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The Effect of Prenatal Stress on Seizure Threshold and Histomorphometrical Changes on Cerebellar Cortex in NMRI Mice
Sahar Parsaee, Homa Mohseni Kochesfehani, Gholamreza Kaka, Homayon Sadraee, Mojtaba Kahali,
Volume 18, Issue 6 (9-2015)
Abstract

  Background: Stress is a mental or emotional disturbance that occurs in response to external stimuli and can also appear during pregnancy. The aim of this study is to investigate the effect of maternal stress during pregnancy on the cerebellar structure changes and seizure threshold of their offspring .

  Materials and Methods: In this experimental study, 20 pregnant female rats were divided into two groups: 1) Non stress group, and 2) Stress group which were under immobilization stress one hour for 14 days . The seizure threshold test in offspring was performed by injecting Pantilen tetrazol drug (PTZ)(n=8) . To investigate the cerebellum development, the offspring were divided into three groups . Control group: mothers did not any stress and offspring did not receive PTZ (n=4). Sham group: mothers did not stress but the offspring had received PTZ(n=4). Experimental group: mothers did stress and offispring did receive PTZ(n=4). After the section of cerebellum, the thickness of cerebellum layers and the number of cells in each layer were evaluated.

  Results: The mean of seizure threshold in the offspring whose mothers were under the stress of pregnancy significantly increased compared to children whose mothers no received stress (p<0.001). In the other side, mean number of purkinje cells in the experimental group significantly decreased compared with the other groups (p<0.001). No significant differences were found in the mean of granular and molecular layers thickness of cerebellum in the experimental group when compared with the other groups(p<0.05). However, mean cellular density in the granular layer of cerebellum in the experimental group significantly decreased compared to other groups (p<0.001).

Conclusion: Stress during pregnancy increased the seizure threshold in offspring and caused some developmental and structural disorders in the cerebellar rat offspring.


The Effectiveness of Emotion Regulation Skill Training Based on Dialectical Behavioral Therapy on Cognitive Emotion Regulation and Quality of Life of Patients With Cardiovascular Diseases
Seyed Vali Kazemi Rezaei, Keivan Kakabraee, Saeedeh Sadat Hosseini,
Volume 22, Issue 4 (9-2019)
Abstract
Background and Aim Psychological factors play a significant role in the exacerbation of cardiovascular diseases. This study aimed to investigate the effectiveness of teaching emotion regulation skill (based on dialectical behavioral therapy) on cognitive emotion regulation and Quality of Life (QoL) of patients with cardiovascular diseases.
Methods and Materials The present study has a quasi-experimental design with pretest-posttest and the control group. The statistical population of the study included all patients with cardiovascular diseases in Kermanshah City, Iran in 2018. Among them, 30 participants were selected by simple random sampling method. Then, they were randomly assigned to the two groups of experimental and control (each group 15 patients). We performed the intervention of excited ordering education based on dialectical behavioral therapy for the experimental group in eight 90-minute sessions, while the control group did not receive any intervention during this period. To collect study information, we used a short form of the emotional cognitive regulation questionnaire and MacNew Quality of Life Questionnaire. To analyze the data, we used the multivariate analysis of covariance in SPSS V. 20.
Ethical Considerations The Research Ethics Committee of Kermanshah University of Medical Sciences approved this study (Code: IR.KUMS.REC.1397.39).
Results The results showed that the scores of Positive Cognitive-Emotional Strategies and quality of life of cardiovascular patients after training of emotional regulation skills based on dialectical behavioral therapy in experimental group significantly increased in comparison with control group, and also Negative Strategies Scores were decreased (P<0.01). 
Conclusion Based on our positive study results, we recommend the therapists to use psychological treatments as complementary therapies for these patients.

Designing a Cognitive-Behavioral Coping Training Package with the Stress of Infertility and Its Effectiveness on Hope in Infertile Women
Samaneh Ghobadi, Mr Keivan Kakabraee, Mahmoud Goudarzi,
Volume 27, Issue 4 (10-2024)
Abstract
Introduction: For many people, infertility is a prominent crisis and cause of mental stress that causes many unfavorable psychological reactions. The purpose of the research is to design a cognitive-behavioral coping training package with the stress of infertility and its effectiveness on the hope of infertile women.
Methods: The present study was conducted using a mixed method using the qualitative part, content analysis type, and the quantitative part, semi-experimental, in the pre-test-post-test-two-month follow-up design with the control group. The statistical population of this research was infertile women referring to infertility centers and gynecology and infertility specialists in Kermanshah in 2022. A sample of forty women was selected as a sample using the purposeful sampling method and replaced in two groups (experimental and control) in a simple random manner. Data were collected from Newton et al.'s infertility stress questionnaire (1999) and Schneider's Hope (1991). The data was analyzed using a content validity test and repeated measurement variance analysis tests.
Results: The designed educational package was valid and adequate. The findings showed a significant difference between pre-test, post-test, and follow-up in the component of hope, and this difference continued until the follow-up stage.
Conclusions: The educational package on cognitive-behavioral coping with the stress of infertility of infertile women can be used to reduce the stress and increase the hope of infertile women.
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