 2003 with Mohs micrographic surgery. Data were obtained from patient's files and were analized by SPSS software.
Results: Of the 175 patients (with 194 basal cell carcinomas), 110 (62.85%) paticnls were male and 65 patients (37.14%) were females. The mean age of patients was 58±12.38 years. The majority of tumors were located on face and scalp. 180 of tumors were primary and 14 were recurrences. 17% of tumors were larger than 2cm. Recurrences of the tumor occured in 3 patients. The cosmetic results were excellent and good in 81%. The incidence of recurrnce rate was 0.9%.
Conclusion: Kecurrence rate is low when basal cell carcinomas treated with micrographic surgery so this treatment modality (when indicated) is also strongly recommended in Iran for the treatment of basal cell carcinoma.
Farba Kiani, Hossein Samavatyan, Siamak Poorabdian,
Volume 15, Issue 1 (April-May 2012)
Abstract
Background: A lot of research has been done on the post-traumatic stress, but few studies have investigated the effect of chronic stress disorders on physical and psychological health. This study investigated the combined interactive effects of chronic stress disorders and mental disorders on somatoform disorders reporting among employees at Isfahan Steel Company.
Materials and Methods: In this correlational study, 189 employees in Isfahan Steel Company wwere selected according to the stratified random sampling method and completed demographic characteristics, chronic stress disorders of Cohen, Karmark, and Mermelstein, and mental disorders and somatoform disorders of Barling, Loughlin, and Kelloway questionnaires in 2011. Data were analyzed using Pearson correlation coefficient and hierarchical regression.
Results: Results showed significant internal correlations among chronic stress disorders, mental disorders, and somatoform disorders (p<0.01). In addition, by controlling for demographic variables, the results of hierarchical regression analysis showed the interactive effect of chronic stress disorders and mental disorders on reporting somatoform disorders to be significant (p<0.05).
Conclusion: This study showed that chronic stress disorders have a positive relationship with reporting somatoform disorders both in experiencing and not experiencing psychological disorders however, this relationship was stronger when employees in addition to chronic stress disorders experienced psychological disorders.
Behnaz Tavasoli, Saber Ebrahimi, Rima Manafi, Fatemeh Kiani, Majid Safa, Ahmad Kazemi,
Volume 17, Issue 7 (10-2014)
Abstract
Background: Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. Currently, chemotherapy is the most effective method of leukemia cancer treatmentwhich has many side effects. New strategies in cancer therapy utilizecompounds that specifically target aberrant signaling pathways in order to reduce toxic sideeffects Indole-3-carbinl (I3C) found in vegetables has multiple anti-cancer properties because of its ability to modulate multiple cellular signaling pathways. In this study the molecular mechanism of the action of indole-3-carbinol on pre- B ALL cells was investigated.
Materials and Methods: In current study, NALM-6 cells were treated with different concentrations of I3C at specific times. Analysis of cellular DNA content was performed by flow cytometry for evaluation of cell cycle status. The protein expression of p21, p53 as well as c-Myc proteins was determined by Western blot in I3C-treated cells.
Results: Cell cycle histogram analysis showed that I3C significantly increased the percentage of G1 cells compared with non-treated cells (control)(p<0.05). The western blot analysis also indicated I3C significantly up regulated p21, p53 expression and down regulated c-Myc expression (p<0.05).
Conclusion: The G1 arrest induced by I3C is associated with down-regulation of c-Myc and up-regulation of p53 and its downstream target p21.
Behnaz Tavasoli, Rima Manafi, Fatemeh Kiani, Majid Safa, Ahmad Kazemi,
Volume 17, Issue 11 (2-2015)
Abstract
Background: Doxorubicin is a chemotherapeutic agent still in widespread use in hematologic malignancies. A side effect of anthracyclines such as doxorubicin is the activation of nuclear factor-&kappaB (NF-&kappaB), a potent inducer of antiapoptotic genes, which may blunt the therapeutic efficacy of the drugs. In this study, the effect of indole -3-carbinol (I3C) on the activation NF-&kappaB and the anti-apoptotic genes whose expression is regulated by NF-&kappaB was assessed in NALM-6 cells.
Materials and Methods: NALM-6 cells were preincubated with various concentrations of I3C and then treated with doxorubicin. Cellular DNA content assay and Annexin V-FITC staining were performed by flowcytometry for evaluation of apoptosis. For assessing the effect of I3C on the expression of XIAP, survivin, and nuclear p65 proteins, NALM-6 cells were pretreated with I3C and then incubated with doxorubicin. Whole-cell and nuclear extracts were prepared for Western blot analysis. A paired t-test was conducted to evaluate the results.
Results: DNA histogram analysis of NALM-6 cells indicates a combination of I3C with doxorubicin significantly escalated the percentages of sub-G1 population cells compared with doxorubicin - only treated group (p<0.05). Annexin V-FITC staining also showed that cotreatment of NALM-6 cells with I3C and doxorubicin significantly increased the proportion of Annexin-V positive cells in comparison with the doxorubicin treated cells (p<0.05). The western blot analysis indicated I3C significantly inhibits both doxorubicin -induced nuclear translocation of p65 and the expression of doxorubicin-induced NF-&kappaB target.
Conclusion: Our results indicated that using natural non-toxic inhibitors of NF-&kappaB such as I3C in combination with anthracyclines might be a rational combination therapy for BCP-ALL cells in which NF-&kappaB is constitutively active.
Sholeh Zakiani , Saied Ghaffari ,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: Promoting spiritual intelligence and adherence to ethics leads to higher quality service, efficiency and effectiveness. The present study was conducted to investigate the relationship between the spiritual intelligence of librarians and the quality of services in the libraries of Shahid Beheshti University of Medical Sciences with a professional ethics approach.
Materials and Methods: The research method was descriptive-correlational and with an objective purpose. The statistical population included 180 librarians working in the library of Shahid Beheshti University of Medical Sciences. Data collection was done by two questionnaires of King and Radad. Data analysis was done by inferential methods and Kolmogrov-Smirnov test. Data were analyzed by SPSS version 22 software.
Ethical Considerations: In this study, all principles of research ethics were considered.
Findings: The results showed that there is a positive and significant relationship between the dimensions of spiritual intelligence(critical existential thinking, production of personal meaning, transcendental consciousness, and extension of consciousness) and the quality of services in the libraries.
Conclusion: The result of the research showed that there is a relationship between the spiritual intelligence of librarians and the provision of quality services in the libraries of Shahid Beheshti University of Medical Sciences with the professional ethics approach. Therefore, using the spiritual intelligence, service quality in the studied libraries could be increased.
Yousef Panahi, Davood Kiani Fard, Fatemeh Feyzi,
Volume 22, Issue 6 (February & March 2020)
Abstract
Background and Aim: The purpose of this study was to investigate the stimulatory and protective effects of Methylphenidate (MPD) on the experimental epilepsy induced by intraperitoneal injection of Pentylenetetrazole (PTZ) in adult male rats.
Methods & Materials: In this study, 15 male rats (weight, 200-250 gr) dividied into one control group (n=5) received normal saline and two treatment groups; the first group (n=5) received MPD with a dose of 2.5 mg/kg and the second group (n=5) received MPD with a dose of 5 mg/kg by gavage. After anesthesia with ketamine-xylazin combination and animal skull surgery, the recorded electrodes were inserted into the cranium in the stratum striatum layer of the CA1 region of the hippocampus, and epileptic activity was induced by intraperitoneal injection of PTZ (80 mg/kg) and the epileptiform activity was evaluated in terms of the number of spikes per time unit and their amplitudes by eTrace software.
Ethical Considerations: This study with an ethics code of FVMT.REC.1397.67 was approved by the Research Ethics Committee of the Faculty of Veterinary Medicine at University of Tabriz.
Results: Oral MPD at 2.5 and 5 mg/kg doses increased the number of spikes up to 576 and 613, respectively, compared to the control group (330 spikes), which were statistically significant. Amplitude of PTZ-induced epileptic activity after treatment with 2.5 and 5 mg/kg MPD reached 1254 and 1085 respectively compared to control group (1051), which were not statistically significant.
Conclusion: The doses of oral MPD used in this study potentiate seizure activity. Therefore, the use of this drug in people with a background of seizure or suffering from some types of seizure should be cautious, and the evaluation of its effect in these patients need further studies.
Ali Esfahani, Shirin Zeinali, Roghayeh Kiani,
Volume 23, Issue 2 (June & July 2020)
Abstract
Background and Aim: Breast cancer is the most common cancer among women which leaves a profound impact on their psychosocial health and pain experience. The aim of this study was to determine the effect of group psychotherapy based on Acceptance and Commitment Therapy (ACT) on pain-related anxiety and cognitive emotion regulation of women with breast cancer.
Methods & Materials: In this quasi-experimental study, subjects were 68 women with breast cancer refereed to Shahid Ghazi Hospitalin Tabriz, Iran who were selected using a convenience sampling method. Then, they were randomly assigned into two groups of intervention (n = 34) and control (n = 34). The intervention group underwent eight 90-min sessions of ACT-based group therapy, while the control group received no any intervention. They completed Pain Anxiety Symptom Scale Short Form and Cognitive Emotion Regulation Questionnaire before and one week after treatment. Collected ata were analyzed by using t test, chi-square test, ANCOA and MANCOVA.
Ethical Considerations This study has obtained its ethical approval from the Research Ethics Committee of Tabriz University of Medical Sciences (code: IR.TBZMED.REC.1397.287) and has been registered by Iranian Registry of Clinical Trials (code: IRCT2017100615590N5).
Results: The ACT-based intervention improved the dimensions of pain-related anxiety (8.44±1.5) and cognitive regulation of negative (8.40±3.5) and positive (8.39±7.5) affects (P<0.001).
Conclusion: ACT-based intervention can help breast cancer patients to accept their negative thoughts and current conditions.
Dr Azadeh Khazaei Zadeh, Dr Afrooz Nakhostin, Dr Mahsa Kianifar,
Volume 26, Issue 5 (December & January 2023)
Abstract
Introduction: The academic failure of students is one of the major problems of higher education centers in the country, which not only wastes time and running costs of these centers, but also causes mental-psychological, family and social problems for students. The purpose of this study was to investigate and explain the various causes of academic failure in dental students of Arak city.
Methods: The present study was of a descriptive-analytical type, which was conducted with the participation of 120 dental students of Arak Medical Sciences. Sampling was by census method and all students were included in the study. The data collection tool of this study was a questionnaire containing demographic characteristics, questions related to various factors of academic failure in students. Data were analyzed using descriptive and inferential statistical methods (frequency, mean, standard deviation, Pearson correlation coefficient and linear regression) in SPSS software version 22.
Results: The sample consisted of 30 individuals (10 males and 20 females) with generalized anxiety disorder, selected purposefully and randomly assigned to a treatment group based on virtual reality and mindfulness (15 individuals) and a control group (15 individuals). Pre-test, post-test, and follow-up cortisol levels were measured, and the Generalized Anxiety Disorder 7-item scale (GAD-7) was used as the entry criterion. Subsequently, the experimental group received an eight-session, 17-minute weekly treatment based on virtual reality and mindfulness. Participants in this group, while immersed in a virtual environment, watched 360-degree virtual reality videos, "Walking by the Beach" and "Pebbles in the Lake," accompanied by mindfulness audio contemplation, "Being Present and Breathing," and "Wise Mind," using a VR headset and VR-ARBOX. The control group received no treatment.
Conclusions: According to the findings of this research, it was found that factors such as student's individual characteristics, inappropriate educational environment, inappropriate family environment and dealing with non-curricular issues had a significant effect on the event of students' academic decline, so paying attention to these factors in the design and implementation University educational programs can play an effective role in avoiding academic failure.
