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Saeid Changiz Ashtiani, Saeid Khameneh, Hamid Salimi Khaligh,
Volume 2, Issue 7 (Summer 1999)
Abstract

Arterial  baroreflexes are the most important mechanism of cardiovascular control. These reflexes compared with other reflexes act so rapidly that can respond to rapid blood pressure changes during daily activities. In this study we have assessed the cardiac responses of cardiac baroreflexes dynamic exercise , and compared the results with acute response during rest exercise. It was 50% of calculated maximum force. Experiments were performed on 12 young male healthy sedentary volunteers isometric exercise(protocol B) and dynamic exercise (protocol C). In order to stimulate the carotid baroreceptors neck suction device Eckberg model was used , ECG were taken continuously during experiment. In protocol A (control group) after stimulation the cardiac cycle (R-R interval) from baseline reached to acute responses in the first beat induction baseline in the forth beat P<0.003 and in the protocol C reached acute response compared with baseline in the eighth beat after induction P<0.001. If the observed acute responses during test are compared and concluded that shorting R-R interval in response to isometric due to vagal withdrawal combined with an subtle sympathetic stimulation. This phenomenon is observed more strongly in dynamic exercise.

Saeid Changizi Ashtiyani , Saeid Khameneh, Hamid Salimi Khaligh ,
Volume 3, Issue 2 (Summer 2000)
Abstract

Arterial baroreflexes are the most important mechanism of cardiovascular system that can respond to rapid blood pressure changes during everyday activities. In this study we have assessed adaptive responses of carotid baroreflexes during isometric & dynamic exercise and compared the results with acute response during rest. The applied work loud in dynamic exercise was 100 watts and in isometric exercise it was 50% of calculated maximum force. Experiments were performed on 12 young male healthy sedentary volunteers aged between 21-28. This study was done in three exercises. In all three protocles, adaptation process during stimulation was assessed by studying of beat to beat R-R interval of ECG. In order to stimulate the carotid baroreceptors neck suction device Eckberg model was used and duration of stimulation was 10 seconds. ECG was taken carefully. Examination of adaptive process during stimulation showed maximal response achieved in resting state is statistically significant compared with that of isometric and dynamic exercise respectively (P<0.038, P<0.007). where as, comparison of adaptive response of rest state with isometric exercise and dynamic exercise was not statistically significant. There is no significant relation between maximal and adaptative response in dynamic and isometric exercises, although in general adaptative process in resting state compared with isometric and dynamic exercise was more pronounced. This observation confirmed that Vagal withdrawal with alimited degree of sympathic stimulation are challenged in this phenomenon. In other words the Sa response to vagal stimulation is related by sympathic stimulation.

Saeed Changizi Ashtiani, Saeed Khameneh , Nahid Ghandechilar,
Volume 5, Issue 2 (Summer 2002)
Abstract

Introduction: The  off  response  of  baroreflex  is  mostly  ignored  by  recent  studies.  In  the  present  study  we  aimed  at  assessing  this  during  rest, and  isometric  and  dynamic  exercise.
Materials  and  Methods: 12  young  male  subjects  volunteered  the  study. Using  an  Eckberg  neck  suction device  each  subject  received  a  brief  (10  sec).  about  of  sustained  stimulus  with -50 mm  Hg  pressure  in  the  neck  chamber.  The  workload  incorporated  was  100w  for  dynamic  and  50%  of  maximal  effort  for  isometric  exercise. Electrocardiogram  was  recorded  on  line  R-R  intervals  were  assessed  beat   and  responsed  cardiac  response. This  was  significant  at  all  three  states.
Results: on  the  average, the  peak  off-response  tachycardia  occurred  earlier (3rd  sec).  in  exercise  tests  as  compared  with  that  of  rest (5th  sec). the  intensity  of  tachycardia  was  more  prominent  at  rest, isometric  exercise, and  dynamic  exercise, respectively  and  the  difference  between  rest  and  dynamic  exercise  gained  significance (p<0.01).
Conclusion: The  attenuation  of  so  called  post  vagal  tachycardia  during  exercise  is  in  accordance  with  the  assumed  reduction  of  vagal  tone  during  exercise.

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