Showing 3 results for Javanmard
Marjan Hajimoradi Javarsiani, Javad Sajedianfard, Shagayegh Haghjooy Javanmard,
Volume 24, Issue 3 (August & September 2021)
Abstract
Background and Aim: Cancer cannot be explained only by genetic alterations but involves epigenetic processes. Modifying histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between Histone Deacetylases (HDAC) and Histone Acetyltransferases (HAT). The HDACs expression and activity could be involved in several tumorigenesis mechanisms, so their inhibition induces cancer cell cycle arrest and migration.
Methods & Materials: Quisinostat is a novel promising second-generation HDAC inhibitor class of hydroxamic acid with high cellular potency towards classes I and II HDACs. Therefore, its low IC50 (<0.5nM) and bioavailability have been chosen to carry out our studies. Cancer cells were treated with Quiznos at nM200, and cell migration was measured by fluorescent microscopy.
Ethical Considerations: This study was the result of a preliminary study of Shiraz University (Code: 96GCU3M1293).
Results: The data showed that treatment of cancer cells with Quiznos significantly (P<0.05) reduced cell migration. DMSO did not affect reducing cell migration.
Conclusion: In this project try to explore the possible therapeutic application of this HDAC inhibitor against colon cancer. This study showed Quisinostat exerts broad-spectrum antiproliferative activity and migration.
Mohammad Shamohammadi, Farzaneh Javanmard,
Volume 26, Issue 2 (June & July 2023)
Abstract
Introduction: Helicobacter pylori is the most common bacterial infection in the world. Infection with this bacterium occurs during the first 5 years of life. The present study was conducted with the aim of investigating the frequency of Helicobacter pylori infection in children and the types of histopathological changes related to it in endoscopic gastric biopsy samples of children.
Methods: In this cross-sectional-descriptive study, the prevalence of Helicobacter pylori and histopathological findings of 169 children with it were examined in the gastric endoscopic biopsy samples that were sent to the pathology department of Shahid Motahari Hospital in Urmia during March 2019 to March 2022. This study was approved by Research Ethics committee of Urmia University of Medical Science, Urmia, Iran (code: IR.UMSU.REC.1400.227).
Results: Out of 571 examined patients, 169 children (29.5%) were infected with Helicobacter pylori, the most common histopathological lesion was chronic gastritis. 40.3% of patients had active chronic inflammation as a result of gastric biopsy. No significant relationship was found between Helicobacter pylori and children's gender (P=0.29), but a significant relationship was observed between Helicobacter pylori results and children's age (P=0.04). A significant relationship was also observed between Helicobacter pylori infection and the severity of chronic gastritis (P=0.0001).
Conclusions: Considering that the inflammatory histopathological changes of the stomach are seen in all children with Helicobacter pylori infection and in more than 40% of cases this inflammation is of an active type, it is necessary to pay special attention to the early diagnosis and treatment of this infection in children.
Dr Jamileh Amirzadeh-Iranagh, Sima Ghorbanzadeh, Phd Student Yeganeh Dadashzadeh-Sangary, Phd Student Parsa Javanmard,
Volume 27, Issue 6 (1-2025)
Abstract
Introduction: The growing increase in the elderly population requires more research to identify the health priorities of this group, especially in critical situations such as the COVID-19 pandemic. Therefore, the current study was conducted to determine the influential components of marital satisfaction and its relationship with lifestyle in Urmia City in 2021.
Methods: In this descriptive-analytical and cross-sectional correlational study, 220 married elderly living in Urmia were selected through cluster sampling. The Miler's life satisfaction and Haynes's marital satisfaction questionnaires were used in addition to the demographic questionnaire to collect data in this research. Data were analyzed using descriptive statistical tests (mean and standard deviation, frequency, and percentage) and analytical (Pearson correlation coefficients and multiple linear regression) at a significant level of P ≤ 0.05.
Results: A step-by-step multiple linear regression model also revealed that variables of lifestyle (ß = -0.364), age (ß = 0.425), number of children (ß = 0.143), occupation (ß = 0.425) and illness (ß = 3.608) - had the most considerable contribution in the sensitive prediction of marital satisfaction. The regression model excluded other demographic variables.
Conclusions: This study showed that lifestyle and demographic variables such as age, number of children, occupation, and illness have the greatest contribution in predicting marital satisfaction. Therefore, it seems necessary to design counseling services in comprehensive health centers for this group so that counselors can teach healthy lifestyles to older adults to improve marital relationships.
