Ehsanollah Ghaznavirad, Ali Fazeli, Rahmatollah Yazdani, Mohammad Rafii, Ali Jurabchi,
Volume 5, Issue 2 (Summer 2002)
Abstract
Introduction: Neisseria gonorrhoeae is a gram negative diplococci belong to family neisseriacae and is causative agent of gonorrheae. Culture and antibiograme of this bacteria is done lower than other cases and determination rate of MIC in this bacteria is inly done in reference laboratories. The goal of this study id introducing a relationship which in studied population, MIc more easily and eithout doing complex technical examinations is placed available for physicians.
Materials and Methods: In this research on 50 cases of Neisseria gonorrhoeae isolated from patients with gonorrhoeae antibiograme test were done and then for every antibiotic discs the zone of inhibition were measured. Then on the basis of instructions of NCCL for four antibiotics were planed to this disease (penicillin, tetracycline, spectinomycine and ceftriaxone) MIc on GC agar medium were measured and between zone of inhibition as an independent variable and MIC as a dependent variable linear regression is seen which from this line equation can understand how is the relation between MIc and zone of inhibition. It means that wether this relationship is direct or reverse?
Results: The findings show that in all antibiotics the relationship between zone of inhibition and MIc are negative (reverse) and regression coefient for first three antibiotics have (p<0.0001) and for fourth antibiotics has (p<0.001).
Conclusions: It means that with probability less than 0.0001 for penicillin, tetracycline, spectinomycine and probanility less than 0.001 for ceftriaxone can estimate the counter effect pf zone of inhibition and MIc in studied population.
