Journal of Arak University of Medical Sciences

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Showing 2 results for Jamshidi Fard

Spreeding And Conduction Velocities of Primary Afferent Fibres Studies on Isolated (In Vitro) Mammalian Spinal Cord

Alireza Jamshidi Fard, J. Bagust ,
Volume 1, Issue 3 (Summer 1997)

Abstract

Wall and Shortland (1991) have shown that afferent fibres entering the cord in thoracic and lumbar roots of adult rats have branches that may penetrate up to 11 segments caudally from the root entry zone. We have investigated the extent of branching and conduction velocities of ascending and descending branches of lumbar and thoracic primary afferent in isolated spinal cords of adults hamsters (60-100g) and juvenile rats (30-46 g). Hemisected spinal cords were maintained at cold artificial cerebrospinal fluid (25-27 C) in which the Ca2+ had been replaced by Mn2+ (2mm) to block synaptic activity. Hamsters, antidromic conducted responses were obtained up to 10 segments caudal to dorsal roots T6-T7 and 17 segments rostral to L3. The mean conduction velocity was 3.7 m/s (s.e.m.& 0.4) for descending primary afferents(n=21) and 9.9 a 1.2 m/s for ascending afferents (n=26). In the rat , antidromic responses were measured over 4 segments caudal and 17 segments rostral to the L3 dorsal root. Conclusion velocities were 4.4 & 0.5 m/s and 7.7 & 0.7 m/s for descending and ascending branches respectively (n=4). The result were similar to those reported by Wall & Shortland , although the temperature. Difference between the in vitro and in vivo preparations would have resulted in approximately halving of the velocity in isolated cord preparation. The conduction velocity of descending fibres was about half fibres which may be related to size differences within the branches.

Effects of Melatonin on Visual Functioning of Patients with Multiple Sclerosis

Alireza Jamshidi Fard, Haleh Rafipour, Fardin Faraji,
Volume 16, Issue 5 (8-2013)

Abstract

Background: Several clinical studies suggest that melatonin is a neuroprotective molecule in neurodegenerative disorders and it showed to be reduced in Multiple Sclerosis (MS) patients. MS also results in blurred vision, papillitis and diplopia. The main objective of the study was to asses the influence of Melatonin supplimentation on visual characteristics in patients with MS.

Materials and Methods: In a Quasi Experimental plan, approved by AUMS ethical Committee, 34 (9 males and 25 females) patients with stable MS were asked to voluntearly participate in the study. All subjects (Mean EDSS 3.14) were taking their routine medications. Visual funtions were evaluated by Visual Functioning Questionnaire (VFO-25) and standard Pattern Reversal Visual Evoked Potentials (PR-VEP) records. Serum Melatonin levels were also measured using an ELISA assay. Recordings were performed after a single dose and after taking 1 tablet every night for 14 days, at the day 16th.

Results: In all subjects, Serum Melatonin levels were significantly enhanced. VFQ scores also showed significat improvement. Except the change in N75 latencies of left eyes, VEP latencies of P100, N145 of both eyes and N75 of right eyes were significantly (p<0.05) reduced.

Conclusion: Our findings suggest significat improvements of visual symptoms of MS after daily intake of 3 mg Melatonin. The results calls for further studies and clinical trails before asking all MS patients to take Melatonin suppliment every night.

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