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Abstract Background: Employed women like men, with their income have many physical and psychological problems and their mental health has been threaded. In our country the most rate of employed women are in Health and Education Ministries. So, we decided to determine the mental health of employed women in this both areas. Materials and Methods: This descriptive-analytic study was compared the mental health of 131 employed women in University of Medical Sciences with Education office in Arak city with General Health Questioner (GHQ) in 2008. Also effective factors on mental health based on age, education, income, number of children, mental and physical diseases history, marital status, habitancy condition, job satisfaction and experience were determined and data were analyzed by descriptive and analytical statistics. Results: There was difference between mental health level in women working in Medical Sciences University and Education office of Arak (p=0.041). Also income, age, mental disease history and job satisfaction had direct relationship with mental health Conclusion: Difference between psychological health level of women working in office of Medical Sciences University and Education were significant and income level, age, experience, mental disease history and job satisfaction are the most important factors for mental disorders.