Background: Use of inappropriate drugs in the elderly is a major health care concern. It is likely to increase adverse drug reactions and induce a substantial increase in health care costs. The aim of study was to evaluate inappropriate drug use in the elderly.

Materials and  Methods: In this cross-sectional study, collecting data were collected from patient’s file for 260 patients aged 60 years who were admitted to Rasoul-e-Akram Hospital in 2012. Potentially inappropriate medications were identified based on the 2012 Beers criteria.

Results: The mean age of the patients was 75±8.3 years. Overall, 58(22.3%) of the patients were treated with potentially inappropriate medications. The most common inappropriately prescribed medications were benzodiazepines, pethidine, and TCAs.

Conclusion: To improve prescription quality in elderly patients in Iran, preparing a scientific criterion or guideline is necessary.