Bita Kaviani, Hossein Sazegar, Noosha Zia-Jahromi, Farzane Mohamadi Farsani,
Volume 20, Issue 11 (2-2018)
Abstract
Abstract
Background: The aim of this study is to investigate the role of rs137852599 single-nucleotide polymorphism in the androgen receptor coding gene on drug resistance against treatment with Enzalutamide in individuals diagnosed with prostate cancer.
Materials and Methods: In this case-control study, the ARMS-PCR analysis was conducted on androgen receptor coding gene in 50 patients diagnosed with prostate cancer with drug resistance and on 50 patients diagnosed with prostate cancer without drug resistance. The statistical analyses were performed using the GeNePop server and then the results were investigated by the SISA server.
Results: The allele frequencies of A and C alleles in rs137852599 were 0.78 and 0.22 for drug resistant and 0.94 and 0.06 for non-drug resistance groups. The results indicated that there is a meaningful relationship between drug resistance and rs137852599 single-nucleotide polymorphism
(p = 0.020).
Conclusion: The existence of single-nucleotide polymorphisms may result in drug resistance in individuals diagnosed with prostate cancer. Therefore, investigation of the existence of such polymorphisms can be effective in prescription of suitable drugs for these patients.
Atefeh Sadeghi, Hadi Hasani, Mobina Kaviani, Ramin Mohammadi,
Volume 28, Issue 5 (12-2025)
Abstract
Introduction: With the advancement of science and knowledge worldwide, ethical challenges are increasing, and nurses' inability to face these challenges significantly impacts the quality of healthcare. Moral courage in nurses helps overcome fear and unethical values. The complexity of nursing work affects spiritual health and prevents nurses from adapting well to nursing challenges.
Methods: This was a correlational study using a convenience sampling method. In 2024-2025, nurses working at Amirul Mominin Hospital were selected, with a calculated sample size of 221. The instruments used were Sekerka's Moral Courage Questionnaire and Ellison and Paloutzian's Spiritual Well-being Scale.
Results: A total of 186 nurses participated in the study, including 119 women and 67 men. The mean scores of moral courage indicated that the moral courage score was higher among women and those with higher educational qualifications. Also, age and existential health were important factors in predicting moral courage, while religious health had no significant effect.
Conclusions: The study's results showed that moral courage and spiritual health, especially in existential dimensions, play important roles in moral decision-making. Gender and age are also factors that can affect the level of moral courage.
