Journal of Arak University of Medical Sciences

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Showing 2 results for Jafarzadeh

Corneal Thickness, Corneal Curvature and Refractive Errors of University Student in Arak

Afshin afshin Mohammadi, Ebrahim ebrahim Jafarzadehpur , Mohammad Rafiee,
Volume 16, Issue 8 (11-2013)

Abstract

Background: Racial and environmental factors may influence the refractive errors, corneal curvature and thickness. These variables were evaluated in Arak residential university students.

Materials and Methods: In this cross sectional observational study 400 students aged 18-30 years old living in Arak city that were eligible for the study. Demographic and past medical history information of all students was recorded and the corneal thickness (CT) and curvature (CC) and refractive error were measured. The correlation between refractive indices and CT and CC were investigated in all cases and also in refractive subgroups.

Results: The mean of CT, CC and power were 533.22(±32.02) µm, 7.75(±0.28) mm and 43±1.66 Diopters respectively. There were significant correlation between refractive error and CT in hyperopic subgroup (p=0.029) and between CT and CC in myopic subgroup (p=0.007). The mean of CC of myopic and astigmatic subgroups were significantly more than normal cases.

Conclusion: These findings are similar to the other international researches about corneal thickness, curvature and refractive errors in normal population. It seems further studies with more and older cases are necessary to investigate the impact of climatic condition and industrial air pollution on refractive errors and corneal parameters.

Antifungal Activity of Silver Nanoparticles, Copper Nanoparticles, Their Combination and with Amphotericin B against Candida glabrata In vitro and In vivo

Mahdi Jafarzadeh, Mojtaba Salouti, Rasoul Shokri,
Volume 20, Issue 6 (9-2017)

Abstract

Abstract
Background: Candida glabrata is the fourth most common cause of blood infection in America and, due to its resistance to amphotericin B, we have to look for new therapies. The aim of this study was to evaluate the antifungal properties of silver nanoparticles, copper and combine them together with amphotericin B in order to produce an effective drug.
Materials and Methods: Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for nano silver copper and combining them together and amphotericin B was conducted by macro dilution. By intraperitoneal injection, anti-fungal effect of nano silver, copper and combining them together and amphotericin B was evaluated in a mouse model.
Results: The amounts of MIC and MFC for silver nanoparticles, copper nanoparticles and their combination were 31 and 62.50 ppm, 31 and 62.50 ppm ,and 31and 15.50 ppm, respectively. The amounts of MIC and MFC for the combination of silver nanoparticles and amphotericin B were 8 and 15.5 ppm, also, 15.5 and 31 ppm for the combination of copper nanoparticles and amphotericin B. Mouse model study confirmed the effect of silver nanoparticles, copper nanoparticles and combining them together and amphotericin B against Candida glabrata. The combination of silver and copper nanoparticles had maximum effect and the combination of silver and copper nanoparticles with amphotericin B had minimum effect in animal model.
Conclusion: The combination of silver and copper nanoparticles has a better effect than other groups.

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