Journal of Arak University of Medical Sciences

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The Comparison of the Effects of Halothane and Lidocaine Infusion on Bispectral Index System (BIS)

Seyedeh Masomeh Hosseini Valami , Seyed Abbas Hosseini Jahromi , Asghar Jabbari, Amir Javadi , Toktam Karim Zadeh ,
Volume 16, Issue 4 (7-2013)

Abstract

Background: Familiarity with different methods and medications in anesthesia and producing sufficient depth of anesthesia are very important in anesthesia practice. Due to the central analgesic and sedative effect of lidocaine in the presence of the sufficient blood level, it can be used for general anesthesia. This study was carried out to compare the effect of halothane with lidocaine infusion on BIS during maintenance of anesthesia.

Materials and Methods: In this randomized double-blind controlled clinical trial, 66 patients scheduled for elective inguinal herniorrahaphy were randomized into two equal groups. For maintenance, one group received halothane (1%) with O2-N2O and another group received lidocaine infusion (100 &mug/kg/min). BIS was checked every 5 minutes for half an hour. Statistical analysis of data was done by Chi-square and T-test through SPSS software. P-values less than 0.05 were considered meaningful.

Results: Mean of BIS was 65.72 in the lidocaine group and 56.7 in the halothane group during the first 30 minutes. There was a significant statistical difference between the two groups (p<0.05).

Conclusion: Mean of BIS in lidocaine group was higher than that in the halothane group. If this indicates the presence of a light level of anesthesia, increasing the dose of hypnotics and opioids leads to an increase in the depth of anesthesia. However, since there is not any device for monitoring the effect of opioids on the central nervous system and the level of anesthesia, simultaneous monitoring of BIS and hemodynamic parameters seems to be a more reasonable idea.

Studying the Serum Factors Involved in the Metabolism of Vitamin D and Polymorphic Loci of VDR Gene on the Incidence of Parkinson's Disease in Isfahan Population

Rokhsareh Meamar, Maryam Ostadsharif, Ahmad Chitsaz, Mojgan Asadian Ghahfarokhi, Mehdi Kazemi, Seyed Morteza Javadirad,
Volume 20, Issue 4 (7-2017)

Abstract

Abstract

Background: Vitamin D was recognized with protective effects on nerve cells of Parkinson’s patients. The relationship between several VDR gene polymorphisms and age and risk of the disease was determined. Also, the relationship between VDR gene FOKI genotypes and PD was specified. The main goal of this study is to evaluate the relationship between polymorphic loci of FokI, TaqI, BsmI, ApaI and serum factor related to vitamin D metabolism in Isfahan population.

Materials and Methods: Case- control study of 125 Parkinson’s patients with their matched control individuals has been investigated based on Parkinson's disease brain bank criteria of Great Britain. After receiving consent, serum levels were measured. The genetic material was isolated by Miller protocol and polymorphisms has been analyzed and confirmed by repeated PCR-RFLP.

Results: Comparing the five serum factors between healthy subjects and patients with Parkinson's disease, we have shown a significant reduction in the levels of calcium, ALP and PTH (p<0.01). However, none of the levels of vitamin D and phosphate show any kind of significant relationship between patients and control subjects. Concentration of blood serumic factors including calcium and PTH showed p-values less than 0.01 between Parkinson's patients and control subjects according to different genotypes containing FokI-F allele,ApaI-A allele and BsmI-b allele .

Conclusion: The result of this study showed that each of FokI and ApaI recessive alleles can influence serum calcium and parathyroid hormone between healthy individuals and Parkinson's patients significantly.

Effect of Niacin on Side Effects of Bleomycin in Patients under Chemotherapy in Khansari Hospital of Arak

Zhila Mohseni, Iraj Javadi, Saeed Shanaghi,
Volume 21, Issue 4 (8-2018)

Abstract

Background and Aim: The history of using bleomycin in a hospital indicates a series of vast reactions in biological systems caused by direct and indirect effects. The biological responses of the biological system make this process more complicated. Increasing the prevalence and the incidence of cancerous diseases that are treated with bleomycin is of paramount importance. The aim of this study was to evaluate the effect of niacin on reducing the complications of bleomycin consumption in human model.
Materials and Methods: This experimental study was done as case-control and double-blind clinical trial. Of the cancer patients referred to Khansari hospital in Arak that underwent the bleomycin monotherapy, 20 subjects were randomly selected and divided into two groups. Each person in the first group (control) received 2 placebos per day (every 12 hours) and the second group (treatment) were given two pills of niacin (each pill: 100 mg) daily, and the results were recorded and analyzed.
Findings: A comparison between treatment and control groups showed a reduction in nausea and vomiting in the treatment group compared to the control group. The sense of taste disorder complication was reduced in the treatment group compared with the control group and this difference was statistically significant (p <0.05).
Conclusion: The results suggest that niacin can decrease the side effects of cancer treatment from different directions, including side effects, nausea, vomiting, loss of sense of taste, but its impact on respiratory problems probably because of the damage caused by bleomycin was not significant.

Coronavirus Pandemic a Factor in Delayed Mourning in Survivors: A Letter to The Editor

Seyed Mohammad Hossein Javadi, Maryam Sajadian,
Volume 23, Issue 1 (April & May 2020)

Abstract

This article has no abstract.

A Two-stage Approach Using Artificial Neural Networks for Diagnosis of Heart Diseases Based on ECG Data

Majid Mehrad, Majid Nojavan, Sedigh Raissi, Mehrdad Javadi,
Volume 25, Issue 2 (June & July 2022)

Abstract

Background and Aim Most heart diseases show symptoms on ECG, but diagnosing heart disease with ECG requires the knowledge and experience of medical specialized. Because these specialists may not always be available, it is necessary to design tools to diagnose heart disease in these situations. In this paper, a two-stage approach based on artificial neural networks is designed to diagnose heart disease using ECG information.In this study, we aim to propose a two-stage approach using artificial neural network (ANN) to diagnose heart disease based ECG data.
Methods & Materials To design the proposed approach, first the ECG data of 861 patients referred to medical centers in Arak, Iran were collected. The data were examined based on the opinions of specialists. Then, 154 features from ECG were used as inputs to the proposed model. In the first stage, an ANN was used to detect the ECG status (usable and unusable). In the second stage, using the usable ECG data, an ANN was used to diagnose the presence or absence of heart disease. Finally, the performance of the two-stage approach was evaluated and its accuracy and precision in determining the ECG quality and heart disease diagnosis were determined.
Ethical Considerations This study was approved by the ethics committee of Arak University of Medical Sciences (Code: IR.ARAKMU.REC.1400.138).
Results In the proposed approach, the ANN used for the determining the ECG status had a precision of 97.1% and an accuracy of 97.3%. The ANN used for the diagnosis of heart disease had a precision of 95.8% and an accuracy of 95.4%.
Conclusion Considering the high efficiency of the proposed approach in determining of ECG status and diagnosing heart disease, it is possible to use this approach to help the treatment staff.

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